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Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits

Author

Listed:
  • Spencer Ward

    (University of California, San Diego)

  • Conor Riley

    (University of California, San Diego)

  • Erin M. Carey

    (Salk Institute for Biological Studies)

  • Jenny Nguyen

    (University of California, San Diego)

  • Sadik Esener

    (University of California, San Diego
    University of California, San Diego)

  • Axel Nimmerjahn

    (Salk Institute for Biological Studies)

  • Donald J. Sirbuly

    (University of California, San Diego
    University of California, San Diego)

Abstract

Central to advancing our understanding of neural circuits is developing minimally invasive, multi-modal interfaces capable of simultaneously recording and modulating neural activity. Recent devices have focused on matching the mechanical compliance of tissue to reduce inflammatory responses. However, reductions in the size of multi-modal interfaces are needed to further improve biocompatibility and long-term recording capabilities. Here a multi-modal coaxial microprobe design with a minimally invasive footprint (8–14 µm diameter over millimeter lengths) that enables efficient electrical and optical interrogation of neural networks is presented. In the brain, the probes allowed robust electrical measurement and optogenetic stimulation. Scalable fabrication strategies can be used with various electrical and optical materials, making the probes highly customizable to experimental requirements, including length, diameter, and mechanical properties. Given their negligible inflammatory response, these probes promise to enable a new generation of readily tunable multi-modal devices for long-term, minimally invasive interfacing with neural circuits.

Suggested Citation

  • Spencer Ward & Conor Riley & Erin M. Carey & Jenny Nguyen & Sadik Esener & Axel Nimmerjahn & Donald J. Sirbuly, 2022. "Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30275-x
    DOI: 10.1038/s41467-022-30275-x
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    References listed on IDEAS

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    1. James J. Jun & Nicholas A. Steinmetz & Joshua H. Siegle & Daniel J. Denman & Marius Bauza & Brian Barbarits & Albert K. Lee & Costas A. Anastassiou & Alexandru Andrei & Çağatay Aydın & Mladen Barbic &, 2017. "Fully integrated silicon probes for high-density recording of neural activity," Nature, Nature, vol. 551(7679), pages 232-236, November.
    2. Kohei J. Sekiguchi & Pavel Shekhtmeyster & Katharina Merten & Alexander Arena & Daniela Cook & Elizabeth Hoffman & Alexander Ngo & Axel Nimmerjahn, 2016. "Imaging large-scale cellular activity in spinal cord of freely behaving mice," Nature Communications, Nature, vol. 7(1), pages 1-13, September.
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