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Recovery of neural dynamics criticality in personalized whole-brain models of stroke

Author

Listed:
  • Rodrigo P. Rocha

    (Universidade Federal de Santa Catarina
    University of São Paulo
    Università di Padova)

  • Loren Koçillari

    (Università di Padova
    Istituto Italiano di Tecnologia
    Università di Padova and INFN)

  • Samir Suweis

    (Università di Padova
    Università di Padova and INFN)

  • Michele Filippo De Grazia

    (IRCCS San Camillo Hospital)

  • Michel Thiebaut Schotten

    (Sorbonne Universities
    CEA University of Bordeaux)

  • Marco Zorzi

    (IRCCS San Camillo Hospital
    Università di Padova)

  • Maurizio Corbetta

    (Università di Padova
    Università di Padova
    Fondazione Biomedica)

Abstract

The critical brain hypothesis states that biological neuronal networks, because of their structural and functional architecture, work near phase transitions for optimal response to internal and external inputs. Criticality thus provides optimal function and behavioral capabilities. We test this hypothesis by examining the influence of brain injury (strokes) on the criticality of neural dynamics estimated at the level of single participants using directly measured individual structural connectomes and whole-brain models. Lesions engender a sub-critical state that recovers over time in parallel with behavior. The improvement of criticality is associated with the re-modeling of specific white-matter connections. We show that personalized whole-brain dynamical models poised at criticality track neural dynamics, alteration post-stroke, and behavior at the level of single participants.

Suggested Citation

  • Rodrigo P. Rocha & Loren Koçillari & Samir Suweis & Michele Filippo De Grazia & Michel Thiebaut Schotten & Marco Zorzi & Maurizio Corbetta, 2022. "Recovery of neural dynamics criticality in personalized whole-brain models of stroke," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30892-6
    DOI: 10.1038/s41467-022-30892-6
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    References listed on IDEAS

    as
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    Cited by:

    1. Valentina Pacella & Victor Nozais & Lia Talozzi & Majd Abdallah & Demian Wassermann & Stephanie J. Forkel & Michel Thiebaut de Schotten, 2024. "The morphospace of the brain-cognition organisation," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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