IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v519y2015i7544d10.1038_nature14030.html
   My bibliography  Save this article

A temporal shift in the circuits mediating retrieval of fear memory

Author

Listed:
  • Fabricio H. Do-Monte

    (University of Puerto Rico School of Medicine, PO Box 365067, San Juan 00936, Puerto Rico
    University of Puerto Rico School of Medicine, P.O. Box 365067, San Juan 00936, Puerto Rico)

  • Kelvin Quiñones-Laracuente

    (University of Puerto Rico School of Medicine, PO Box 365067, San Juan 00936, Puerto Rico
    University of Puerto Rico School of Medicine, P.O. Box 365067, San Juan 00936, Puerto Rico)

  • Gregory J. Quirk

    (University of Puerto Rico School of Medicine, PO Box 365067, San Juan 00936, Puerto Rico
    University of Puerto Rico School of Medicine, P.O. Box 365067, San Juan 00936, Puerto Rico)

Abstract

Dissociating early from late fear memory retrieval in rats reveals that while the projection from the prelimbic prefrontal cortex to the amygdala is critical for fear memory retrieval at early time points, a separate circuit involving the paraventricular region of the dorsal midline thalamus is critical for fear memory retrieval at late time points, establishing the paraventricular region as a critical maintenance/retrieval node during the transition from short- to long-term fear memory.

Suggested Citation

  • Fabricio H. Do-Monte & Kelvin Quiñones-Laracuente & Gregory J. Quirk, 2015. "A temporal shift in the circuits mediating retrieval of fear memory," Nature, Nature, vol. 519(7544), pages 460-463, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7544:d:10.1038_nature14030
    DOI: 10.1038/nature14030
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature14030
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature14030?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Masakazu Agetsuma & Issei Sato & Yasuhiro R. Tanaka & Luis Carrillo-Reid & Atsushi Kasai & Atsushi Noritake & Yoshiyuki Arai & Miki Yoshitomo & Takashi Inagaki & Hiroshi Yukawa & Hitoshi Hashimoto & J, 2023. "Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Jun Ma & John J. O’Malley & Malaz Kreiker & Yan Leng & Isbah Khan & Morgan Kindel & Mario A. Penzo, 2024. "Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Jun Wang & Qian Yang & Xue Liu & Jie Li & Ya-Lan Wen & Yuzheng Hu & Tian-Le Xu & Shumin Duan & Han Xu, 2024. "The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Hiroyuki Miyawaki & Kenji Mizuseki, 2022. "De novo inter-regional coactivations of preconfigured local ensembles support memory," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    6. Allen P. F. Chen & Lu Chen & Kaiyo W. Shi & Eileen Cheng & Shaoyu Ge & Qiaojie Xiong, 2023. "Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:519:y:2015:i:7544:d:10.1038_nature14030. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.