IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i15p9469-d878276.html
   My bibliography  Save this article

Proof of Concept of a 6-Month Person-Oriented Exercise Intervention ‘MultiPill-Exercise’ among Patients at Risk of or with Multiple Chronic Diseases: Results of a One-Group Pilot Trial

Author

Listed:
  • Simone Schweda

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

  • Barbara Munz

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

  • Christof Burgstahler

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

  • Andreas Michael Niess

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

  • Inka Roesel

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany
    Institute for Clinical Epidemiology and Applied Biostatistics, University of Tuebingen, 72074 Tuebingen, Germany)

  • Gorden Sudeck

    (Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany
    Institute of Sports Science, Eberhard Karls University, 72076 Tuebingen, Germany)

  • Inga Krauss

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

Abstract

Physical exercise has been shown to be effective in the treatment of non-communicable chronic diseases. However, patients with multiple chronic diseases (multimorbidity) have received little attention in health policy. This pilot trial served as a proof of concept of a 6-months person-oriented exercise intervention for people at risk of or with diagnosed cardiovascular diseases, diabetes mellitus type 2, overweight and/or hip/knee osteoarthritis, regarding effects on health outcomes as well as adherence and safety. The intervention (‘MultiPill-Exercise’) was designed to promote physical exercise participation, considering an individual perspective by addressing personal and environmental factors. Outcomes were assessed at baseline (t0) and after three- (t3) and six-months (t6). The primary outcome was self-reported physical exercise participation in minutes/week comparing t3 and t6 vs. t0. Secondary outcomes included cardio-respiratory fitness (maximum oxygen uptake VO 2 peak during incremental cycling ergometry), isometric peak torque of knee extensors and flexors, health-related quality of life (Veterans Rand 12 with its subscales of perceived general health (GH), mental health (MCS), and physical health (PCS)) and blood levels. Adherence to exercise (% of attended sessions during the first 12-weeks of the intervention) and adverse events were monitored as well. Data were analyzed using a non-parametric procedure for longitudinal data, estimating rank means (M Rank ) and relative treatment effects (RTE) as well as linear-mixed effect models for parametric data. The primary endpoint of physical exercise participation was significantly higher at t3 and t6 compared to baseline (t3 vs. t0: M Rank = 77.1, p < 0.001, RTE: 0.66; t6 vs. t0: M Rank = 70.6, p < 0.001, RTE = 0.60). Improvements at both follow-up time points compared to t0 were also found for relative VO 2 peak (t3 vs. t0 = 2.6 mL/kg/min, p < 0.001; t6 vs. t0 = 2.0 mL/kg/min, p = 0.001), strength of knee extensors (t3 vs. t0 = 11.7 Nm, p = 0.007; t6 vs. t0= 18.1 Nm, p < 0.001) and GH (t3 vs. t0 = 16.2, p = 0.003; t6 vs. t0 = 13.4, p = 0.008). No changes were found for MCS, PCS and for blood levels. Overall exercise adherence was 77%. No serious adverse events were recorded. Results of this pilot trial represent a first proof of concept for the intervention ‘MultiPill-Exercise’ that will now be implemented and evaluated in a real-world health care setting.

