IDEAS home Printed from https://ideas.repec.org/a/eee/apmaco/v232y2014icp1000-1010.html
   My bibliography  Save this article

Mathematical modeling of p53 pulses in G2 phase with DNA damage

Author

Listed:
  • Zhang, L.W.
  • Cheng, Y.M.
  • Liew, K.M.

Abstract

A mathematical model of p53 pulses involved in G2/M phase transition is proposed to study the response of p53-centered signaling network and checkpoint mechanisms of G2 phase to DNA damages. The oscillation by p53-Mdm2 feedback loop as the response to DNA damage is first simulated. This follows by modeling the signaling network in G2 phase and realizing its importance in cell cycle progression. The signaling network is used to assess effects of different intensities of DNA damage on G2 phase transition. An examination of the dynamics of cell fate decision module shows that p53 arrester and Wip1 play key roles in DNA repair and may be an important target of cancer therapy. The present numerical analysis based on the proposed model may be useful for the inference of p53-mediated mechanisms in response to DNA damage in G2 phase under different damage conditions.

Suggested Citation

  • Zhang, L.W. & Cheng, Y.M. & Liew, K.M., 2014. "Mathematical modeling of p53 pulses in G2 phase with DNA damage," Applied Mathematics and Computation, Elsevier, vol. 232(C), pages 1000-1010.
    • Handle: RePEc:eee:apmaco:v:232:y:2014:i:c:p:1000-1010
    DOI: 10.1016/j.amc.2014.01.120
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0096300314001659
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.amc.2014.01.120?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Christopher J. Bakkenist & Michael B. Kastan, 2003. "DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation," Nature, Nature, vol. 421(6922), pages 499-506, January.
    2. Stephen P. Jackson & Jiri Bartek, 2009. "The DNA-damage response in human biology and disease," Nature, Nature, vol. 461(7267), pages 1071-1078, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Daipayan Banerjee & Kurt Langberg & Salar Abbas & Eric Odermatt & Praveen Yerramothu & Martin Volaric & Matthew A. Reidenbach & Kathy J. Krentz & C. Dustin Rubinstein & David L. Brautigan & Tarek Abba, 2021. "A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling," Nature Communications, Nature, vol. 12(1), pages 1-24, December.
    2. Ilaria Rosso & Corey Jones-Weinert & Francesca Rossiello & Matteo Cabrini & Silvia Brambillasca & Leonel Munoz-Sagredo & Zeno Lavagnino & Emanuele Martini & Enzo Tedone & Massimiliano Garre’ & Julio A, 2023. "Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Rut Molinuevo & Julien Menendez & Kora Cadle & Nabeela Ariqat & Marie Klaire Choy & Cayla Lagousis & Gwen Thomas & Catherine Strietzel & J. W. Bubolz & Lindsay Hinck, 2024. "Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Jérémy Sandoz & Max Cigrang & Amélie Zachayus & Philippe Catez & Lise-Marie Donnio & Clèmence Elly & Jadwiga Nieminuszczy & Pietro Berico & Cathy Braun & Sergey Alekseev & Jean-Marc Egly & Wojciech Ni, 2023. "Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Ross J. Hill & Nazareno Bona & Job Smink & Hannah K. Webb & Alastair Crisp & Juan I. Garaycoechea & Gerry P. Crossan, 2024. "p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Qin Qin & Jing Lu & Hongcheng Zhu & Liping Xu & Hongyan Cheng & Liangliang Zhan & Xi Yang & Chi Zhang & Xinchen Sun, 2014. "PARP-1 Val762Ala Polymorphism and Risk of Cancer: A Meta-Analysis Based on 39 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-12, May.
    7. Wen-Qi Ma & Xi-Qiong Han & Xin Wang & Ying Wang & Yi Zhu & Nai-Feng Liu, 2016. "Associations between XRCC1 Gene Polymorphisms and Coronary Artery Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-15, November.
    8. Pieranna Chiarella & Pasquale Capone & Renata Sisto, 2023. "Contribution of Genetic Polymorphisms in Human Health," IJERPH, MDPI, vol. 20(2), pages 1-15, January.
