IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i8p2909-d349151.html
   My bibliography  Save this article

Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers

Author

Listed:
  • Hsin-Liang Liu

    (Division of Internal Medicine, Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Hung-Yi Chuang

    (Department of Public Health, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    Department of Environmental and Occupational Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan)

  • Chien-Ning Hsu

    (Department of Pharmacy in Kaohsiung Chang Gung Memorial Hospital, and School of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Su-Shin Lee

    (Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Chen-Cheng Yang

    (Department of Environmental and Occupational Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan)

  • Kuan-Ting Liu

    (Division of Internal Medicine, Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

Abstract

Chronic exposure to lead is neurotoxic to the human peripheral sensory system. Variant vitamin D receptor (VDR) genes and polymorphisms of metallothioneins (MTs) are associated with different outcomes following lead toxicity. However, no evidence of a relationship between lead neurotoxicity and polymorphisms has previously been presented. In this study, we investigated the relationship between the polymorphisms of VDR , MT1A , and MT2A genes and lead toxicity following chronic occupational lead exposure. We measured vibration perception thresholds (VPT) and current perception thresholds (CPT) in 181 workers annually for five years. The outcome variables were correlated to the subject’s index of long-term lead exposure. Polymorphisms of VDR , MT1A , and MT2A were defined. The potential confounders, including age, sex, height, smoking, alcohol consumption, and working life span, were also collected and analyzed using linear regression. The regression coefficients of some gene polymorphisms were at least 20 times larger than regression coefficients of time-weighted index of cumulative blood lead (TWICL) measures. All regression coefficients of TWICL increased slightly. MT1A rs11640851 (AA/CC) was associated with a statistically significant difference in all neurological outcomes except hand and foot VPT. MT1A rs8052394 was associated with statistically significant differences in hand and foot CPT 2000 Hz. In MT2A rs10636, those with the C allele showed a greater effect on hand CPT than those with the G allele. Among the VDR gene polymorphisms, the Apa rs7975232 (CC/AA) single nucleotide polymorphism was associated with the greatest difference in hand CPT. MT2A rs28366003 appeared to have a neural protective effect, whereas Apa (rs7975232) of VDR and MT2A rs10636 increased the neurotoxicity as measured by CPT in the hands. MT1A rs8052394 had a protective effect on large myelinated nerves. MT1A rs11640851 was associated with susceptibility to neurotoxicity.

Suggested Citation

  • Hsin-Liang Liu & Hung-Yi Chuang & Chien-Ning Hsu & Su-Shin Lee & Chen-Cheng Yang & Kuan-Ting Liu, 2020. "Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers," IJERPH, MDPI, vol. 17(8), pages 1-12, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2909-:d:349151
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/8/2909/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/8/2909/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Emmanuel Obeng-Gyasi, 2018. "Hepatobiliary Related Outcomes in US Adults Exposed to Lead," 2018 Stata Conference 81, Stata Users Group.
    2. Pei Jiang & Wen-Ye Zhu & Xin He & Mi-Mi Tang & Rui-Li Dang & Huan-De Li & Ying Xue & Li-Hong Zhang & Yan-Qin Wu & Ling-Juan Cao, 2015. "Association between Vitamin D Receptor Gene Polymorphisms with Childhood Temporal Lobe Epilepsy," IJERPH, MDPI, vol. 12(11), pages 1-10, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ewa Wojciechowska & Nicole Nawrot & Jolanta Walkusz-Miotk & Karolina Matej-Łukowicz & Ksenia Pazdro, 2019. "Heavy Metals in Sediments of Urban Streams: Contamination and Health Risk Assessment of Influencing Factors," Sustainability, MDPI, vol. 11(3), pages 1-14, January.
    2. Shuai Gu & Bitian Fu & Ji Whan Ahn, 2020. "Simultaneous Removal of Residual Sulfate and Heavy Metals from Spent Electrolyte of Lead-Acid Battery after Precipitation and Carbonation," Sustainability, MDPI, vol. 12(3), pages 1-11, February.
    3. Gabriel M. Filippelli & Jessica Adamic & Deborah Nichols & John Shukle & Emeline Frix, 2018. "Mapping the Urban Lead Exposome: A Detailed Analysis of Soil Metal Concentrations at the Household Scale Using Citizen Science," IJERPH, MDPI, vol. 15(7), pages 1-11, July.
    4. Aderonke Gbemi Adetunji & Emmanuel Obeng-Gyasi, 2024. "Investigating the Interplay of Toxic Metals and Essential Elements in Liver Disease," IJERPH, MDPI, vol. 21(6), pages 1-18, June.
    5. Nurhayati A. Prihartono & Ratna Djuwita & Putri B. Mahmud & Budi Haryanto & Helda Helda & Tri Yunis Miko Wahyono & Timothy Dignam, 2019. "Prevalence of Blood Lead among Children Living in Battery Recycling Communities in Greater Jakarta, Indonesia," IJERPH, MDPI, vol. 16(7), pages 1-11, April.
    6. Shamshad Karatela & Christin Coomarasamy & Janis Paterson & Neil I. Ward, 2019. "Household Smoking Status and Heavy Metal Concentrations in Toenails of Children," IJERPH, MDPI, vol. 16(20), pages 1-12, October.
    7. Shiqi Tian & Shijie Wang & Xiaoyong Bai & Dequan Zhou & Guangjie Luo & Jinfeng Wang & Mingming Wang & Qian Lu & Yujie Yang & Zeyin Hu & Chaojun Li & Yuanhong Deng, 2019. "Hyperspectral Prediction Model of Metal Content in Soil Based on the Genetic Ant Colony Algorithm," Sustainability, MDPI, vol. 11(11), pages 1-21, June.
    8. Emmanuel Obeng-Gyasi & Rodrigo X. Armijos & M. Margaret Weigel & Gabriel M. Filippelli & M. Aaron Sayegh, 2018. "Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead," IJERPH, MDPI, vol. 15(4), pages 1-16, April.
    9. Jianhong Zhang & Min Wang & Keming Yang & Yanru Li & Yaxing Li & Bing Wu & Qianqian Han, 2022. "The New Hyperspectral Analysis Method for Distinguishing the Types of Heavy Metal Copper and Lead Pollution Elements," IJERPH, MDPI, vol. 19(13), pages 1-26, June.
    10. Kyriaki Kelektsoglou & Dimitra Karali & Alexandros Stavridis & Glykeria Loupa, 2018. "Efficiency of the Air-Pollution Control System of a Lead-Acid-Battery Recycling Industry," Energies, MDPI, vol. 11(12), pages 1-11, December.
    11. Chien-Juan Chen & Ting-Yi Lin & Chao-Ling Wang & Chi-Kung Ho & Hung-Yi Chuang & Hsin-Su Yu, 2019. "Interactive Effects between Chronic Lead Exposure and the Homeostatic Iron Regulator Transport HFE Polymorphism on the Human Red Blood Cell Mean Corpuscular Volume (MCV)," IJERPH, MDPI, vol. 16(3), pages 1-9, January.
    12. Nisha Naicker & Pieter De Jager & Shan Naidoo & Angela Mathee, 2018. "Is There a Relationship between Lead Exposure and Aggressive Behavior in Shooters?," IJERPH, MDPI, vol. 15(7), pages 1-10, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2909-:d:349151. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.