Suggested Citation

  • Simone Schweda & Barbara Munz & Christof Burgstahler & Andreas Michael Niess & Inka Roesel & Gorden Sudeck & Inga Krauss, 2022. "Proof of Concept of a 6-Month Person-Oriented Exercise Intervention ‘MultiPill-Exercise’ among Patients at Risk of or with Multiple Chronic Diseases: Results of a One-Group Pilot Trial," IJERPH, MDPI, vol. 19(15), pages 1-24, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9469-:d:878276
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/15/9469/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/15/9469/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Yi-Pang Lo & Shang-Lin Chiang & Chia-Huei Lin & Hung-Chang Liu & Li-Chi Chiang, 2020. "Effects of Individualized Aerobic Exercise Training on Physical Activity and Health-Related Physical Fitness among Middle-Aged and Older Adults with Multimorbidity: A Randomized Controlled Trial," IJERPH, MDPI, vol. 18(1), pages 1-16, December.
    2. Rijken, Mieke & Hujala, Anneli & van Ginneken, Ewout & Melchiorre, Maria Gabriella & Groenewegen, Peter & Schellevis, Franζois, 2018. "Managing multimorbidity: Profiles of integrated care approaches targeting people with multiple chronic conditions in Europe," Health Policy, Elsevier, vol. 122(1), pages 44-52.
    3. Vedrana Sember & Kaja Meh & Maroje Sorić & Gregor Starc & Paulo Rocha & Gregor Jurak, 2020. "Validity and Reliability of International Physical Activity Questionnaires for Adults across EU Countries: Systematic Review and Meta Analysis," IJERPH, MDPI, vol. 17(19), pages 1-23, September.
    4. Julia Schmid & Vanessa Gut & Achim Conzelmann & Gorden Sudeck, 2018. "Bernese motive and goal inventory in exercise and sport: Validation of an updated version of the questionnaire," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-13, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ayazullah Safi & Irfan Khawaja & Peter Collins & Tony Myers, 2023. "A Cross-Sectional Study Exploring the Physical Activity Levels of Afghans and Other South Asian Youth in the UK," IJERPH, MDPI, vol. 20(2), pages 1-11, January.
    2. Csanádi, Marcell & Kaló, Zoltán & Rutten-van Molken, Maureen & Looman, Willemijn & Huic, Mirjana & Ercevic, Darija & Atanasijevic, Dragana & Lorenzovici, László & Petryszyn, Paweł & Pogány, Gábor & Pi, 2022. "Prioritization of implementation barriers related to integrated care models in Central and Eastern European countries," Health Policy, Elsevier, vol. 126(11), pages 1173-1179.
    3. Marcus Vinicius Nascimento-Ferreira & Ana Clara Arrais Rosa & Jacyara Cristina Azevedo & Armando Rodrigues de Alencar Santos & Keisyanne De Araujo-Moura & Kelber Abrão Ferreira, 2022. "Psychometric Properties of the Online International Physical Activity Questionnaire in College Students," IJERPH, MDPI, vol. 19(22), pages 1-9, November.
    4. Thomas Ernst Dorner & Christian Lackinger & Sandra Haider & Igor Grabovac & Katharina Viktoria Stein, 2021. "The Influence of Occupational Categories on Overall and Domain-Specific Physical Activity and the Association with Chronic Diseases. An Analysis Using the Austrian Health Interview Survey," IJERPH, MDPI, vol. 18(4), pages 1-16, February.
    5. Dinko Martinovic & Daria Tokic & Marino Vilovic & Doris Rusic & Josipa Bukic & Josko Bozic, 2021. "Sport Dietary Supplements and Physical Activity in Biomedical Students," IJERPH, MDPI, vol. 18(4), pages 1-14, February.
    6. Ahmed Tarek Zaky Fouad & Danielle Sinnett & Isabelle Bray & Rachael McClatchey & Rebecca Reece, 2023. "Measures of Greenspace Exposure and Their Association to Health-Related Outcomes for the Periods before and during the 2020 Lockdown: A Cross-Sectional Study in the West of England," Land, MDPI, vol. 12(4), pages 1-18, March.