    9. Anne Margriet Heijink & Colin Stok & David Porubsky & Eleni Maria Manolika & Jurrian K. Kanter & Yannick P. Kok & Marieke Everts & H. Rudolf Boer & Anastasia Audrey & Femke J. Bakker & Elles Wierenga , 2022. "Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    10. Anthony Veltri & Christopher M. R. Lang & Gaia Cangiotti & Chim Kei Chan & Wen-Hui Lien, 2022. "ROR2 regulates self-renewal and maintenance of hair follicle stem cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    11. Lina Wang & Siru Li & Kai Wang & Na Wang & Qiaoling Liu & Zhen Sun & Li Wang & Lulu Wang & Quentin Liu & Chengli Song & Caigang Liu & Qingkai Yang, 2022. "DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    12. Alessio Magis & Michaela Limmer & Venkat Mudiyam & David Monchaud & Stefan Juranek & Katrin Paeschke, 2023. "UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    13. Feng Shi & Weigang Hu & Jiaojiao Wu & Miaofei Han & Jiazhou Wang & Wei Zhang & Qing Zhou & Jingjie Zhou & Ying Wei & Ying Shao & Yanbo Chen & Yue Yu & Xiaohuan Cao & Yiqiang Zhan & Xiang Sean Zhou & Y, 2022. "Deep learning empowered volume delineation of whole-body organs-at-risk for accelerated radiotherapy," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    14. Huimin Zhang & Yun Xiong & Dan Su & Chao Wang & Mrinal Srivastava & Mengfan Tang & Xu Feng & Min Huang & Zhen Chen & Junjie Chen, 2022. "TDP1-independent pathways in the process and repair of TOP1-induced DNA damage," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    15. Hanrui Zhang & Julian Kreis & Sven-Eric Schelhorn & Heike Dahmen & Thomas Grombacher & Michael Zühlsdorf & Frank T. Zenke & Yuanfang Guan, 2023. "Mapping combinatorial drug effects to DNA damage response kinase inhibitors," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    16. Sylvain V Costes & Artem Ponomarev & James L Chen & David Nguyen & Francis A Cucinotta & Mary Helen Barcellos-Hoff, 2007. "Image-Based Modeling Reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-Domains," PLOS Computational Biology, Public Library of Science, vol. 3(8), pages 1-12, August.
    17. Halh Al-Serori & Franziska Ferk & Michael Kundi & Andrea Bileck & Christopher Gerner & Miroslav Mišík & Armen Nersesyan & Monika Waldherr & Manuel Murbach & Tamara T Lah & Christel Herold-Mende & Andr, 2018. "Mobile phone specific electromagnetic fields induce transient DNA damage and nucleotide excision repair in serum-deprived human glioblastoma cells," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-17, April.
    18. Jenny Kaur Singh & Rebecca Smith & Magdalena B. Rother & Anton J. L. Groot & Wouter W. Wiegant & Kees Vreeken & Ostiane D’Augustin & Robbert Q. Kim & Haibin Qian & Przemek M. Krawczyk & Román González, 2021. "Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining," Nature Communications, Nature, vol. 12(1), pages 1-21, December.
    19. Miho M. Suzuki & Kenta Iijima & Koichi Ogami & Keiko Shinjo & Yoshiteru Murofushi & Jingqi Xie & Xuebing Wang & Yotaro Kitano & Akira Mamiya & Yuji Kibe & Tatsunori Nishimura & Fumiharu Ohka & Ryuta S, 2023. "TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    20. Ye Cai & Huifen Cao & Fang Wang & Yufei Zhang & Philipp Kapranov, 2022. "Complex genomic patterns of abasic sites in mammalian DNA revealed by a high-resolution SSiNGLe-AP method," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

    More about this item

    Keywords

    Mathematical modeling; p53; DNA damage; G2 phase; Checkpoints; Dynamics;
    All these keywords.

    JEL classification:

    • G2 - Financial Economics - - Financial Institutions and Services

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:apmaco:v:232:y:2014:i:c:p:1000-1010. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: https://www.journals.elsevier.com/applied-mathematics-and-computation .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.