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Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy

Author

Listed:
  • Kielen R. Zuurbier

    (Department of Molecular Biology; University of Texas Southwestern Medical Center
    UT Southwestern Medical Center)

  • Rene Solano Fonseca

    (Department of Molecular Biology; University of Texas Southwestern Medical Center)

  • Sonja L. B. Arneaud

    (Department of Molecular Biology; University of Texas Southwestern Medical Center)

  • Jordan M. Wall

    (Department of Molecular Biology; University of Texas Southwestern Medical Center)

  • Juhee Kim

    (Department of Molecular Biology; University of Texas Southwestern Medical Center)

  • Lexus Tatge

    (Department of Molecular Biology; University of Texas Southwestern Medical Center)

  • Gupse Otuzoglu

    (Department of Molecular Biology; University of Texas Southwestern Medical Center)

  • Sofia Bali

    (UT Southwestern Medical Center
    UT Southwestern Medical Center)

  • Patrick Metang

    (Department of Molecular Biology; University of Texas Southwestern Medical Center)

  • Peter M. Douglas

    (Department of Molecular Biology; University of Texas Southwestern Medical Center
    UT Southwestern Medical Center
    Hamon Center for Regenerative Science and Medicine; UT Southwestern Medical Center)

Abstract

Neurons deploy diverse adaptive strategies to ensure survival and neurotransmission amid cellular stress. When these adaptive pathways are overwhelmed, functional impairment or neurodegeneration follows. Here we show that stressed neurons actively induce a state of transmissive dormancy as a protective measure. Extending observations of neurotrauma in C. elegans and mice, human dopaminergic neurons capable of surviving severe cellular challenges both decrease spontaneous activity and modulate dopamine homeostasis through the transcriptional regulator Yin Yang 1 (YY1). To bolster stress resilience and mitigate dopamine toxicity, YY1 increases expression of the vesicular monoamine transporter 2, vMAT2, while coordinately inhibiting dopamine synthesis through stabilization of a guanine quadruplex in intron 10 of tyrosine hydroxylase, TH. This dopaminergic stress response has the potential to cause circuit inactivation, yet safeguards neurons by minimizing the toxic accumulation of cytosolic dopamine and inducing a state of neuronal dormancy. In essence, neurons appear to actively prioritize viability over functionality.

Suggested Citation

  • Kielen R. Zuurbier & Rene Solano Fonseca & Sonja L. B. Arneaud & Jordan M. Wall & Juhee Kim & Lexus Tatge & Gupse Otuzoglu & Sofia Bali & Patrick Metang & Peter M. Douglas, 2024. "Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54958-9
    DOI: 10.1038/s41467-024-54958-9
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    1. Patricia González-Rodríguez & Enrico Zampese & Kristen A. Stout & Jaime N. Guzman & Ema Ilijic & Ben Yang & Tatiana Tkatch & Mihaela A. Stavarache & David L. Wokosin & Lin Gao & Michael G. Kaplitt & J, 2021. "Disruption of mitochondrial complex I induces progressive parkinsonism," Nature, Nature, vol. 599(7886), pages 650-656, November.
    2. Tao Lu & Liviu Aron & Joseph Zullo & Ying Pan & Haeyoung Kim & Yiwen Chen & Tun-Hsiang Yang & Hyun-Min Kim & Derek Drake & X. Shirley Liu & David A. Bennett & Monica P. Colaiácovo & Bruce A. Yankner, 2014. "REST and stress resistance in ageing and Alzheimer’s disease," Nature, Nature, vol. 507(7493), pages 448-454, March.
    3. Ravi S. Kamath & Andrew G. Fraser & Yan Dong & Gino Poulin & Richard Durbin & Monica Gotta & Alexander Kanapin & Nathalie Le Bot & Sergio Moreno & Marc Sohrmann & David P. Welchman & Peder Zipperlen &, 2003. "Systematic functional analysis of the Caenorhabditis elegans genome using RNAi," Nature, Nature, vol. 421(6920), pages 231-237, January.
    4. Guang-Hui Liu & Jing Qu & Keiichiro Suzuki & Emmanuel Nivet & Mo Li & Nuria Montserrat & Fei Yi & Xiuling Xu & Sergio Ruiz & Weiqi Zhang & Ulrich Wagner & Audrey Kim & Bing Ren & Ying Li & April Goebl, 2012. "Progressive degeneration of human neural stem cells caused by pathogenic LRRK2," Nature, Nature, vol. 491(7425), pages 603-607, November.
    5. Stephen P. Jackson & Jiri Bartek, 2009. "The DNA-damage response in human biology and disease," Nature, Nature, vol. 461(7267), pages 1071-1078, October.
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