IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i21p8031-d438140.html
   My bibliography  Save this article

Pediatrics Consequences of Caesarean Section—A Systematic Review and Meta-Analysis

Author

Listed:
  • Aneta Słabuszewska-Jóźwiak

    (First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Żelazna 90 Street, 01-004 Warsaw, Poland)

  • Jacek Krzysztof Szymański

    (First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Żelazna 90 Street, 01-004 Warsaw, Poland)

  • Michał Ciebiera

    (Second Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Cegłowska 80 Street, 01-809 Warsaw, Poland)

  • Beata Sarecka-Hujar

    (Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Kasztanowa 3 Street, 41-200 Sosnowiec, Poland)

  • Grzegorz Jakiel

    (First Department of Obstetrics and Gynaecology, Centre of Postgraduate Medical Education, Żelazna 90 Street, 01-004 Warsaw, Poland)

Abstract

Background: Cesarean section is a surgical procedure, which is the most frequently performed in gynecology and obstetrics. It is commonly believed that an operative delivery is a less painful and safer mode of delivery, which translates into an increasing number of the procedures performed without medical indications. The maternal sequelae of cesarean sections are well elucidated and widely discussed in the literature, while long-term neonatal consequences still remain the issue of research and scientific dispute. The aim of the present paper was to perform a systematic review of current literature regarding pediatrics consequences of cesarean section. Methods: We reviewed available data from PubMed, Science Direct as well as Google Scholar bases concerning early and long-term neonatal sequelae of operative deliveries. The following key words were used: “cesarean section”, “caesarean section”, “neonatal outcomes”, “respiratory disorders”, “asthma”, “obesity”, “overweight”, and “neurological disorders”. A total of 1636 papers were retrieved out of which 27 were selected for the final systematic review whereas 16 articles provided data for meta-analysis. Statistical analyses were performed using RevMan 5.4. To determine the strength of association between the caesarean section and respiratory tract infections, asthma, diabetes type 1 as well as obesity the pooled odds ratios (OR) with the 95% confidence intervals (CI) were calculated. Results: Conducted meta-analyses revealed that caesarean section is a risk factor for respiratory tract infections (pooled OR = 1.30 95%CI 1.06–1.60, p = 0.001), asthma (pooled OR = 1.23 95%CI 1.14–1.33, p < 0.00001) as well as obesity (pooled OR = 1.35 95%CI 1.29–1.41, p < 0.00001) in offspring. Conclusions: The results of the studies included indicated that children delivered by cesarean section more commonly developed respiratory tract infections, obesity and the manifestations of asthma than children delivered vaginally. The risk of developing diabetes mellitus type 1 or neurological disorders in offspring after caesarean section is still under discussion.

