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A giant NLR gene confers broad-spectrum resistance to Phytophthora sojae in soybean

Author

Listed:
  • Weidong Wang

    (Purdue University)

  • Liyang Chen

    (Purdue University)

  • Kevin Fengler

    (Corteva Agriscience™)

  • Joy Bolar

    (Corteva Agriscience™)

  • Victor Llaca

    (Corteva Agriscience™)

  • Xutong Wang

    (Purdue University)

  • Chancelor B. Clark

    (Purdue University)

  • Tomara J. Fleury

    (Purdue University
    USDA, ARS)

  • Jon Myrvold

    (Corteva Agriscience™)

  • David Oneal

    (Corteva Agriscience™)

  • Maria Magdalena Dyk

    (Corteva Agriscience™)

  • Ashley Hudson

    (Corteva Agriscience™)

  • Jesse Munkvold

    (Corteva Agriscience™)

  • Andy Baumgarten

    (Corteva Agriscience™)

  • Jeff Thompson

    (Corteva Agriscience™)

  • Guohong Cai

    (Purdue University
    USDA, ARS)

  • Oswald Crasta

    (Corteva Agriscience™
    R&D, Equinom, Inc.)

  • Rajat Aggarwal

    (Corteva Agriscience™)

  • Jianxin Ma

    (Purdue University)

Abstract

Phytophthora root and stem rot caused by P. sojae is a destructive soybean soil-borne disease found worldwide. Discovery of genes conferring broad-spectrum resistance to the pathogen is a need to prevent the outbreak of the disease. Here, we show that soybean Rps11 is a 27.7-kb nucleotide-binding site-leucine-rich repeat (NBS-LRR or NLR) gene conferring broad-spectrum resistance to the pathogen. Rps11 is located in a genomic region harboring a cluster of large NLR genes of a single origin in soybean, and is derived from rounds of unequal recombination. Such events result in promoter fusion and LRR expansion that may contribute to the broad resistance spectrum. The NLR gene cluster exhibits drastic structural diversification among phylogenetically representative varieties, including gene copy number variation ranging from five to 23 copies, and absence of allelic copies of Rps11 in any of the non-Rps11-donor varieties examined, exemplifying innovative evolution of NLR genes and NLR gene clusters.

Suggested Citation

  • Weidong Wang & Liyang Chen & Kevin Fengler & Joy Bolar & Victor Llaca & Xutong Wang & Chancelor B. Clark & Tomara J. Fleury & Jon Myrvold & David Oneal & Maria Magdalena Dyk & Ashley Hudson & Jesse Mu, 2021. "A giant NLR gene confers broad-spectrum resistance to Phytophthora sojae in soybean," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26554-8
    DOI: 10.1038/s41467-021-26554-8
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    References listed on IDEAS

    as
    1. Jeremy Schmutz & Steven B. Cannon & Jessica Schlueter & Jianxin Ma & Therese Mitros & William Nelson & David L. Hyten & Qijian Song & Jay J. Thelen & Jianlin Cheng & Dong Xu & Uffe Hellsten & Gregory , 2010. "Genome sequence of the palaeopolyploid soybean," Nature, Nature, vol. 463(7278), pages 178-183, January.
    2. Min Xie & Claire Yik-Lok Chung & Man-Wah Li & Fuk-Ling Wong & Xin Wang & Ailin Liu & Zhili Wang & Alden King-Yung Leung & Tin-Hang Wong & Suk-Wah Tong & Zhixia Xiao & Kejing Fan & Ming-Sin Ng & Xinpen, 2019. "A reference-grade wild soybean genome," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    3. Jeremy Schmutz & Steven B. Cannon & Jessica Schlueter & Jianxin Ma & Therese Mitros & William Nelson & David L. Hyten & Qijian Song & Jay J. Thelen & Jianlin Cheng & Dong Xu & Uffe Hellsten & Gregory , 2010. "Erratum: Genome sequence of the palaeopolyploid soybean," Nature, Nature, vol. 465(7294), pages 120-120, May.
    4. Shujun Ou & Jianing Liu & Kapeel M. Chougule & Arkarachai Fungtammasan & Arun S. Seetharam & Joshua C. Stein & Victor Llaca & Nancy Manchanda & Amanda M. Gilbert & Sharon Wei & Chen-Shan Chin & David , 2020. "Effect of sequence depth and length in long-read assembly of the maize inbred NC358," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
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    Cited by:

    1. Austin G. McCoy & Richard R. Belanger & Carl A. Bradley & Daniel G. Cerritos-Garcia & Vinicius C. Garnica & Loren J. Giesler & Pablo E. Grijalba & Eduardo Guillin & Maria A. Henriquez & Yong Min Kim &, 2023. "A global-temporal analysis on Phytophthora sojae resistance-gene efficacy," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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