The ALT pathway generates telomere fusions that can be detected in the blood of cancer patients
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DOI: 10.1038/s41467-023-44287-8
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- Martin Peifer & Falk Hertwig & Frederik Roels & Daniel Dreidax & Moritz Gartlgruber & Roopika Menon & Andrea Krämer & Justin L. Roncaioli & Frederik Sand & Johannes M. Heuckmann & Fakhera Ikram & Rene, 2015. "Telomerase activation by genomic rearrangements in high-risk neuroblastoma," Nature, Nature, vol. 526(7575), pages 700-704, October.
- Yilong Li & Nicola D. Roberts & Jeremiah A. Wala & Ofer Shapira & Steven E. Schumacher & Kiran Kumar & Ekta Khurana & Sebastian Waszak & Jan O. Korbel & James E. Haber & Marcin Imielinski & Joachim We, 2020. "Patterns of somatic structural variation in human cancer genomes," Nature, Nature, vol. 578(7793), pages 112-121, February.
- Ofer Shoshani & Simon F. Brunner & Rona Yaeger & Peter Ly & Yael Nechemia-Arbely & Dong Hyun Kim & Rongxin Fang & Guillaume A. Castillon & Miao Yu & Julia S. Z. Li & Ying Sun & Mark H. Ellisman & Bing, 2021. "Chromothripsis drives the evolution of gene amplification in cancer," Nature, Nature, vol. 591(7848), pages 137-141, March.
- Viktor A. Adalsteinsson & Gavin Ha & Samuel S. Freeman & Atish D. Choudhury & Daniel G. Stover & Heather A. Parsons & Gregory Gydush & Sarah C. Reed & Denisse Rotem & Justin Rhoades & Denis Loginov & , 2017. "Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
- Michal Zalzman & Geppino Falco & Lioudmila V. Sharova & Akira Nishiyama & Marshall Thomas & Sung-Lim Lee & Carole A. Stagg & Hien G. Hoang & Hsih-Te Yang & Fred E. Indig & Robert P. Wersto & Minoru S., 2010. "Zscan4 regulates telomere elongation and genomic stability in ES cells," Nature, Nature, vol. 464(7290), pages 858-863, April.
- Lina Sieverling & Chen Hong & Sandra D. Koser & Philip Ginsbach & Kortine Kleinheinz & Barbara Hutter & Delia M. Braun & Isidro Cortés-Ciriano & Ruibin Xi & Rolf Kabbe & Peter J. Park & Roland Eils & , 2020. "Genomic footprints of activated telomere maintenance mechanisms in cancer," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
- Niek van Wietmarschen & Sriram Sridharan & William J. Nathan & Anthony Tubbs & Edmond M. Chan & Elsa Callen & Wei Wu & Frida Belinky & Veenu Tripathi & Nancy Wong & Kyla Foster & Javad Noorbakhsh & Ki, 2020. "Repeat expansions confer WRN dependence in microsatellite-unstable cancers," Nature, Nature, vol. 586(7828), pages 292-298, October.
- Mahmoud Ghandi & Franklin W. Huang & Judit Jané-Valbuena & Gregory V. Kryukov & Christopher C. Lo & E. Robert McDonald & Jordi Barretina & Ellen T. Gelfand & Craig M. Bielski & Haoxin Li & Kevin Hu & , 2019. "Next-generation characterization of the Cancer Cell Line Encyclopedia," Nature, Nature, vol. 569(7757), pages 503-508, May.
- Luiza Moore & Alex Cagan & Tim H. H. Coorens & Matthew D. C. Neville & Rashesh Sanghvi & Mathijs A. Sanders & Thomas R. W. Oliver & Daniel Leongamornlert & Peter Ellis & Ayesha Noorani & Thomas J. Mit, 2021. "The mutational landscape of human somatic and germline cells," Nature, Nature, vol. 597(7876), pages 381-386, September.
- Ofer Shoshani & Simon F. Brunner & Rona Yaeger & Peter Ly & Yael Nechemia-Arbely & Dong Hyun Kim & Rongxin Fang & Guillaume A. Castillon & Miao Yu & Julia S. Z. Li & Ying Sun & Mark H. Ellisman & Bing, 2021. "Publisher Correction: Chromothripsis drives the evolution of gene amplification in cancer," Nature, Nature, vol. 591(7850), pages 19-19, March.
- Pavithra Viswanath & Georgios Batsios & Joydeep Mukherjee & Anne Marie Gillespie & Peder E. Z. Larson & H. Artee Luchman & Joanna J. Phillips & Joseph F. Costello & Russell O. Pieper & Sabrina M. Rone, 2021. "Non-invasive assessment of telomere maintenance mechanisms in brain tumors," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
- Alexandre Nonneville & Roger R. Reddel, 2021. "Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX," Nature Communications, Nature, vol. 12(1), pages 1-4, December.
- Pedro A. Mateos-Gomez & Fade Gong & Nidhi Nair & Kyle M. Miller & Eros Lazzerini-Denchi & Agnel Sfeir, 2015. "Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination," Nature, Nature, vol. 518(7538), pages 254-257, February.
- Sally M. Dewhurst & Xiaotong Yao & Joel Rosiene & Huasong Tian & Julie Behr & Nazario Bosco & Kaori K. Takai & Titia de Lange & Marcin Imieliński, 2021. "Structural variant evolution after telomere crisis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
- Stephen Cristiano & Alessandro Leal & Jillian Phallen & Jacob Fiksel & Vilmos Adleff & Daniel C. Bruhm & Sarah Østrup Jensen & Jamie E. Medina & Carolyn Hruban & James R. White & Doreen N. Palsgrove &, 2019. "Genome-wide cell-free DNA fragmentation in patients with cancer," Nature, Nature, vol. 570(7761), pages 385-389, June.
- Rajika Arora & Yongwoo Lee & Harry Wischnewski & Catherine M. Brun & Tobias Schwarz & Claus M. Azzalin, 2014. "RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
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