IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-31040-w.html
   My bibliography  Save this article

Hippocampal representations switch from errors to predictions during acquisition of predictive associations

Author

Listed:
  • Fraser Aitken

    (University College London
    King’s College London, St Thomas’ Hospital)

  • Peter Kok

    (University College London)

Abstract

We constantly exploit the statistical regularities in our environment to help guide our perception. The hippocampus has been suggested to play a pivotal role in both learning environmental statistics, as well as exploiting them to generate perceptual predictions. However, it is unclear how the hippocampus balances encoding new predictive associations with the retrieval of existing ones. Here, we present the results of two high resolution human fMRI studies (N = 24 for both experiments) directly investigating this. Participants were exposed to auditory cues that predicted the identity of an upcoming visual shape (with 75% validity). Using multivoxel decoding analysis, we find that the hippocampus initially preferentially represents unexpected shapes (i.e., those that violate the cue regularities), but later switches to representing the cue-predicted shape regardless of which was actually presented. These findings demonstrate that the hippocampus is involved both acquiring and exploiting predictive associations, and is dominated by either errors or predictions depending on whether learning is ongoing or complete.

Suggested Citation

  • Fraser Aitken & Peter Kok, 2022. "Hippocampal representations switch from errors to predictions during acquisition of predictive associations," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31040-w
    DOI: 10.1038/s41467-022-31040-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-31040-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-31040-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Anne Maass & Hartmut Schütze & Oliver Speck & Andrew Yonelinas & Claus Tempelmann & Hans-Jochen Heinze & David Berron & Arturo Cardenas-Blanco & Kay H. Brodersen & Klaas Enno Stephan & Emrah Düzel, 2014. "Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    2. Aidan J. Horner & James A. Bisby & Daniel Bush & Wen-Jing Lin & Neil Burgess, 2015. "Evidence for holistic episodic recollection via hippocampal pattern completion," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    3. Bernhard P. Staresina & Thomas P. Reber & Johannes Niediek & Jan Boström & Christian E. Elger & Florian Mormann, 2019. "Recollection in the human hippocampal-entorhinal cell circuitry," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    4. R. A. Poldrack & J. Clark & E. J. Paré-Blagoev & D. Shohamy & J. Creso Moyano & C. Myers & M. A. Gluck, 2001. "Interactive memory systems in the human brain," Nature, Nature, vol. 414(6863), pages 546-550, November.
    5. Oded Bein & Katherine Duncan & Lila Davachi, 2020. "Mnemonic prediction errors bias hippocampal states," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    6. Nicholas C. Hindy & Emily W. Avery & Nicholas B. Turk-Browne, 2019. "Hippocampal-neocortical interactions sharpen over time for predictive actions," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    7. Oded Bein & Katherine Duncan & Lila Davachi, 2020. "Publisher Correction: Mnemonic prediction errors bias hippocampal states," Nature Communications, Nature, vol. 11(1), pages 1-1, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Annika Garlichs & Helen Blank, 2024. "Prediction error processing and sharpening of expected information across the face-processing hierarchy," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. James W. Antony & Jacob Dam & Jarett R. Massey & Alexander J. Barnett & Kelly A. Bennion, 2023. "Long-term, multi-event surprise correlates with enhanced autobiographical memory," Nature Human Behaviour, Nature, vol. 7(12), pages 2152-2168, December.
    2. Marcel Bausch & Johannes Niediek & Thomas P. Reber & Sina Mackay & Jan Boström & Christian E. Elger & Florian Mormann, 2021. "Concept neurons in the human medial temporal lobe flexibly represent abstract relations between concepts," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Zhongyu Hu & Wenxi Zhou & Jiongjiong Yang, 2021. "The effect of encoding task on the forgetting of object gist and details," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-26, September.
    4. Li Zheng & Zhiyao Gao & Andrew S. McAvan & Eve A. Isham & Arne D. Ekstrom, 2021. "Partially overlapping spatial environments trigger reinstatement in hippocampus and schema representations in prefrontal cortex," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    5. Sanne Ten Oever & Alexander T. Sack & Carina R. Oehrn & Nikolai Axmacher, 2021. "An engram of intentionally forgotten information," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    6. Baer, Naomi & Barry, Erica & Smith, Gary, 2020. "The name game: The importance of resourcefulness, ruses, and recall in stock ticker symbols," The Quarterly Review of Economics and Finance, Elsevier, vol. 76(C), pages 410-413.
    7. Xiaxia Xu & Lingzhen Song & Rebecca Kringel & Ileana L. Hanganu-Opatz, 2021. "Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    8. Peter Smittenaar & George Prichard & Thomas H B FitzGerald & Joern Diedrichsen & Raymond J Dolan, 2014. "Transcranial Direct Current Stimulation of Right Dorsolateral Prefrontal Cortex Does Not Affect Model-Based or Model-Free Reinforcement Learning in Humans," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-8, January.
    9. Sina Mackay & Thomas P. Reber & Marcel Bausch & Jan Boström & Christian E. Elger & Florian Mormann, 2024. "Concept and location neurons in the human brain provide the ‘what’ and ‘where’ in memory formation," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    10. Raphael Koster & Tricia X Seow & Raymond J Dolan & Emrah Düzel, 2016. "Stimulus Novelty Energizes Actions in the Absence of Explicit Reward," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-10, July.
    11. Sang Wan Lee & John P O’Doherty & Shinsuke Shimojo, 2015. "Neural Computations Mediating One-Shot Learning in the Human Brain," PLOS Biology, Public Library of Science, vol. 13(4), pages 1-36, April.
    12. Nisha Puthiyedth & Carlos Riveros & Regina Berretta & Pablo Moscato, 2016. "Identification of Differentially Expressed Genes through Integrated Study of Alzheimer’s Disease Affected Brain Regions," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-29, April.
    13. Geoffrey Hodgson, 2010. "Choice, habit and evolution," Journal of Evolutionary Economics, Springer, vol. 20(1), pages 1-18, January.
    14. Gabriel B. Benigno & Roberto C. Budzinski & Zachary W. Davis & John H. Reynolds & Lyle Muller, 2023. "Waves traveling over a map of visual space can ignite short-term predictions of sensory input," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31040-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.