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Clinical Risk and Overall Survival in Patients with Diabetes Mellitus, Hyperglycemia and Glioblastoma Multiforme. A Review of the Current Literature

Author

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  • Nicola Montemurro

    (Department of Neurosurgery, Azienda Ospedaliera Universitaria Pisana (AOUP), 56126 Pisa, Italy
    Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, 56126 Pisa, Italy)

  • Paolo Perrini

    (Department of Neurosurgery, Azienda Ospedaliera Universitaria Pisana (AOUP), 56126 Pisa, Italy
    Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, 56126 Pisa, Italy)

  • Biagio Rapone

    (Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70121 Bari, Italy)

Abstract

The relationship between type 2 diabetes mellitus (DM2) and hyperglycemia with cancer patients remains controversial also in the setting of patients with glioblastoma multiforme (GBM), the most common and aggressive form of astrocytoma with a short overall survival (OS) and poor prognosis. A systematic search of two databases was performed for studies published up to 19 August 2020, reporting the OS of patients with DM2 or high blood sugar level and GBM and the clinical risk of diabetic patients for development of GBM. According to PRISMA guidelines, we included a total of 20 papers reporting clinical data of patients with GBM and diabetes and/or hyperglycemia. The aim of this review was to investigate the effect of DM2, hyperglycemia and metformin on OS of patients with GBM. In addition, we evaluated the effect of these factors on the risk of development of GBM. This review supports accumulating evidence that hyperglycemia, rather than DM2, and elevated BMI are independent risk factors for poor outcome and shorter OS in patients with GBM. GBM patients with normal weight compared to obese, and diabetic patients on metformin compared to other therapies, seems to have a longer OS. Further studies are needed to understand better these associations.

Suggested Citation

  • Nicola Montemurro & Paolo Perrini & Biagio Rapone, 2020. "Clinical Risk and Overall Survival in Patients with Diabetes Mellitus, Hyperglycemia and Glioblastoma Multiforme. A Review of the Current Literature," IJERPH, MDPI, vol. 17(22), pages 1-18, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:22:p:8501-:d:446110
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    Cited by:

    1. Biagio Rapone & Elisabetta Ferrara & Massimo Corsalini & Erda Qorri & Ilaria Converti & Felice Lorusso & Maurizio Delvecchio & Antonio Gnoni & Salvatore Scacco & Antonio Scarano, 2021. "Inflammatory Status and Glycemic Control Level of Patients with Type 2 Diabetes and Periodontitis: A Randomized Clinical Trial," IJERPH, MDPI, vol. 18(6), pages 1-16, March.
    2. Nicola Montemurro & Sara Condino & Nadia Cattari & Renzo D’Amato & Vincenzo Ferrari & Fabrizio Cutolo, 2021. "Augmented Reality-Assisted Craniotomy for Parasagittal and Convexity En Plaque Meningiomas and Custom-Made Cranio-Plasty: A Preliminary Laboratory Report," IJERPH, MDPI, vol. 18(19), pages 1-13, September.
    3. Siyun Sun & Yingyuan Chen & Sen Mu & Bo Jiang & Yiwei Lin & Tian Gao & Ling Qiu, 2021. "The Psychological Restorative Effects of Campus Environments on College Students in the Context of the COVID-19 Pandemic: A Case Study at Northwest A&F University, Shaanxi, China," IJERPH, MDPI, vol. 18(16), pages 1-12, August.
    4. Biagio Rapone & Elisabetta Ferrara & Luigi Santacroce & Skender Topi & Antonio Gnoni & Gianna Dipalma & Antonio Mancini & Marina Di Domenico & Gianluca Martino Tartaglia & Antonio Scarano & Francesco , 2022. "The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial," IJERPH, MDPI, vol. 19(2), pages 1-14, January.

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