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A temporal shift in the circuits mediating retrieval of fear memory

Author

Listed:
  • Fabricio H. Do-Monte

    (University of Puerto Rico School of Medicine, PO Box 365067, San Juan 00936, Puerto Rico
    University of Puerto Rico School of Medicine, P.O. Box 365067, San Juan 00936, Puerto Rico)

  • Kelvin Quiñones-Laracuente

    (University of Puerto Rico School of Medicine, PO Box 365067, San Juan 00936, Puerto Rico
    University of Puerto Rico School of Medicine, P.O. Box 365067, San Juan 00936, Puerto Rico)

  • Gregory J. Quirk

    (University of Puerto Rico School of Medicine, PO Box 365067, San Juan 00936, Puerto Rico
    University of Puerto Rico School of Medicine, P.O. Box 365067, San Juan 00936, Puerto Rico)

Abstract

Dissociating early from late fear memory retrieval in rats reveals that while the projection from the prelimbic prefrontal cortex to the amygdala is critical for fear memory retrieval at early time points, a separate circuit involving the paraventricular region of the dorsal midline thalamus is critical for fear memory retrieval at late time points, establishing the paraventricular region as a critical maintenance/retrieval node during the transition from short- to long-term fear memory.

Suggested Citation

  • Fabricio H. Do-Monte & Kelvin Quiñones-Laracuente & Gregory J. Quirk, 2015. "A temporal shift in the circuits mediating retrieval of fear memory," Nature, Nature, vol. 519(7544), pages 460-463, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7544:d:10.1038_nature14030
    DOI: 10.1038/nature14030
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    Cited by:

    1. Masakazu Agetsuma & Issei Sato & Yasuhiro R. Tanaka & Luis Carrillo-Reid & Atsushi Kasai & Atsushi Noritake & Yoshiyuki Arai & Miki Yoshitomo & Takashi Inagaki & Hiroshi Yukawa & Hitoshi Hashimoto & J, 2023. "Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Jun Ma & John J. O’Malley & Malaz Kreiker & Yan Leng & Isbah Khan & Morgan Kindel & Mario A. Penzo, 2024. "Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Hiroyuki Miyawaki & Kenji Mizuseki, 2022. "De novo inter-regional coactivations of preconfigured local ensembles support memory," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    5. Jun Wang & Qian Yang & Xue Liu & Jie Li & Ya-Lan Wen & Yuzheng Hu & Tian-Le Xu & Shumin Duan & Han Xu, 2024. "The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Allen P. F. Chen & Lu Chen & Kaiyo W. Shi & Eileen Cheng & Shaoyu Ge & Qiaojie Xiong, 2023. "Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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