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Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study

Author

Listed:
  • Natalia Landeros

    (Centro Oncológico, Facultad de Medicina, Universidad de Católica del Maule, Talca 3466706, Chile
    Laboratorio de Investigaciones Biomédicas (LIB), Facultad de Medicina, Universidad de Católica del Maule, Talca 3466706, Chile)

  • Soledad Duk

    (Laboratorio de Citogenética y Genética Toxicológica, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile)

  • Carolina Márquez

    (Laboratorio de Citogenética y Genética Toxicológica, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile)

  • Bárbara Inzunza

    (Laboratorio de Citogenética y Genética Toxicológica, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4070386, Chile)

  • Ian S. Acuña-Rodríguez

    (Instituto de Investigaciones Interdisciplinarias (I 3 ), Universidad de Talca, Talca 3465548, Chile)

  • Liliana A. Zúñiga-Venegas

    (Laboratorio de Investigaciones Biomédicas (LIB), Facultad de Medicina, Universidad de Católica del Maule, Talca 3466706, Chile
    Centro de Investigación de Estudios Avanzados del Maule (CIEAM), Universidad Católica del Maule, Talca 3466706, Chile)

Abstract

Significant risks to human health have been associated with chronic exposure to low doses of pesticides, a situation which may be frequent among agricultural workers. In this context, and regarding the agricultural-based economy of central Chile, we aimed to explore the genotoxic damage in agricultural workers and reproductive risk among women in rural and urban areas of Curicó, a traditional agricultural district in Chile. Hence, we sampled a group of rural agricultural workers associated with pesticide management ( n = 30) and an urban unexposed group ( n = 30). Our results showed that the agricultural workers had higher micronuclei frequencies (MN: β = 13.27; 95% CI low = 11.08, CI high = 15.47) and women had a 40-fold higher risk of reproductive problems (OR = 40.32; 95% CI low = 2.60, CI high = 624.31) than the unexposed group. The factor analysis of mixed data (FAMD) showed that neither the sex nor smoking habits appear to define the ordination of the data. Nevertheless, the exposure level did segregate them in the multidimensional space (explained variance: 35.38% dim-1; 18.63% dim-2). This pilot study highlights the higher risks of biological conditions negatively associated with the health of agricultural workers.

Suggested Citation

  • Natalia Landeros & Soledad Duk & Carolina Márquez & Bárbara Inzunza & Ian S. Acuña-Rodríguez & Liliana A. Zúñiga-Venegas, 2022. "Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study," IJERPH, MDPI, vol. 19(24), pages 1-12, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:24:p:16608-:d:999585
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    References listed on IDEAS

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    2. Brender, J.D. & Maantay, J.A. & Chakraborty, J., 2011. "Residential proximity to environmental hazards and adverse health outcomes," American Journal of Public Health, American Public Health Association, vol. 101(SUPPL. 1), pages 37-52.
    3. Aleksandra Fucic & Radu C. Duca & Karen S. Galea & Tihana Maric & Kelly Garcia & Michael S. Bloom & Helle R. Andersen & John E. Vena, 2021. "Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides," IJERPH, MDPI, vol. 18(12), pages 1-29, June.
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