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Astral hydrogels mimic tissue mechanics by aster-aster interpenetration

Author

Listed:
  • Qingqiao Xie

    (South China University of Technology
    South China University of Technology)

  • Yuandi Zhuang

    (Jinan University)

  • Gaojun Ye

    (Jinan University)

  • Tiankuo Wang

    (Nanjing University)

  • Yi Cao

    (Nanjing University)

  • Lingxiang Jiang

    (South China University of Technology
    South China University of Technology)

Abstract

Many soft tissues are compression-stiffening and extension-softening in response to axial strains, but common hydrogels are either inert (for ideal chains) or tissue-opposite (for semiflexible polymers). Herein, we report a class of astral hydrogels that are structurally distinct from tissues but mechanically tissue-like. Specifically, hierarchical self-assembly of amphiphilic gemini molecules produces radial asters with a common core and divergently growing, semiflexible ribbons; adjacent asters moderately interpenetrate each other via interlacement of their peripheral ribbons to form a gel network. Resembling tissues, the astral gels stiffen in compression and soften in extension with all the experimental data across different gel compositions collapsing onto a single master curve. We put forward a minimal model to reproduce the master curve quantitatively, underlying the determinant role of aster-aster interpenetration. Compression significantly expands the interpenetration region, during which the number of effective crosslinks is increased and the network strengthened, while extension does the opposite. Looking forward, we expect this unique mechanism of interpenetration to provide a fresh perspective for designing and constructing mechanically tissue-like materials.

Suggested Citation

  • Qingqiao Xie & Yuandi Zhuang & Gaojun Ye & Tiankuo Wang & Yi Cao & Lingxiang Jiang, 2021. "Astral hydrogels mimic tissue mechanics by aster-aster interpenetration," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24663-y
    DOI: 10.1038/s41467-021-24663-y
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    References listed on IDEAS

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    1. R. Oda & I. Huc & M. Schmutz & S. J. Candau & F. C. MacKintosh, 1999. "Tuning bilayer twist using chiral counterions," Nature, Nature, vol. 399(6736), pages 566-569, June.
    2. Cornelis Storm & Jennifer J. Pastore & F. C. MacKintosh & T. C. Lubensky & Paul A. Janmey, 2005. "Nonlinear elasticity in biological gels," Nature, Nature, vol. 435(7039), pages 191-194, May.
    3. David G. Grier, 2003. "A revolution in optical manipulation," Nature, Nature, vol. 424(6950), pages 810-816, August.
    4. Lingxiang Jiang & Qingqiao Xie & Boyce Tsang & Steve Granick, 2019. "Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
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    Cited by:

    1. Yiqiu Zhao & Haitao Hu & Yulu Huang & Hanqing Liu & Caishan Yan & Chang Xu & Rui Zhang & Yifan Wang & Qin Xu, 2024. "Elasticity-controlled jamming criticality in soft composite solids," Nature Communications, Nature, vol. 15(1), pages 1-8, December.

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