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Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents

Author

Listed:
  • Aozhe Wang

    (Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China
    These authors contributed equally to this work.)

  • Haifeng Zhang

    (Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China
    These authors contributed equally to this work.)

  • Jianming Liu

    (School of Competitive Sports, Beijing Sport University, Beijing 100084, China
    These authors contributed equally to this work.)

  • Zhiyi Yan

    (Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China)

  • Yaqi Sun

    (Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China)

  • Wantang Su

    (Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China)

  • Ji-Guo Yu

    (Department of Community Medicine and Rehabilitation, Faculty of Medicine, Umeå University, 901 87 Umeå, Sweden)

  • Jing Mi

    (School of Competitive Sports, Beijing Sport University, Beijing 100084, China)

  • Li Zhao

    (Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China)

Abstract

Lipids play an important role in coordinating and regulating metabolic and inflammatory processes. Sprint interval training (SIT) is widely used to improve sports performance and health outcomes, but the current understanding of SIT-induced lipid metabolism and the corresponding systemic inflammatory status modification remains controversial and limited, especially in male adolescents. To answer these questions, twelve untrained male adolescents were recruited and underwent 6 weeks of SIT. The pre- and post-training testing included analyses of peak oxygen consumption (VO 2 peak), biometric data (weight and body composition), serum biochemical parameters (fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerol, testosterone, and cortisol), inflammatory markers, and targeted lipidomics. After the 6-week SIT, the serum C-reactive protein (CRP), interleukin (IL)-1β, IL-2, IL-4, IL-10, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β significantly decreased ( p < 0.05), whereas IL-6 and IL-10/TNF-α significantly increased ( p < 0.05). In addition, the targeted lipidomics revealed changes in 296 lipids, of which 33 changed significantly ( p < 0.05, fold change > 1.2 or <1/1.2). The correlation analysis revealed that the changes in the inflammatory markers were closely correlated with the changes in some of the lipids, such as LPC, HexCer, and FFA. In conclusion, the 6-week SIT induced significant changes in the inflammatory markers and circulating lipid composition, offering health benefits to the population.

Suggested Citation

  • Aozhe Wang & Haifeng Zhang & Jianming Liu & Zhiyi Yan & Yaqi Sun & Wantang Su & Ji-Guo Yu & Jing Mi & Li Zhao, 2023. "Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents," IJERPH, MDPI, vol. 20(4), pages 1-15, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3329-:d:1067845
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    References listed on IDEAS

    as
    1. Meng Cao & Minghui Quan & Jie Zhuang, 2019. "Effect of High-Intensity Interval Training versus Moderate-Intensity Continuous Training on Cardiorespiratory Fitness in Children and Adolescents: A Meta-Analysis," IJERPH, MDPI, vol. 16(9), pages 1-13, April.
    2. Sigbjørn Litleskare & Eystein Enoksen & Marit Sandvei & Line Støen & Trine Stensrud & Egil Johansen & Jørgen Jensen, 2020. "Sprint Interval Running and Continuous Running Produce Training Specific Adaptations, Despite a Similar Improvement of Aerobic Endurance Capacity—A Randomized Trial of Healthy Adults," IJERPH, MDPI, vol. 17(11), pages 1-12, May.
    3. Haochong Liu & Bo Leng & Qian Li & Ye Liu & Dapeng Bao & Yixiong Cui, 2021. "The Effect of Eight-Week Sprint Interval Training on Aerobic Performance of Elite Badminton Players," IJERPH, MDPI, vol. 18(2), pages 1-11, January.
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