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Wildfire Smoke Exposure during Pregnancy: A Review of Potential Mechanisms of Placental Toxicity, Impact on Obstetric Outcomes, and Strategies to Reduce Exposure

Author

Listed:
  • Emilia Basilio

    (Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA 94143, USA)

  • Rebecca Chen

    (Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA 94143, USA)

  • Anna Claire Fernandez

    (School of Public Health, University of California, Berkeley, CA 94704, USA)

  • Amy M. Padula

    (Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA 94143, USA
    These authors contributed equally to this work.)

  • Joshua F. Robinson

    (Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA 94143, USA
    These authors contributed equally to this work.)

  • Stephanie L. Gaw

    (Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA 94143, USA
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA 94143, USA
    These authors contributed equally to this work.)

Abstract

Climate change is accelerating the intensity and frequency of wildfires globally. Understanding how wildfire smoke (WS) may lead to adverse pregnancy outcomes and alterations in placental function via biological mechanisms is critical to mitigate the harms of exposure. We aim to review the literature surrounding WS, placental biology, biological mechanisms underlying adverse pregnancy outcomes as well as interventions and strategies to avoid WS exposure in pregnancy. This review includes epidemiologic and experimental laboratory-based studies of WS, air pollution, particulate matter (PM), and other chemicals related to combustion in relation to obstetric outcomes and placental biology. We summarized the available clinical, animal, and placental studies with WS and other combustion products such as tobacco, diesel, and wood smoke. Additionally, we reviewed current recommendations for prevention of WS exposure. We found that there is limited data specific to WS; however, studies on air pollution and other combustion sources suggest a link to inflammation, oxidative stress, endocrine disruption, DNA damage, telomere shortening, epigenetic changes, as well as metabolic, vascular, and endothelial dysregulation in the maternal-fetal unit. These alterations in placental biology contribute to adverse obstetric outcomes that disproportionally affect the most vulnerable. Limiting time outdoors, wearing N95 respirator face masks and using high quality indoor air filters during wildfire events reduces exposure to related environmental exposures and may mitigate morbidities attributable to WS.

Suggested Citation

  • Emilia Basilio & Rebecca Chen & Anna Claire Fernandez & Amy M. Padula & Joshua F. Robinson & Stephanie L. Gaw, 2022. "Wildfire Smoke Exposure during Pregnancy: A Review of Potential Mechanisms of Placental Toxicity, Impact on Obstetric Outcomes, and Strategies to Reduce Exposure," IJERPH, MDPI, vol. 19(21), pages 1-29, October.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:13727-:d:950365
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    References listed on IDEAS

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    1. Jia Coco Liu & Loretta J. Mickley & Melissa P. Sulprizio & Francesca Dominici & Xu Yue & Keita Ebisu & Georgiana Brooke Anderson & Rafi F. A. Khan & Mercedes A. Bravo & Michelle L. Bell, 2016. "Particulate air pollution from wildfires in the Western US under climate change," Climatic Change, Springer, vol. 138(3), pages 655-666, October.
    2. Sandie Ha & Carrie Nobles & Jenna Kanner & Seth Sherman & Seung-Hyun Cho & Neil Perkins & Andrew Williams & William Grobman & Joseph Biggio & Akila Subramaniam & Marion Ouidir & Zhen Chen & Pauline Me, 2020. "Air Pollution Exposure Monitoring among Pregnant Women with and without Asthma," IJERPH, MDPI, vol. 17(13), pages 1-16, July.
    3. Shawn J. Mccoy & Xiaoxi Zhao, 2021. "Wildfire and infant health: a geospatial approach to estimating the health impacts of wildfire smoke exposure," Applied Economics Letters, Taylor & Francis Journals, vol. 28(1), pages 32-37, January.
    4. Seema Jayachandran, 2009. "Air Quality and Early-Life Mortality: Evidence from Indonesia’s Wildfires," Journal of Human Resources, University of Wisconsin Press, vol. 44(4).
    5. John P. Capitanio & Laura A. Rosso & Nancy Gee & Bill L. Lasley, 2022. "Adverse biobehavioral effects in infants resulting from pregnant rhesus macaques’ exposure to wildfire smoke," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    6. Ergün Sahin & Simona Colla & Marc Liesa & Javid Moslehi & Florian L. Müller & Mira Guo & Marcus Cooper & Darrell Kotton & Attila J. Fabian & Carl Walkey & Richard S. Maser & Giovanni Tonon & Friedrich, 2011. "Telomere dysfunction induces metabolic and mitochondrial compromise," Nature, Nature, vol. 470(7334), pages 359-365, February.
    7. Ergün Sahin & Simona Colla & Marc Liesa & Javid Moslehi & Florian L. Müller & Mira Guo & Marcus Cooper & Darrell Kotton & Attila J. Fabian & Carl Walkey & Richard S. Maser & Giovanni Tonon & Friedrich, 2011. "Erratum: Telomere dysfunction induces metabolic and mitochondrial compromise," Nature, Nature, vol. 475(7355), pages 254-254, July.
    8. Mona Abdo & Isabella Ward & Katelyn O’Dell & Bonne Ford & Jeffrey R. Pierce & Emily V. Fischer & James L. Crooks, 2019. "Impact of Wildfire Smoke on Adverse Pregnancy Outcomes in Colorado, 2007–2015," IJERPH, MDPI, vol. 16(19), pages 1-16, October.
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