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Proof of Concept of a 6-Month Person-Oriented Exercise Intervention ‘MultiPill-Exercise’ among Patients at Risk of or with Multiple Chronic Diseases: Results of a One-Group Pilot Trial

Author

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  • Simone Schweda

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

  • Barbara Munz

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

  • Christof Burgstahler

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

  • Andreas Michael Niess

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

  • Inka Roesel

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany
    Institute for Clinical Epidemiology and Applied Biostatistics, University of Tuebingen, 72074 Tuebingen, Germany)

  • Gorden Sudeck

    (Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany
    Institute of Sports Science, Eberhard Karls University, 72076 Tuebingen, Germany)

  • Inga Krauss

    (Department of Sports Medicine, University Hospital, Medical Clinic, 72074 Tuebingen, Germany
    Interfaculty Research Institute for Sports and Physical Activity, 72074 Tuebingen, Germany)

Abstract

Physical exercise has been shown to be effective in the treatment of non-communicable chronic diseases. However, patients with multiple chronic diseases (multimorbidity) have received little attention in health policy. This pilot trial served as a proof of concept of a 6-months person-oriented exercise intervention for people at risk of or with diagnosed cardiovascular diseases, diabetes mellitus type 2, overweight and/or hip/knee osteoarthritis, regarding effects on health outcomes as well as adherence and safety. The intervention (‘MultiPill-Exercise’) was designed to promote physical exercise participation, considering an individual perspective by addressing personal and environmental factors. Outcomes were assessed at baseline (t0) and after three- (t3) and six-months (t6). The primary outcome was self-reported physical exercise participation in minutes/week comparing t3 and t6 vs. t0. Secondary outcomes included cardio-respiratory fitness (maximum oxygen uptake VO 2 peak during incremental cycling ergometry), isometric peak torque of knee extensors and flexors, health-related quality of life (Veterans Rand 12 with its subscales of perceived general health (GH), mental health (MCS), and physical health (PCS)) and blood levels. Adherence to exercise (% of attended sessions during the first 12-weeks of the intervention) and adverse events were monitored as well. Data were analyzed using a non-parametric procedure for longitudinal data, estimating rank means (M Rank ) and relative treatment effects (RTE) as well as linear-mixed effect models for parametric data. The primary endpoint of physical exercise participation was significantly higher at t3 and t6 compared to baseline (t3 vs. t0: M Rank = 77.1, p < 0.001, RTE: 0.66; t6 vs. t0: M Rank = 70.6, p < 0.001, RTE = 0.60). Improvements at both follow-up time points compared to t0 were also found for relative VO 2 peak (t3 vs. t0 = 2.6 mL/kg/min, p < 0.001; t6 vs. t0 = 2.0 mL/kg/min, p = 0.001), strength of knee extensors (t3 vs. t0 = 11.7 Nm, p = 0.007; t6 vs. t0= 18.1 Nm, p < 0.001) and GH (t3 vs. t0 = 16.2, p = 0.003; t6 vs. t0 = 13.4, p = 0.008). No changes were found for MCS, PCS and for blood levels. Overall exercise adherence was 77%. No serious adverse events were recorded. Results of this pilot trial represent a first proof of concept for the intervention ‘MultiPill-Exercise’ that will now be implemented and evaluated in a real-world health care setting.

Suggested Citation

  • Simone Schweda & Barbara Munz & Christof Burgstahler & Andreas Michael Niess & Inka Roesel & Gorden Sudeck & Inga Krauss, 2022. "Proof of Concept of a 6-Month Person-Oriented Exercise Intervention ‘MultiPill-Exercise’ among Patients at Risk of or with Multiple Chronic Diseases: Results of a One-Group Pilot Trial," IJERPH, MDPI, vol. 19(15), pages 1-24, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9469-:d:878276
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    References listed on IDEAS

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