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Behavioural clusters and predictors of performance during recovery from stroke

Author

Listed:
  • L. E. Ramsey

    (Carroll University)

  • J. S. Siegel

    (Washington University School of Medicine)

  • C. E. Lang

    (Washington University School of Medicine
    Program in Physical Therapy, Washington University School of Medicine
    Program in Occupational Therapy, Washington University School of Medicine)

  • M. Strube

    (Washington University)

  • G. L. Shulman

    (Washington University School of Medicine)

  • M. Corbetta

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    Washington University)

Abstract

We examined the patterns and variability of post-stroke recovery in multiple behavioural domains. A large cohort of first-time stroke patients with heterogeneous lesions was studied prospectively and longitudinally at one to two weeks, three months and one year after the stroke using structural magnetic resonance imaging to measure lesion anatomy and 44 neuropsychological tests to assess behavioural outcomes. Impairment was described at all time points by a few clusters of correlated deficits. The time course and magnitude of recovery was similar across behavioural domains, with change scores largely proportional to the initial deficit and most recovery occurring within the first three months. Damage to specific white matter tracts produced poorer recovery for several domains: attention (superior longitudinal fasciculus II/III), language (posterior arcuate fasciculus) and motor (corticospinal tract). Finally, after accounting for the severity of the initial deficit, language and visual memory recovery was worse for those with lower levels of education, while the occurrence of multiple deficits negatively impacted attention recovery.

Suggested Citation

  • L. E. Ramsey & J. S. Siegel & C. E. Lang & M. Strube & G. L. Shulman & M. Corbetta, 2017. "Behavioural clusters and predictors of performance during recovery from stroke," Nature Human Behaviour, Nature, vol. 1(3), pages 1-10, March.
    • Handle: RePEc:nat:nathum:v:1:y:2017:i:3:d:10.1038_s41562-016-0038
    DOI: 10.1038/s41562-016-0038
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    Cited by:

    1. Rodrigo P. Rocha & Loren Koçillari & Samir Suweis & Michele Filippo De Grazia & Michel Thiebaut Schotten & Marco Zorzi & Maurizio Corbetta, 2022. "Recovery of neural dynamics criticality in personalized whole-brain models of stroke," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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