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Investigating the Interplay of Toxic Metals and Essential Elements in Liver Disease

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  • Aderonke Gbemi Adetunji

    (Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA
    Environmental Health and Disease Laboratory, North Carolina A&T State University, Greensboro, NC 27411, USA)

  • Emmanuel Obeng-Gyasi

    (Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA
    Environmental Health and Disease Laboratory, North Carolina A&T State University, Greensboro, NC 27411, USA)

Abstract

Liver diseases, including non-alcoholic fatty liver disease (NAFLD), are a growing global health issue. Environmental exposure to toxic metals can harm the liver, increasing the risk of NAFLD. Essential elements are vital for liver health, but imbalances or deficiencies can contribute to the development of NAFLD. Therefore, understanding the interplay between toxic metals and essential elements in liver disease is important. This study aims to assess the individual and combined effects of toxic metals (lead(Pb), cadmium (Cd), mercury (Hg)), and essential elements (manganese and selenium) on the risk of liver disease. Methods: We assessed the individual and combined effects of Pb, Cd, Hg, manganese (Mn), and selenium (Se) on liver disease risk using data from the National Health and Nutrition Examination Survey between 2017 and 2018. We performed descriptive statistics and linear regression analysis and then utilized Bayesian Kernel Machine Regression (BKMR) techniques such as univariate, bivariate, and overall effect analysis. BKMR enabled the assessment of non-linear exposure–response functions and interactions between metals and essential elements. Posterior Inclusion Probabilities (PIPs) were calculated to determine the importance of each metal and essential element in contributing to liver disease. Regarding our study results, the regression analysis of liver injury biomarkers ALT, AST, ALP, GGT, total bilirubin, and the FLI—an indicator of NAFLD—with toxic metals and essential elements, adjusting for covariates such as age, sex, BMI, alcohol consumption, ethnicity, income, and smoking status, demonstrated the differential effects of these contaminants on the markers of interest. Our BKMR analysis provided further insights. For instance, the PIP results underscored Pb’s consistent importance in contributing to liver disease (PIP = 1.000), followed by Hg (PIP = 0.9512), Cd (PIP = 0.5796), Se (PIP = 0.5572), and Mn (PIP = 0.4248). Our univariate analysis showed a positive trend with Pb, while other exposures were relatively flat. Our analysis of the single-variable effects of toxic metals and essential elements on NAFLD also revealed that Pb significantly affected the risk of NAFLD. Our bivariate analysis found a positive (toxic) trend when Pb was combined with other metals and essential elements. For the overall exposure effect of exposure to all the contaminants together, the estimated risk of NAFLD showed a steady increase from the 60th to the 75th percentile. In conclusion, our study indicates that Pb exposure, when combined with other toxic metals and essential elements, plays a significant role in bringing about adverse liver disease outcomes.

Suggested Citation

  • Aderonke Gbemi Adetunji & Emmanuel Obeng-Gyasi, 2024. "Investigating the Interplay of Toxic Metals and Essential Elements in Liver Disease," IJERPH, MDPI, vol. 21(6), pages 1-18, June.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:6:p:762-:d:1413228
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    References listed on IDEAS

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    1. Issah Haruna & Emmanuel Obeng-Gyasi, 2024. "Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Chronic Kidney Disease," IJERPH, MDPI, vol. 21(4), pages 1-22, April.
    2. Emmanuel Obeng-Gyasi, 2018. "Hepatobiliary Related Outcomes in US Adults Exposed to Lead," 2018 Stata Conference 81, Stata Users Group.
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