IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i6p3018-d517268.html
   My bibliography  Save this article

Inflammatory Status and Glycemic Control Level of Patients with Type 2 Diabetes and Periodontitis: A Randomized Clinical Trial

Author

Listed:
  • Biagio Rapone

    (Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Elisabetta Ferrara

    (Complex Operative Unit of Odontostomatology, Hospital S.S. Annunziata, 66100 Chieti, Italy)

  • Massimo Corsalini

    (Interdisciplinary Department of Medicine, University of Bari, 70121 Bari, Italy)

  • Erda Qorri

    (Dean Faculty of Medical Sciences, Albanian University, Bulevardi Zogu I, 1001 Tirana, Albania)

  • Ilaria Converti

    (Department of Emergency and Organ Transplantation, Division of Plastic and Reconstructive Surgery, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Felice Lorusso

    (Department of Oral Science, Nano and Biotechnology and CeSi-Met University of Chieti-Pescara, 66100 Chieti, Italy)

  • Maurizio Delvecchio

    (Department of Metabolic and Genetic Diseases, Giovanni XXIII Children’s Hospital, 70126 Bari, Italy)

  • Antonio Gnoni

    (Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Salvatore Scacco

    (Department of Basic Medical Sciences, Neurosciences and Sense Organs, “Aldo Moro” University of Bari, 70121 Bari, Italy)

  • Antonio Scarano

    (Department of Oral Science, Nano and Biotechnology and CeSi-Met University of Chieti-Pescara, 66100 Chieti, Italy)

Abstract

Background: Based on the holistic approach to prevention diabetic disease, the role of periodontal inflammation in type 2 diabetes mellitus (T2DM) is under intensive scrutiny. Data from clinical trials have shown benefit from a periodontal therapy in providing patients with type 2 diabetes improvement despite relatively disappointing long-terms response rates. The aim of this study was to investigate the short-term glycemic control level and systemic inflammatory status after periodontal therapy. Methods: This was a randomized trial with a 6-months follow-up. Participants aged 56.4 ± 7.9 years with diagnosed type 2 diabetes and periodontitis were enrolled. Among the 187 type 2 diabetic patients, 93 were randomly assigned to receive non-surgical periodontal treatment immediately and 94 to receive the delayed treatment. Within and between groups comparison was done during the study period, and the differences between groups were assessed. Results: The difference between HbA1c values at baseline ( Mdn = 7.7) and 6 months after non-surgical periodontal treatment ( Mdn = 7.2) was statistically significant, U = 3174.5, p = 0.012, r = 0.187. However, although technically a positive correlation, the relationship between the glycated hemoglobin value and periodontal variables was weak. The differences between both the groups over 6 months were not statistically considerable, failing to reach statistical significance. At 6 months the difference between groups about the C-reactive protein (CRP) levels was statistically significant, U =1839.5, p = 0, r = 0.472, with a lower concentration for the intervention group. Furthermore, the intervention group showed a statistically significant difference between baseline and 6 months evaluation ( U = 2606.5, p = 0, r = 0.308). Conclusions: The periodontal intervention potentially may allow individuals with type 2 diabetes to improve glycemic control and CRP concentrations, and diabetes alters the periodontal status.

Suggested Citation

  • Biagio Rapone & Elisabetta Ferrara & Massimo Corsalini & Erda Qorri & Ilaria Converti & Felice Lorusso & Maurizio Delvecchio & Antonio Gnoni & Salvatore Scacco & Antonio Scarano, 2021. "Inflammatory Status and Glycemic Control Level of Patients with Type 2 Diabetes and Periodontitis: A Randomized Clinical Trial," IJERPH, MDPI, vol. 18(6), pages 1-16, March.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:3018-:d:517268
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/6/3018/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/6/3018/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Nicola Montemurro & Paolo Perrini & Biagio Rapone, 2020. "Clinical Risk and Overall Survival in Patients with Diabetes Mellitus, Hyperglycemia and Glioblastoma Multiforme. A Review of the Current Literature," IJERPH, MDPI, vol. 17(22), pages 1-18, November.
    2. Biagio Rapone & Elisabetta Ferrara & Luigi Santacroce & Skender Topi & Ilaria Converti & Antonio Gnoni & Antonio Scarano & Salvatore Scacco, 2020. "Gingival Crevicular Blood as a Potential Screening Tool: A Cross Sectional Comparative Study," IJERPH, MDPI, vol. 17(20), pages 1-8, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nicola Montemurro & Sara Condino & Nadia Cattari & Renzo D’Amato & Vincenzo Ferrari & Fabrizio Cutolo, 2021. "Augmented Reality-Assisted Craniotomy for Parasagittal and Convexity En Plaque Meningiomas and Custom-Made Cranio-Plasty: A Preliminary Laboratory Report," IJERPH, MDPI, vol. 18(19), pages 1-13, September.
    2. Siyun Sun & Yingyuan Chen & Sen Mu & Bo Jiang & Yiwei Lin & Tian Gao & Ling Qiu, 2021. "The Psychological Restorative Effects of Campus Environments on College Students in the Context of the COVID-19 Pandemic: A Case Study at Northwest A&F University, Shaanxi, China," IJERPH, MDPI, vol. 18(16), pages 1-12, August.
    3. Biagio Rapone & Elisabetta Ferrara & Luigi Santacroce & Skender Topi & Antonio Gnoni & Gianna Dipalma & Antonio Mancini & Marina Di Domenico & Gianluca Martino Tartaglia & Antonio Scarano & Francesco , 2022. "The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial," IJERPH, MDPI, vol. 19(2), pages 1-14, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:3018-:d:517268. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.