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Evidence for holistic episodic recollection via hippocampal pattern completion

Author

Listed:
  • Aidan J. Horner

    (UCL Institute of Cognitive Neuroscience
    UCL Institute of Neurology)

  • James A. Bisby

    (UCL Institute of Cognitive Neuroscience
    UCL Institute of Neurology)

  • Daniel Bush

    (UCL Institute of Cognitive Neuroscience
    UCL Institute of Neurology)

  • Wen-Jing Lin

    (UCL Institute of Cognitive Neuroscience
    UCL Institute of Neurology)

  • Neil Burgess

    (UCL Institute of Cognitive Neuroscience
    UCL Institute of Neurology)

Abstract

Recollection is thought to be the hallmark of episodic memory. Here we provide evidence that the hippocampus binds together the diverse elements forming an event, allowing holistic recollection via pattern completion of all elements. Participants learn complex ‘events’ from multiple overlapping pairs of elements, and are tested on all pairwise associations. At encoding, element ‘types’ (locations, people and objects/animals) produce activation in distinct neocortical regions, while hippocampal activity predicts memory performance for all within-event pairs. When retrieving a pairwise association, neocortical activity corresponding to all event elements is reinstated, including those incidental to the task. Participant’s degree of incidental reinstatement correlates with their hippocampal activity. Our results suggest that event elements, represented in distinct neocortical regions, are bound into coherent ‘event engrams’ in the hippocampus that enable episodic recollection—the re-experiencing or holistic retrieval of all aspects of an event—via a process of hippocampal pattern completion and neocortical reinstatement.

Suggested Citation

  • Aidan J. Horner & James A. Bisby & Daniel Bush & Wen-Jing Lin & Neil Burgess, 2015. "Evidence for holistic episodic recollection via hippocampal pattern completion," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8462
    DOI: 10.1038/ncomms8462
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    Cited by:

    1. Baer, Naomi & Barry, Erica & Smith, Gary, 2020. "The name game: The importance of resourcefulness, ruses, and recall in stock ticker symbols," The Quarterly Review of Economics and Finance, Elsevier, vol. 76(C), pages 410-413.
    2. Zhongyu Hu & Wenxi Zhou & Jiongjiong Yang, 2021. "The effect of encoding task on the forgetting of object gist and details," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-26, September.
    3. Li Zheng & Zhiyao Gao & Andrew S. McAvan & Eve A. Isham & Arne D. Ekstrom, 2021. "Partially overlapping spatial environments trigger reinstatement in hippocampus and schema representations in prefrontal cortex," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Fraser Aitken & Peter Kok, 2022. "Hippocampal representations switch from errors to predictions during acquisition of predictive associations," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Gabriel B. Benigno & Roberto C. Budzinski & Zachary W. Davis & John H. Reynolds & Lyle Muller, 2023. "Waves traveling over a map of visual space can ignite short-term predictions of sensory input," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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