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Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

Author

Listed:
  • Maksim V. Plikus

    (Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA)

  • Julie Ann Mayer

    (Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA)

  • Damon de la Cruz

    (Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA)

  • Ruth E. Baker

    (Centre for Mathematical Biology, Mathematical Institute, 24–29 St Giles’, Oxford, OX1 3LB UK)

  • Philip K. Maini

    (Centre for Mathematical Biology, Mathematical Institute, 24–29 St Giles’, Oxford, OX1 3LB UK
    Oxford Centre for Integrative Systems Biology, South Parks Road, Oxford OX1 3QU, UK)

  • Robert Maxson

    (Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA)

  • Cheng-Ming Chuong

    (Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA)

Abstract

Hair regeneration Fur-coated mammals could teach us important lessons about the control of stem cell replication: their skins contain thousands of hair follicles that cycle between growth and rest phases, and somehow all the individual follicle stem cells are programmed to coordinate cell divisions. Bone morphogenetic proteins (BMPs) and their inhibitors have now been identified as central to the control of waves of hair follicle activity. In mice regenerating hair after a close shave, variations in BMP2 and BMP4 production both regulate hair growth in individual follicles and coordinate it with nearby follicles. This pair of signalling molecules also fits the description of chalone, a hypothetical molecule introduced 50 years ago to explain patterned hair growth. This work has implications for carcinogenesis and stem-cell engineering studies, many of which assume that mouse skin stays homogeneous during lengthy experiments.

Suggested Citation

  • Maksim V. Plikus & Julie Ann Mayer & Damon de la Cruz & Ruth E. Baker & Philip K. Maini & Robert Maxson & Cheng-Ming Chuong, 2008. "Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration," Nature, Nature, vol. 451(7176), pages 340-344, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7176:d:10.1038_nature06457
    DOI: 10.1038/nature06457
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    Cited by:

    1. Hadas Sibony-Benyamini & Emil Aamar & David Enshell-Seijffers, 2023. "Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Anthony Veltri & Christopher M. R. Lang & Gaia Cangiotti & Chim Kei Chan & Wen-Hui Lien, 2022. "ROR2 regulates self-renewal and maintenance of hair follicle stem cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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