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Odorant reception in the malaria mosquito Anopheles gambiae

Author

Listed:
  • Allison F. Carey

    (Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA)

  • Guirong Wang

    (Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee 37235, USA)

  • Chih-Ying Su

    (Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA)

  • Laurence J. Zwiebel

    (Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee 37235, USA)

  • John R. Carlson

    (Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA)

Abstract

The mosquito Anopheles gambiae is the major vector of malaria in sub-Saharan Africa. It locates its human hosts primarily through olfaction, but little is known about the molecular basis of this process. Here we functionally characterize the Anopheles gambiae odorant receptor (AgOr) repertoire. We identify receptors that respond strongly to components of human odour and that may act in the process of human recognition. Some of these receptors are narrowly tuned, and some salient odorants elicit strong responses from only one or a few receptors, suggesting a central role for specific transmission channels in human host-seeking behaviour. This analysis of the Anopheles gambiae receptors permits a comparison with the corresponding Drosophila melanogaster odorant receptor repertoire. We find that odorants are differentially encoded by the two species in ways consistent with their ecological needs. Our analysis of the Anopheles gambiae repertoire identifies receptors that may be useful targets for controlling the transmission of malaria.

Suggested Citation

  • Allison F. Carey & Guirong Wang & Chih-Ying Su & Laurence J. Zwiebel & John R. Carlson, 2010. "Odorant reception in the malaria mosquito Anopheles gambiae," Nature, Nature, vol. 464(7285), pages 66-71, March.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7285:d:10.1038_nature08834
    DOI: 10.1038/nature08834
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    Cited by:

    1. Edmund J. Norris & Joel R. Coats, 2017. "Current and Future Repellent Technologies: The Potential of Spatial Repellents and Their Place in Mosquito-Borne Disease Control," IJERPH, MDPI, vol. 14(2), pages 1-15, January.
    2. Pranjul Singh & Shefali Goyal & Smith Gupta & Sanket Garg & Abhinav Tiwari & Varad Rajput & Alexander Shakeel Bates & Arjit Kant Gupta & Nitin Gupta, 2023. "Combinatorial encoding of odors in the mosquito antennal lobe," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Songling Li & Bingxue Li & Li Gao & Jingwen Wang & Zhiqiang Yan, 2022. "Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Xiao Xu & Long Zhang & Xingbo Zhao, 2023. "The Aversive Response of the Locust Locusta migratoria to 3-Octanone, an Odorant from Fungal Pathogens, Is Mediated by a Chemosensory Protein," Agriculture, MDPI, vol. 13(8), pages 1-13, August.

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