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Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding

Author

Listed:
  • Anne Maass

    (Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg)

  • Hartmut Schütze

    (Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg)

  • Oliver Speck

    (Biomedical Magnetic Resonance, Institute of Experimental Physics, Otto-von-Guericke-University Magdeburg
    German Center for Neurodegenerative Diseases (DZNE), Site Magdeburg
    Leibniz Institute for Neurobiology
    Center for Behavioral and Brain Sciences, CBBS)

  • Andrew Yonelinas

    (Center for Mind and Brain, University of California)

  • Claus Tempelmann

    (Otto-von-Guericke-University Magdeburg)

  • Hans-Jochen Heinze

    (German Center for Neurodegenerative Diseases (DZNE), Site Magdeburg
    Leibniz Institute for Neurobiology
    Center for Behavioral and Brain Sciences, CBBS
    Otto-von-Guericke-University Magdeburg)

  • David Berron

    (Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg)

  • Arturo Cardenas-Blanco

    (German Center for Neurodegenerative Diseases (DZNE), Site Magdeburg)

  • Kay H. Brodersen

    (Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich & ETH Zurich)

  • Klaas Enno Stephan

    (Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich & ETH Zurich
    Wellcome Trust Centre for Neuroimaging, University College London)

  • Emrah Düzel

    (Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg
    German Center for Neurodegenerative Diseases (DZNE), Site Magdeburg
    Center for Behavioral and Brain Sciences, CBBS
    Otto-von-Guericke-University Magdeburg)

Abstract

The ability to form long-term memories for novel events depends on information processing within the hippocampus (HC) and entorhinal cortex (EC). The HC–EC circuitry shows a quantitative segregation of anatomical directionality into different neuronal layers. Whereas superficial EC layers mainly project to dentate gyrus (DG), CA3 and apical CA1 layers, HC output is primarily sent from pyramidal CA1 layers and subiculum to deep EC layers. Here we utilize this directionality information by measuring encoding activity within HC/EC subregions with 7 T high resolution functional magnetic resonance imaging (fMRI). Multivariate Bayes decoding within HC/EC subregions shows that processing of novel information most strongly engages the input structures (superficial EC and DG/CA2–3), whereas subsequent memory is more dependent on activation of output regions (deep EC and pyramidal CA1). This suggests that while novelty processing is strongly related to HC–EC input pathways, the memory fate of a novel stimulus depends more on HC–EC output.

Suggested Citation

  • Anne Maass & Hartmut Schütze & Oliver Speck & Andrew Yonelinas & Claus Tempelmann & Hans-Jochen Heinze & David Berron & Arturo Cardenas-Blanco & Kay H. Brodersen & Klaas Enno Stephan & Emrah Düzel, 2014. "Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6547
    DOI: 10.1038/ncomms6547
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    Cited by:

    1. Raphael Koster & Tricia X Seow & Raymond J Dolan & Emrah Düzel, 2016. "Stimulus Novelty Energizes Actions in the Absence of Explicit Reward," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-10, July.
    2. Nisha Puthiyedth & Carlos Riveros & Regina Berretta & Pablo Moscato, 2016. "Identification of Differentially Expressed Genes through Integrated Study of Alzheimer’s Disease Affected Brain Regions," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-29, April.
    3. Fraser Aitken & Peter Kok, 2022. "Hippocampal representations switch from errors to predictions during acquisition of predictive associations," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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