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Brain disconnections link structural connectivity with function and behaviour

Author

Listed:
  • Michel Thiebaut de Schotten

    (Sorbonne University
    University of Bordeaux)

  • Chris Foulon

    (UCL)

  • Parashkev Nachev

    (UCL)

Abstract

Brain lesions do not just disable but also disconnect brain areas, which once deprived of their input or output, can no longer subserve behaviour and cognition. The role of white matter connections has remained an open question for the past 250 years. Based on 1333 stroke lesions, here we reveal the human Disconnectome and demonstrate its relationship to the functional segregation of the human brain. Results indicate that functional territories are not only defined by white matter connections, but also by the highly stereotyped spatial distribution of brain disconnections. While the former has granted us the possibility to map 590 functions on the white matter of the whole brain, the latter compels a revision of the taxonomy of brain functions. Overall, our freely available Atlas of White Matter Function will enable improved clinical-neuroanatomical predictions for brain lesion studies and provide a platform for explorations in the domain of cognition.

Suggested Citation

  • Michel Thiebaut de Schotten & Chris Foulon & Parashkev Nachev, 2020. "Brain disconnections link structural connectivity with function and behaviour," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18920-9
    DOI: 10.1038/s41467-020-18920-9
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    Cited by:

    1. Rodrigo P. Rocha & Loren Koçillari & Samir Suweis & Michele Filippo De Grazia & Michel Thiebaut Schotten & Marco Zorzi & Maurizio Corbetta, 2022. "Recovery of neural dynamics criticality in personalized whole-brain models of stroke," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Fang-Cheng Yeh, 2022. "Population-based tract-to-region connectome of the human brain and its hierarchical topology," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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