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Heavy Metals Stimulate Human LINE-1 Retrotransposition

Author

Listed:
  • Shubha P. Kale

    (Dept. of Biology, Xavier University of Louisiana, 1 Drexel Dr. New Orleans, LA 70125, USA)

  • Lakisha Moore

    (Dept. of Biology, Xavier University of Louisiana, 1 Drexel Dr. New Orleans, LA 70125, USA)

  • Prescott L. Deininger

    (Tulane Cancer Center SL-66, Dept. of Epidemiology, Tulane University Health Sciences Center, 1430 Tulane Ave., New Orleans, LA 70112, USA)

  • Astrid M. Roy-Engel

    (Tulane Cancer Center SL-66, Dept. of Epidemiology, Tulane University Health Sciences Center, 1430 Tulane Ave., New Orleans, LA 70112, USA)

Abstract

L1 and Alu elements are among the most active retroposons (mobile elements) in the human genome. Several human diseases, including certain forms of breast cancer and leukemia, are associated with L1 and Alu insertions in functionally important areas of the genome. We present data demonstrating that environmental pollutants, such as heavy metals, can stimulate L1 retrotransposition in a tissue culture system using two different types of assays. The response to these agents was equivalent when using a cell line with a stably integrated L1 vector (genomic) or a by introducing the L1 vector by transient transfection (episomal) of the cell. Reproducible results showed that mercury (HgS), cadmium (CdS), and nickel (NiO) increase the activity of L1 by an average of three (3) fold p

Suggested Citation

  • Shubha P. Kale & Lakisha Moore & Prescott L. Deininger & Astrid M. Roy-Engel, 2005. "Heavy Metals Stimulate Human LINE-1 Retrotransposition," IJERPH, MDPI, vol. 2(1), pages 1-10, April.
    • Handle: RePEc:gam:jijerp:v:2:y:2005:i:1:p:14-23:d:2707
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    References listed on IDEAS

    as
    1. Déborah Bourc'his & Timothy H. Bestor, 2004. "Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L," Nature, Nature, vol. 431(7004), pages 96-99, September.
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    Cited by:

    1. Shubha P. Kale & Mary C. Carmichael & Kelley Harris & Astrid M. Roy-Engel, 2006. "The L1 Retrotranspositional Stimulation by Particulate and Soluble Cadmium Exposure is Independent of the Generation of DNA Breaks," IJERPH, MDPI, vol. 3(2), pages 1-8, June.

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    More about this item

    Keywords

    L1; retrotransposition; cancer; genetic instability; heavy metals;
    All these keywords.

    JEL classification:

    • L1 - Industrial Organization - - Market Structure, Firm Strategy, and Market Performance

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