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Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63

Author

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  • Songling Li

    (Fudan University
    Institute of Molecular Physiology, Shenzhen Bay Laboratory)

  • Bingxue Li

    (Fudan University
    Institute of Molecular Physiology, Shenzhen Bay Laboratory)

  • Li Gao

    (Fudan University)

  • Jingwen Wang

    (Fudan University)

  • Zhiqiang Yan

    (Fudan University
    Institute of Molecular Physiology, Shenzhen Bay Laboratory)

Abstract

Birds, reptiles and insects have the ability to discriminate humidity levels that influence their survival and geographic distribution. Insects are particularly susceptible to humidity changes due to high surface area to volume ratios, but it remains unclear how humidity sensors transduce humidity signals. Here we identified Or42b-expressing olfactory sensory neurons, which are required for moisture attraction in Drosophila. The sensilla housing Or42b neurons show cuticular deformations upon moist air stimuli, indicating a conversion of humidity into mechanical force. Accordingly, we found Or42b neurons directly respond to humidity changes and rely on the mechanosensitive ion channel TMEM63 to mediate humidity sensing (hygrosensation). Expressing human TMEM63B in Tmem63 mutant flies rescued their defective phenotype in moisture attraction, demonstrating functional conservation. Thus, our results reveal a role of Tmem63 in hygrosensation and support the strategy to detect humidity by transforming it into a mechanical stimulus, which is unique in sensory transduction.

Suggested Citation

  • Songling Li & Bingxue Li & Li Gao & Jingwen Wang & Zhiqiang Yan, 2022. "Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31253-z
    DOI: 10.1038/s41467-022-31253-z
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    References listed on IDEAS

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    1. Yuqi Qin & Daqi Yu & Dan Wu & Jiangqing Dong & William Thomas Li & Chang Ye & Kai Chit Cheung & Yingyi Zhang & Yun Xu & YongQiang Wang & Yun Stone Shi & Shangyu Dang, 2023. "Cryo-EM structure of TMEM63C suggests it functions as a monomer," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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