    7. Zisis Papazisis & Pantelis T. Nikolaidis & Georgia Trakada, 2021. "Sleep, Physical Activity, and Diet of Adults during the Second Lockdown of the COVID-19 Pandemic in Greece," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    8. Jorge Velázquez Saornil & Zacarías Sánchez Milá & Angélica M. Campón Chekroun & Luis Baraja Vegas & Juan Vicente Mampel & Raúl Frutos Llanes & José Manuel Barragán Casas & David Rodríguez-Sanz, 2022. "Comparative Study of the Efficacy of Hyaluronic Acid, Dry Needling and Combined Treatment in Patellar Osteoarthritis—Single-Blind Randomized Clinical Trial," IJERPH, MDPI, vol. 19(17), pages 1-15, September.
    9. Maria Gabriella Melchiorre & Giovanni Lamura & Francesco Barbabella & on behalf of ICARE4EU Consortium, 2018. "eHealth for people with multimorbidity: Results from the ICARE4EU project and insights from the “10 e’s” by Gunther Eysenbach," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-26, November.
    10. Olaia Eizagirre-Sagastibeltza & Uxue Fernandez-Lasa & Javier Yanci & Estibaliz Romaratezabala & Ruth Cayero & Iñaki Iturrioz & Oidui Usabiaga, 2022. "Design and Validation of a Questionnaire to Assess the Leisure Time Physical Activity of Adult Women in Gipuzkoa," IJERPH, MDPI, vol. 19(9), pages 1-18, May.
    11. Kele Ding & Jingzhen Yang & Ming-Kai Chin & Lindsay Sullivan & J. Larry Durstine & Verónica Violant-Holz & Giyasettin Demirhan & Nara R.C. Oliveira & Biljana Popeska & Garry Kuan & Waheeda Khan & Jian, 2021. "Physical Activity among Adults Residing in 11 Countries during the COVID-19 Pandemic Lockdown," IJERPH, MDPI, vol. 18(13), pages 1-16, July.
    12. Vojko Vučković & Klemen Krejač & Tanja Kajtna, 2022. "Exercise Motives of College Students after the COVID-19 Lockdown," IJERPH, MDPI, vol. 19(12), pages 1-11, June.
    13. Julia Schmid & Vanessa Gut & Nina Schorno & Takuya Yanagida & Achim Conzelmann, 2021. "Within-Person Variation of Affective Well-Being during and after Exercise: Does the Person–Exercise Fit Matter?," IJERPH, MDPI, vol. 18(2), pages 1-8, January.
    14. Hui Gao & Xingxing Li & Yunhua Zi & Xuanwen Mu & Mingjian Fu & Tingting Mo & Kuai Yu, 2022. "Reliability and Validity of Common Subjective Instruments in Assessing Physical Activity and Sedentary Behaviour in Chinese College Students," IJERPH, MDPI, vol. 19(14), pages 1-10, July.
    15. Pauliina Husu & Henri Vähä-Ypyä & Kari Tokola & Harri Sievänen & Paulo Rocha & Tommi Vasankari, 2024. "Reliability and Validity of Self-Reported Questionnaires Assessing Physical Activity and Sedentary Behavior in Finland," IJERPH, MDPI, vol. 21(6), pages 1-13, May.
    16. Looman, Willemijn & Struckmann, Verena & Köppen, Julia & Baltaxe, Erik & Czypionka, Thomas & Huic, Mirjana & Pitter, Janos & Ruths, Sabine & Stokes, Jonathan & Bal, Roland & Rutten-van Mölken, Maureen, 2021. "Drivers of successful implementation of integrated care for multi-morbidity: Mechanisms identified in 17 case studies from 8 European countries," Social Science & Medicine, Elsevier, vol. 277(C).
    17. Kaja Kastelic & Nejc Šarabon & Michael D. Burnard & Željko Pedišić, 2022. "Validity and Reliability of the Daily Activity Behaviours Questionnaire (DABQ) for Assessment of Time Spent in Sleep, Sedentary Behaviour, and Physical Activity," IJERPH, MDPI, vol. 19(9), pages 1-11, April.
    18. Clemens Ley, 2020. "Participation Motives of Sport and Exercise Maintainers: Influences of Age and Gender," IJERPH, MDPI, vol. 17(21), pages 1-13, October.
    19. Antonio Castillo-Paredes & Beatriz Iglésias & Claudio Farías-Valenzuela & Irina Kovalskys & Georgina Gómez & Attilio Rigotti & Lilia Yadira Cortés & Martha Cecilia Yépez García & Rossina G. Pareja & M, 2022. "Perceived Neighborhood Safety and Active Transportation in Adults from Eight Latin American Countries," IJERPH, MDPI, vol. 19(19), pages 1-11, October.
    20. Kaja Meh & Vedrana Sember & Saša Đurić & Henri Vähä-Ypyä & Paulo Rocha & Gregor Jurak, 2021. "Reliability and Validity of Slovenian Versions of IPAQ-SF, GPAQ, and EHIS-PAQ for Assessing Physical Activity and Sedentarism of Adults," IJERPH, MDPI, vol. 19(1), pages 1-15, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9469-:d:878276. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.