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Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation

Author

Listed:
  • Zhiqiang Yan

    (Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

  • Wei Zhang

    (Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

  • Ye He

    (Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

  • David Gorczyca

    (Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

  • Yang Xiang

    (Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

  • Li E. Cheng

    (Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

  • Shan Meltzer

    (Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

  • Lily Yeh Jan

    (Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

  • Yuh Nung Jan

    (Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA)

Abstract

Mechanotransduction channels studied to date are mainly involved with sensing noxious mechanical stimuli; here NOMPC, a member of the TRP ion channel family, is identified as a pore-forming subunit of an ion channel essential to the sensation of gentle touch in Drosophila.

Suggested Citation

  • Zhiqiang Yan & Wei Zhang & Ye He & David Gorczyca & Yang Xiang & Li E. Cheng & Shan Meltzer & Lily Yeh Jan & Yuh Nung Jan, 2013. "Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation," Nature, Nature, vol. 493(7431), pages 221-225, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7431:d:10.1038_nature11685
    DOI: 10.1038/nature11685
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    Cited by:

    1. Yuqi Qin & Daqi Yu & Dan Wu & Jiangqing Dong & William Thomas Li & Chang Ye & Kai Chit Cheung & Yingyi Zhang & Yun Xu & YongQiang Wang & Yun Stone Shi & Shangyu Dang, 2023. "Cryo-EM structure of TMEM63C suggests it functions as a monomer," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Songling Li & Bingxue Li & Li Gao & Jingwen Wang & Zhiqiang Yan, 2022. "Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Zhengyang Kong & Elvis K. Boahen & Dong Jun Kim & Fenglong Li & Joo Sung Kim & Hyukmin Kweon & So Young Kim & Hanbin Choi & Jin Zhu & Wu Ying & Do Hwan Kim, 2024. "Ultrafast underwater self-healing piezo-ionic elastomer via dynamic hydrophobic-hydrolytic domains," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    5. Shannon Trombley & Jackson Powell & Pavithran Guttipatti & Andrew Matamoros & Xiaohui Lin & Tristan O’Harrow & Tobias Steinschaden & Leann Miles & Qin Wang & Shuchao Wang & Jingyun Qiu & Qingyang Li &, 2023. "Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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