Suggested Citation

  • Aneta Słabuszewska-Jóźwiak & Jacek Krzysztof Szymański & Michał Ciebiera & Beata Sarecka-Hujar & Grzegorz Jakiel, 2020. "Pediatrics Consequences of Caesarean Section—A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(21), pages 1-17, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:8031-:d:438140
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/21/8031/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/21/8031/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Oonagh E Keag & Jane E Norman & Sarah J Stock, 2018. "Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis," PLOS Medicine, Public Library of Science, vol. 15(1), pages 1-22, January.
    2. Aneta Słabuszewska-Jóżwiak & Marta Włodarczyk & Krzysztof Kilian & Zbigniew Rogulski & Michał Ciebiera & Jolanta Szymańska-Majchrzak & Kornelia Zaręba & Jacek Krzysztof Szymański & Dorota Raczkiewicz , 2020. "Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?," IJERPH, MDPI, vol. 17(15), pages 1-13, August.
    3. Gwinyai Masukume & Ali S Khashan & Susan M B Morton & Philip N Baker & Louise C Kenny & Fergus P McCarthy, 2019. "Caesarean section delivery and childhood obesity in a British longitudinal cohort study," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-13, October.
    4. Yan Shao & Samuel C. Forster & Evdokia Tsaliki & Kevin Vervier & Angela Strang & Nandi Simpson & Nitin Kumar & Mark D. Stares & Alison Rodger & Peter Brocklehurst & Nigel Field & Trevor D. Lawley, 2019. "Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth," Nature, Nature, vol. 574(7776), pages 117-121, October.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sonia Lippke & Christina Derksen & Franziska Maria Keller & Lukas Kötting & Martina Schmiedhofer & Annalena Welp, 2021. "Effectiveness of Communication Interventions in Obstetrics—A Systematic Review," IJERPH, MDPI, vol. 18(5), pages 1-27, March.
    2. Doan Thi Thuy Duong & Colin Binns & Andy Lee & Yun Zhao & Ngoc Minh Pham & Dinh Thi Phuong Hoa & Bui Thi Thu Ha, 2022. "Intention to Exclusively Breastfeed Is Associated with Lower Rates of Cesarean Section for Nonmedical Reasons in a Cohort of Mothers in Vietnam," IJERPH, MDPI, vol. 19(2), pages 1-11, January.
    3. Martina Schmiedhofer & Christina Derksen & Johanna Elisa Dietl & Freya Haeussler & Reinhard Strametz & Beate Huener & Sonia Lippke, 2022. "The Impact of a Communication Training on the Birth Experience: Qualitative Interviews with Mothers after Giving Birth at Obstetric University Departments in Germany," IJERPH, MDPI, vol. 19(18), pages 1-17, September.
    4. Jacek K. Szymański & Aneta Słabuszewska-Jóźwiak & Grzegorz Jakiel, 2021. "Vaginal Aging—What We Know and What We Do Not Know," IJERPH, MDPI, vol. 18(9), pages 1-10, May.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Shuqin Zeng & Dhrati Patangia & Alexandre Almeida & Zhemin Zhou & Dezhi Mu & R. Paul Ross & Catherine Stanton & Shaopu Wang, 2022. "A compendium of 32,277 metagenome-assembled genomes and over 80 million genes from the early-life human gut microbiome," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Bin Zhu & David J. Edwards & Katherine M. Spaine & Laahirie Edupuganti & Andrey Matveyev & Myrna G. Serrano & Gregory A. Buck, 2024. "The association of maternal factors with the neonatal microbiota and health," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Shelly Jun & Kelsea Drall & Brittany Matenchuk & Cara McLean & Charlene Nielsen & Chinwe V. Obiakor & Aaron Van der Leek & Anita Kozyrskyj, 2018. "Sanitization of Early Life and Microbial Dysbiosis," Challenges, MDPI, vol. 9(2), pages 1-9, December.
    4. Kerstin Thriene & Karin B. Michels, 2023. "Human Gut Microbiota Plasticity throughout the Life Course," IJERPH, MDPI, vol. 20(2), pages 1-14, January.
    5. Taja Bracic & Isabella Pfniß & Nadja Taumberger & Kaltrina Kutllovci-Hasani & Daniela Ulrich & Wolfgang Schöll & Philipp Reif, 2020. "A 10 year comparative study of caesarean deliveries using the Robson 10 group classification system in a university hospital in Austria," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-11, October.
