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Adverse biobehavioral effects in infants resulting from pregnant rhesus macaques’ exposure to wildfire smoke

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  • John P. Capitanio

    (University of California
    University of California)

  • Laura A. Rosso

    (University of California)

  • Nancy Gee

    (University of California)

  • Bill L. Lasley

    (University of California)

Abstract

As wildfires across the world increase in number, size, and intensity, exposure to wildfire smoke (WFS) is a growing health problem. To date, however, little is known for any species on what might be the behavioral or physiological consequences of prenatal exposure to WFS. Here we show that infant rhesus monkeys exposed to WFS in the first third of gestation (n = 52) from the Camp Fire (California, November, 2018) show greater inflammation, blunted cortisol, more passive behavior, and memory impairment compared to animals conceived after smoke had dissipated (n = 37). Parallel analyses, performed on a historical control cohort (n = 2490), did not support the alternative hypothesis that conception timing alone could explain the results. We conclude that WFS may have a teratogenic effect on the developing fetus and speculate on mechanisms by which WFS might affect neural development.

Suggested Citation

  • John P. Capitanio & Laura A. Rosso & Nancy Gee & Bill L. Lasley, 2022. "Adverse biobehavioral effects in infants resulting from pregnant rhesus macaques’ exposure to wildfire smoke," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29436-9
    DOI: 10.1038/s41467-022-29436-9
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    Cited by:

    1. Emilia Basilio & Rebecca Chen & Anna Claire Fernandez & Amy M. Padula & Joshua F. Robinson & Stephanie L. Gaw, 2022. "Wildfire Smoke Exposure during Pregnancy: A Review of Potential Mechanisms of Placental Toxicity, Impact on Obstetric Outcomes, and Strategies to Reduce Exposure," IJERPH, MDPI, vol. 19(21), pages 1-29, October.

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