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Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations

Author

Listed:
  • Lingxiang Jiang

    (Jinan University)

  • Qingqiao Xie

    (Jinan University)

  • Boyce Tsang

    (University of Illinois)

  • Steve Granick

    (Institute for Basic Science (IBS)
    Departments of Chemistry and Physics, UNIST)

Abstract

Polymer networks are fundamental from cellular biology to plastics technology but their intrinsic inhomogeneity is masked by the usual ensemble-averaged measurements. Here, we construct direct maps of crosslinks—symbolic depiction of spatially-distributed elements highlighting their physical features and the relationships between them—in an actin network. We selectively label crosslinks with fluorescent markers, track their thermal fluctuations, and characterize the local elasticity and cross-correlations between crosslinks. Such maps display massive heterogeneity, reveal abundant anticorrelations, and may contribute to address how local responses scale up to produce macroscopic elasticity. Single-crosslink microscopy offers a general, microscopic framework to better understand crosslinked molecular networks in undeformed or strained states.

Suggested Citation

  • Lingxiang Jiang & Qingqiao Xie & Boyce Tsang & Steve Granick, 2019. "Single-crosslink microscopy in a biopolymer network dissects local elasticity from molecular fluctuations," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11313-7
    DOI: 10.1038/s41467-019-11313-7
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    Cited by:

    1. Qingqiao Xie & Yuandi Zhuang & Gaojun Ye & Tiankuo Wang & Yi Cao & Lingxiang Jiang, 2021. "Astral hydrogels mimic tissue mechanics by aster-aster interpenetration," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    2. Kaikai Zheng & Yifan Zhang & Bo Li & Steve Granick, 2023. "Phosphorescent extensophores expose elastic nonuniformity in polymer networks," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    3. Xiaobin Dai & Xuanyu Zhang & Lijuan Gao & Ziyang Xu & Li-Tang Yan, 2022. "Topology mediates transport of nanoparticles in macromolecular networks," Nature Communications, Nature, vol. 13(1), pages 1-8, December.

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