IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i2p985-d725882.html
   My bibliography  Save this article

The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial

Author

Listed:
  • Biagio Rapone

    (Interdisciplinary Department of Medicine, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Elisabetta Ferrara

    (Complex Operative Unit of Odontostomatology, Hospital S.S. Annunziata, 66100 Chieti, Italy)

  • Luigi Santacroce

    (Complex Operative Unit of Odontostomatology, Hospital S.S. Annunziata, 66100 Chieti, Italy)

  • Skender Topi

    (Department of Clinical Disciplines, School of Technical Medical Sciences, University A. Xhuvani, 3001 Elbasan, Albania)

  • Antonio Gnoni

    (Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Gianna Dipalma

    (Interdisciplinary Department of Medicine, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Antonio Mancini

    (Interdisciplinary Department of Medicine, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Marina Di Domenico

    (Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy)

  • Gianluca Martino Tartaglia

    (UOC Maxillo-Facial Surgery and Dentistry, Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, University of Milan, 20100 Milan, Italy)

  • Antonio Scarano

    (Department of Oral Science, Nano and Biotechnology and CeSi-Met University of Chieti-Pescara, 66100 Chieti, Italy
    These authors contributed equally to this work.)

  • Francesco Inchingolo

    (Interdisciplinary Department of Medicine, “Aldo Moro” University of Bari, 70121 Bari, Italy
    These authors contributed equally to this work.)

Abstract

Background: the establishment of periodontitis is regulated by the primary etiological factor and several individual conditions including the immune response mechanism of the host and individual genetic factors. It results when the oral homeostasis is interrupted, and biological reactions favor the development and progression of periodontal tissues damage. Different strategies have been explored for reinforcing the therapeutic effect of non-surgical periodontal treatment of periodontal tissue damage. Gaseous ozone therapy has been recognized as a promising antiseptic adjuvant, because of its immunostimulating, antimicrobial, antihypoxic, and biosynthetic effects. Then, we hypothesized that the adjunct of gaseous ozone therapy to standard periodontal treatment may be leveraged to promote the tissue healing response. Methods: to test this hypothesis, we conducted a prospective randomized study comparing non-surgical periodontal treatment plus gaseous ozone therapy to standard therapy. A total of 90 healthy individuals with moderate or severe generalized periodontitis were involved in the study. The trial was conducted from September 2019 to October 2020. Forty-five patients were randomized to receive scaling and root-planning (SRP) used as conventional non-surgical periodontal therapy plus gaseous ozone therapy (GROUP A); forty-five were allocated to standard treatment (GROUP B). The endpoint was defined as the periodontal response rate after the application of the ozone therapy at 3 months and 6 months, defined as no longer meeting the criteria for active periodontitis. Statistical analysis was performed employing SPSS v.18 Chicago: SPSS Inc. Results: periodontal parameters differed significantly between patients treated with the two distinct procedures at 3 months ( p ≤ 0.005); a statistically significant difference between groups was observed from baseline in the CAL ( p ≤ 0.0001), PPD ( p ≤ 0.0001) and BOP ( p ≤ 0.0001) scores. Conclusions: The present study suggests that SRP combined with ozone therapy in the treatment of periodontitis revealed an improved outcome than SRP alone.

