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Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions

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  • Xiaowei Xu

    (Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center)

  • Shoufu Duan

    (Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center)

  • Xu Hua

    (Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center)

  • Zhiming Li

    (Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center)

  • Richard He

    (Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center)

  • Zhiguo Zhang

    (Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center)

Abstract

Newly synthesized H3.1 and H3.3 histones are assembled into nucleosomes by different histone chaperones in replication-coupled and replication-independent pathways, respectively. However, it is not clear how parental H3.3 molecules are transferred following DNA replication, especially when compared to H3.1. Here, by monitoring parental H3.1- and H3.3-SNAP signals, we show that parental H3.3, like H3.1, are stably transferred into daughter cells. Moreover, Mcm2-Pola1 and Pole3-Pole4, two pathways involved in parental histone transfer based upon the analysis of modifications on parental histones, participate in the transfer of both H3.1 and H3.3 following DNA replication. Lastly, we found that Mcm2, Pole3 and Pole4 mutants defective in parental histone transfer show defects in chromosome segregation. These results indicate that in contrast to deposition of newly synthesized H3.1 and H3.3, transfer of parental H3.1 and H3.3 is mediated by these shared mechanisms, which contributes to epigenetic memory of gene expression and maintenance of genome stability.

Suggested Citation

  • Xiaowei Xu & Shoufu Duan & Xu Hua & Zhiming Li & Richard He & Zhiguo Zhang, 2022. "Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30298-4
    DOI: 10.1038/s41467-022-30298-4
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    References listed on IDEAS

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    1. Simon J. Elsässer & Kyung-Min Noh & Nichole Diaz & C. David Allis & Laura A. Banaszynski, 2015. "Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells," Nature, Nature, vol. 522(7555), pages 240-244, June.
    2. Karolin Luger & Armin W. Mäder & Robin K. Richmond & David F. Sargent & Timothy J. Richmond, 1997. "Crystal structure of the nucleosome core particle at 2.8 Å resolution," Nature, Nature, vol. 389(6648), pages 251-260, September.
    3. Camille Clément & Guillermo A. Orsi & Alberto Gatto & Ekaterina Boyarchuk & Audrey Forest & Bassam Hajj & Judith Miné-Hattab & Mickaël Garnier & Zachary A. Gurard-Levin & Jean-Pierre Quivy & Geneviève, 2018. "High-resolution visualization of H3 variants during replication reveals their controlled recycling," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
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    1. Congcong Tian & Jiaqi Zhou & Xinran Li & Yuan Gao & Qing Wen & Xing Kang & Nan Wang & Yuan Yao & Jiuhang Jiang & Guibing Song & Tianjun Zhang & Suili Hu & JingYi Liao & Chuanhe Yu & Zhiquan Wang & Xia, 2023. "Impaired histone inheritance promotes tumor progression," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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