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Impact of Environmental Airborne Manganese Exposure on Cognitive and Motor Functions in Adults: A Systematic Review and Meta-Analysis

Author

Listed:
  • Laura Ruiz-Azcona

    (Global Health Research Group, Dpto Enfermería, Universidad de Cantabria, Avda. Valdecilla s/n, 39008 Santander, Cantabria, Spain)

  • Ignacio Fernández-Olmo

    (Dpto. de Ingenierías Química y Biomolecular, Universidad de Cantabria, Avda. Los Castros s/n, 39005 Santander, Cantabria, Spain)

  • Andrea Expósito

    (Dpto. de Ingenierías Química y Biomolecular, Universidad de Cantabria, Avda. Los Castros s/n, 39005 Santander, Cantabria, Spain)

  • Bohdana Markiv

    (Dpto. de Ingenierías Química y Biomolecular, Universidad de Cantabria, Avda. Los Castros s/n, 39005 Santander, Cantabria, Spain)

  • María Paz-Zulueta

    (Economía de la Salud y Gestión de Servicios Sanitarios Research Group, Dpto Enfermería, Universidad de Cantabria, Avda. Valdecilla s/n, 39008 Santander, Cantabria, Spain
    Research Health and Bioethics Law Group, GRIDES, IDIVAL, Calle Cardenal Herrera Oria s/n, 39011 Santander, Cantabria, Spain)

  • Paula Parás-Bravo

    (Economía de la Salud y Gestión de Servicios Sanitarios Research Group, Dpto Enfermería, Universidad de Cantabria, Avda. Valdecilla s/n, 39008 Santander, Cantabria, Spain
    Cuidados Research Group, Dpto Enfermería, Universidad de Cantabria, Avda. Valdecilla s/n, 39008 Santander, Cantabria, Spain)

  • Carmen Sarabia-Cobo

    (Cuidados Research Group, Dpto Enfermería, Universidad de Cantabria, Avda. Valdecilla s/n, 39008 Santander, Cantabria, Spain
    Research Nursing Group, IDIVAL, Calle Cardenal Herrera Oria s/n, 39011 Santander, Cantabria, Spain)

  • Miguel Santibáñez

    (Global Health Research Group, Dpto Enfermería, Universidad de Cantabria, Avda. Valdecilla s/n, 39008 Santander, Cantabria, Spain
    Research Nursing Group, IDIVAL, Calle Cardenal Herrera Oria s/n, 39011 Santander, Cantabria, Spain)

Abstract

Background/Objective: Whether environmental exposure to Manganese (Mn) in adults is associated with poorer results in cognitive and motor function is unclear. We aimed to determine these associations through a meta-analysis of published studies. Methods: A systematic review was conducted to identify epidemiological studies on a population ≥18 years old exposed to environmental airborne Mn, and in which results on specific tests to evaluate cognitive or motor functions were reported. We consulted Medline through PubMed, Web of Science and SCOPUS databases. We also performed a manual search within the list of bibliographic references of the retrieved studies and systematic reviews. To weight Mn effects, a random effects versus fixed effect model was chosen after studying the heterogeneity of each outcome. Results. Eighteen studies met the inclusion criteria. Among them, eleven studies reported data susceptible for meta-analysis through a pooled correlation or a standardized means difference (SMD) approach between exposed and non-exposed groups. Regarding cognitive function, the results of the studies showed heterogeneity among them (I 2 = 76.49%, p < 0.001). The overall effect was a statistically significant negative correlation in the random effects model (pooled r = −0.165; 95%CI: −0.214 to −0.116; p < 0.001). For SMD, the results showed a lower heterogeneity with a negative SMD that did not reach statistical significance under the fixed effects model (SMD = −0.052; 95%CI −0.108 to 0.004; p = 0.068). Regarding motor function, heterogeneity (I 2 = 75%) was also observed in the correlation approach with a pooled r (random effect model) = −0.150; 95%CI: −0.219 to −0.079; p < 0.001. Moderate heterogeneity was observed according to the SMD approach (I 2 = 52.28%), with a pooled SMD = −0.136; 95%CI: −0.188 to−0.084; p < 0.001, indicating worse motor function in those exposed. Conclusions: Correlation approach results support a negative effect on cognitive and motor functions (the higher the Mn levels, the poorer the scores). Regarding the SMD approach, results also support a worse cognitive and motor functions in those exposed, although only for motor function statistical significance was obtained.

Suggested Citation

  • Laura Ruiz-Azcona & Ignacio Fernández-Olmo & Andrea Expósito & Bohdana Markiv & María Paz-Zulueta & Paula Parás-Bravo & Carmen Sarabia-Cobo & Miguel Santibáñez, 2021. "Impact of Environmental Airborne Manganese Exposure on Cognitive and Motor Functions in Adults: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(8), pages 1-30, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:8:p:4075-:d:534892
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    References listed on IDEAS

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    2. Luisa Collado-Garrido & Paula Parás-Bravo & Pilar Calvo-Martín & Miguel Santibáñez-Margüello, 2019. "Impact of Resistance Therapy on Motor Function in Children with Cerebral Palsy: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 16(22), pages 1-21, November.
    3. Carlos Hernández-Jiménez & Raquel Sarabia & María Paz-Zulueta & Paula Paras-Bravo & Amada Pellico & Laura Ruiz Azcona & Cristina Blanco & María Madrazo & María Jesus Agudo & Carmen Sarabia & Miguel Sa, 2019. "Impact of Active Video Games on Body Mass Index in Children and Adolescents: Systematic Review and Meta-Analysis Evaluating the Quality of Primary Studies," IJERPH, MDPI, vol. 16(13), pages 1-37, July.
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    1. Setlamorago Jackson Mbazima & Masilu Daniel Masekameni & Gill Nelson, 2021. "Physicochemical Properties of Indoor and Outdoor Particulate Matter 2.5 in Selected Residential Areas near a Ferromanganese Smelter," IJERPH, MDPI, vol. 18(17), pages 1-18, August.

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