Suggested Citation

  • Biagio Rapone & Elisabetta Ferrara & Luigi Santacroce & Skender Topi & Antonio Gnoni & Gianna Dipalma & Antonio Mancini & Marina Di Domenico & Gianluca Martino Tartaglia & Antonio Scarano & Francesco , 2022. "The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial," IJERPH, MDPI, vol. 19(2), pages 1-14, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:985-:d:725882
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/2/985/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/2/985/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Field, Andy Peter Professor & Wilcox, Rand R., 2017. "Robust statistical methods: a primer for clinical psychology and experimental psychopathology researchers," OSF Preprints v3nz4, Center for Open Science.
    2. Nicola Montemurro & Paolo Perrini & Biagio Rapone, 2020. "Clinical Risk and Overall Survival in Patients with Diabetes Mellitus, Hyperglycemia and Glioblastoma Multiforme. A Review of the Current Literature," IJERPH, MDPI, vol. 17(22), pages 1-18, November.
    3. Camilla Preda & Andrea Butera & Silvia Pelle & Eleonora Pautasso & Alessandro Chiesa & Francesca Esposito & Giacomo Oldoini & Andrea Scribante & Anna Maria Genovesi & Saverio Cosola, 2021. "The Efficacy of Powered Oscillating Heads vs. Powered Sonic Action Heads Toothbrushes to Maintain Periodontal and Peri-Implant Health: A Narrative Review," IJERPH, MDPI, vol. 18(4), pages 1-17, February.
    4. Antonio Scarano & Francesco Inchingolo & Biagio Rapone & Felice Festa & Sergio Rexhep Tari & Felice Lorusso, 2021. "Protective Face Masks: Effect on the Oxygenation and Heart Rate Status of Oral Surgeons during Surgery," IJERPH, MDPI, vol. 18(5), pages 1-10, February.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kacper Nijakowski & Dawid Gruszczyński & Julia Kolasińska & Dariusz Kopała & Anna Surdacka, 2022. "Periodontal Disease in Patients with Psoriasis: A Systematic Review," IJERPH, MDPI, vol. 19(18), pages 1-15, September.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Giulia Casu & Valentina Hlebec & Licia Boccaletti & Irena Bolko & Alessandra Manattini & Elizabeth Hanson, 2021. "Promoting Mental Health and Well-Being among Adolescent Young Carers in Europe: A Randomized Controlled Trial Protocol," IJERPH, MDPI, vol. 18(4), pages 1-23, February.
    2. Assunta Patano & Nunzio Cirulli & Matteo Beretta & Paola Plantamura & Alessio Danilo Inchingolo & Angelo Michele Inchingolo & Ioana Roxana Bordea & Giuseppina Malcangi & Grazia Marinelli & Antonio Sca, 2021. "Education Technology in Orthodontics and Paediatric Dentistry during the COVID-19 Pandemic: A Systematic Review," IJERPH, MDPI, vol. 18(11), pages 1-27, June.
    3. Mirja Möhn & Julia Camilla Bulski & Norbert Krämer & Alexander Rahman & Nelly Schulz-Weidner, 2021. "Management of Amelogenesis Imperfecta in Childhood: Two Case Reports," IJERPH, MDPI, vol. 18(13), pages 1-9, July.
    4. Shan Jiang & Lin Wang & Yuhang Cheng, 2023. "Unrevealing the Mediating Mechanisms Between Material Deprivation and Children’s Life Satisfaction: Empirical Evidence from the International Survey of Children’s Well-Being," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 18(2), pages 893-914, April.
    5. Biagio Rapone & Elisabetta Ferrara & Massimo Corsalini & Erda Qorri & Ilaria Converti & Felice Lorusso & Maurizio Delvecchio & Antonio Gnoni & Salvatore Scacco & Antonio Scarano, 2021. "Inflammatory Status and Glycemic Control Level of Patients with Type 2 Diabetes and Periodontitis: A Randomized Clinical Trial," IJERPH, MDPI, vol. 18(6), pages 1-16, March.
    6. Hiroo Kawahara & Miho Inoue & Kazuo Okura & Masamitsu Oshima & Yoshizo Matsuka, 2021. "Risk Factors for Tooth Loss in Patients with ≥25 Remaining Teeth Undergoing Mid-Long-Term Maintenance: A Retrospective Study," IJERPH, MDPI, vol. 18(13), pages 1-8, July.
    7. Nicola Montemurro & Sara Condino & Nadia Cattari & Renzo D’Amato & Vincenzo Ferrari & Fabrizio Cutolo, 2021. "Augmented Reality-Assisted Craniotomy for Parasagittal and Convexity En Plaque Meningiomas and Custom-Made Cranio-Plasty: A Preliminary Laboratory Report," IJERPH, MDPI, vol. 18(19), pages 1-13, September.
    8. Wang, Lin & Ge, Ting & Gao, Xiaojing, 2024. "Unveiling the protective role of school engagement: Mitigating cyberbullying perpetration through mastery and student-student relationship," Children and Youth Services Review, Elsevier, vol. 162(C).
    9. Siyun Sun & Yingyuan Chen & Sen Mu & Bo Jiang & Yiwei Lin & Tian Gao & Ling Qiu, 2021. "The Psychological Restorative Effects of Campus Environments on College Students in the Context of the COVID-19 Pandemic: A Case Study at Northwest A&F University, Shaanxi, China," IJERPH, MDPI, vol. 18(16), pages 1-12, August.
    10. Lourenção, Marina & de Moura Engracia Giraldi, Janaina & de Oliveira, Jorge Henrique Caldeira, 2020. "Destination advertisement semiotic signs: Analysing tourists' visual attention and perceived ad effectiveness," Annals of Tourism Research, Elsevier, vol. 84(C).
    11. Izabela Wojtasz & Szczepan Cofta & Paweł Czudaj & Krystyna Jaracz & Radosław Kaźmierski, 2022. "Effect of Face Masks on Blood Saturation, Heart Rate, and Well-Being Indicators in Health Care Providers Working in Specialized COVID-19 Center," IJERPH, MDPI, vol. 19(3), pages 1-9, January.
    12. Mariam M. Elgendi & Sherry H. Stewart & Danika I. DesRoches & Penny Corkum & Raquel Nogueira-Arjona & S. Hélène Deacon, 2022. "Division of Labour and Parental Mental Health and Relationship Well-Being during COVID-19 Pandemic-Mandated Homeschooling," IJERPH, MDPI, vol. 19(24), pages 1-34, December.
    13. Renske van der Cruijsen & Jennifer Murphy & Geoffrey Bird, 2019. "Alexithymic traits can explain the association between puberty and symptoms of depression and anxiety in adolescent females," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-17, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:985-:d:725882. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.