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The telomere length landscape of prostate cancer

Author

Listed:
  • Julie Livingstone

    (University of California
    University of California
    University of California
    University of California)

  • Yu-Jia Shiah

    (Ontario Institute for Cancer Research)

  • Takafumi N. Yamaguchi

    (University of California
    University of California
    University of California
    University of California)

  • Lawrence E. Heisler

    (Ontario Institute for Cancer Research)

  • Vincent Huang

    (Ontario Institute for Cancer Research)

  • Robert Lesurf

    (Ontario Institute for Cancer Research)

  • Tsumugi Gebo

    (University of California
    University of California
    University of California
    University of California)

  • Benjamin Carlin

    (University of California
    University of California
    University of California
    University of California)

  • Stefan Eng

    (University of California
    University of California
    University of California
    University of California)

  • Erik Drysdale

    (Ontario Institute for Cancer Research)

  • Jeffrey Green

    (Ontario Institute for Cancer Research)

  • Theodorus Kwast

    (University Health Network
    University Health Network)

  • Robert G. Bristow

    (University Health Network
    University of Toronto
    Manchester Cancer Research Centre)

  • Michael Fraser

    (University Health Network)

  • Paul C. Boutros

    (University of California
    University of California
    University of California
    University of California)

Abstract

Replicative immortality is a hallmark of cancer, and can be achieved through telomere lengthening and maintenance. Although the role of telomere length in cancer has been well studied, its association to genomic features is less well known. Here, we report the telomere lengths of 392 localized prostate cancer tumours and characterize their relationship to genomic, transcriptomic and proteomic features. Shorter tumour telomere lengths are associated with elevated genomic instability, including single-nucleotide variants, indels and structural variants. Genes involved in cell proliferation and signaling are correlated with tumour telomere length at all levels of the central dogma. Telomere length is also associated with multiple clinical features of a tumour. Longer telomere lengths in non-tumour samples are associated with a lower rate of biochemical relapse. In summary, we describe the multi-level integration of telomere length, genomics, transcriptomics and proteomics in localized prostate cancer.

Suggested Citation

  • Julie Livingstone & Yu-Jia Shiah & Takafumi N. Yamaguchi & Lawrence E. Heisler & Vincent Huang & Robert Lesurf & Tsumugi Gebo & Benjamin Carlin & Stefan Eng & Erik Drysdale & Jeffrey Green & Theodorus, 2021. "The telomere length landscape of prostate cancer," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27223-6
    DOI: 10.1038/s41467-021-27223-6
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    References listed on IDEAS

    as
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    2. Michael F. Berger & Michael S. Lawrence & Francesca Demichelis & Yotam Drier & Kristian Cibulskis & Andrey Y. Sivachenko & Andrea Sboner & Raquel Esgueva & Dorothee Pflueger & Carrie Sougnez & Robert , 2011. "The genomic complexity of primary human prostate cancer," Nature, Nature, vol. 470(7333), pages 214-220, February.
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    4. Michael Fraser & Veronica Y. Sabelnykova & Takafumi N. Yamaguchi & Lawrence E. Heisler & Julie Livingstone & Vincent Huang & Yu-Jia Shiah & Fouad Yousif & Xihui Lin & Andre P. Masella & Natalie S. Fox, 2017. "Genomic hallmarks of localized, non-indolent prostate cancer," Nature, Nature, vol. 541(7637), pages 359-364, January.
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