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De novo inter-regional coactivations of preconfigured local ensembles support memory

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  • Hiroyuki Miyawaki

    (Osaka City University Graduate School of Medicine)

  • Kenji Mizuseki

    (Osaka City University Graduate School of Medicine)

Abstract

Neuronal ensembles in the amygdala, ventral hippocampus, and prefrontal cortex are involved in fear memory; however, how inter-regional ensemble interactions support memory remains elusive. Using multi-regional large-scale electrophysiology in the aforementioned structures of fear-conditioned rats, we found that the local ensembles activated during fear memory acquisition are inter-regionally coactivated during the subsequent sleep period, which relied on brief bouts of fast network oscillations. During memory retrieval, the coactivations reappeared, together with fast oscillations. Coactivation-participating-ensembles were configured prior to memory acquisition in the amygdala and prefrontal cortex but developed through experience in the hippocampus. Our findings suggest that elements of a given memory are instantly encoded within various brain regions in a preconfigured manner, whereas hippocampal ensembles and the network for inter-regional integration of the distributed information develop in an experience-dependent manner to form a new memory, which is consistent with the hippocampal memory index hypothesis.

Suggested Citation

  • Hiroyuki Miyawaki & Kenji Mizuseki, 2022. "De novo inter-regional coactivations of preconfigured local ensembles support memory," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28929-x
    DOI: 10.1038/s41467-022-28929-x
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    References listed on IDEAS

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    1. George Dragoi & Susumu Tonegawa, 2011. "Preplay of future place cell sequences by hippocampal cellular assemblies," Nature, Nature, vol. 469(7330), pages 397-401, January.
    2. Fabricio H. Do-Monte & Kelvin Quiñones-Laracuente & Gregory J. Quirk, 2015. "A temporal shift in the circuits mediating retrieval of fear memory," Nature, Nature, vol. 519(7544), pages 460-463, March.
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    Cited by:

    1. Jun Liu & Arron F. Hall & Dong V. Wang, 2024. "Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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