    6. David Card & Alessandra Fenizia & David Silver, 2023. "The Health Impacts of Hospital Delivery Practices," American Economic Journal: Economic Policy, American Economic Association, vol. 15(2), pages 42-81, May.
    7. Justine Tanoey & Christina Baechle & Hermann Brenner & Andreas Deckert & Julia Fricke & Kathrin Günther & André Karch & Thomas Keil & Alexander Kluttig & Michael Leitzmann & Rafael Mikolajczyk & Nadia, 2022. "Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort," IJERPH, MDPI, vol. 19(17), pages 1-14, August.
    8. Brandon Hickman & Anne Salonen & Alise J. Ponsero & Roosa Jokela & Kaija-Leena Kolho & Willem M. Vos & Katri Korpela, 2024. "Gut microbiota wellbeing index predicts overall health in a cohort of 1000 infants," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    9. Maria Nieto-Rosado & Kirsty Sands & Edward A. R. Portal & Kathryn M. Thomson & Maria J. Carvalho & Jordan Mathias & Rebecca Milton & Calie Dyer & Chinenye Akpulu & Ian Boostrom & Patrick Hogan & Habib, 2024. "Colonisation of hospital surfaces from low- and middle-income countries by extended spectrum β-lactamase- and carbapenemase-producing bacteria," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    10. Ana Costa-Ramón & Mika Kortelainen & Ana Rodríguez-González & Lauri Sääksvuori, 2022. "The Long-Run Effects of Cesarean Sections," Journal of Human Resources, University of Wisconsin Press, vol. 57(6), pages 2048-2085.
    11. Gwinyai Masukume & Ali S Khashan & Susan M B Morton & Philip N Baker & Louise C Kenny & Fergus P McCarthy, 2019. "Caesarean section delivery and childhood obesity in a British longitudinal cohort study," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-13, October.
    12. Na Chen & Lilan Hao & Zhe Zhang & Chenglu Qin & Zhuye Jie & Hongxin Pan & Jiali Duan & Xincheng Huang & Yunhong Zhang & Hongqin Gao & Ruike Lu & Tianshu Sun & Hua Yang & Jinqiu Shi & Maolian Liang & J, 2024. "Insights into the assembly of the neovaginal microbiota in Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome patients," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    13. Maria Healy & Viola Nyman & Dale Spence & René H J Otten & Corine J Verhoeven, 2020. "How do midwives facilitate women to give birth during physiological second stage of labour? A systematic review," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-19, July.
    14. Lenore Manderson & Fiona C. Ross, 2020. "Publics, technologies and interventions in reproduction and early life in South Africa," Palgrave Communications, Palgrave Macmillan, vol. 7(1), pages 1-9, December.
    15. Azahara María García-Serna & Elena Martín-Orozco & Trinidad Hernández-Caselles & Eva Morales, 2021. "Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins," IJERPH, MDPI, vol. 18(8), pages 1-24, April.
    16. Rosaria Cappadona & Sara Puzzarini & Vanessa Farinelli & Piergiorgio Iannone & Alfredo De Giorgi & Emanuele Di Simone & Roberto Manfredini & Rosita Verteramo & Pantaleo Greco & María Aurora Rodríguez , 2020. "Daylight Saving Time and Spontaneous Deliveries: A Case–Control Study in Italy," IJERPH, MDPI, vol. 17(21), pages 1-9, November.
    17. Chiara Tarracchini & Giulia Alessandri & Federico Fontana & Sonia Mirjam Rizzo & Gabriele Andrea Lugli & Massimiliano Giovanni Bianchi & Leonardo Mancabelli & Giulia Longhi & Chiara Argentini & Laura , 2023. "Genetic strategies for sex-biased persistence of gut microbes across human life," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    18. R. Padmasaranya & Kaviya.M & G.Shravanthi & Vadivelan.K, 2020. "To Find the Quality of Life in Multiparae Women Who Have Undergone Multiple C-Section," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 7(3), pages 113-114, March.
    19. Monika Bączkowska & Katarzyna Kosińska-Kaczyńska & Magdalena Zgliczyńska & Robert Brawura-Biskupski-Samaha & Beata Rebizant & Michał Ciebiera, 2022. "Epidemiology, Risk Factors, and Perinatal Outcomes of Placental Abruption—Detailed Annual Data and Clinical Perspectives from Polish Tertiary Center," IJERPH, MDPI, vol. 19(9), pages 1-14, April.
    20. Rubén Aragón-Martín & María del Mar Gómez-Sánchez & David Jiménez-Pavón & José Manuel Martínez-Nieto & Mónica Schwarz-Rodríguez & Carmen Segundo-Iglesias & José Pedro Novalbos-Ruiz & María José Santi-, 2021. "A Multimodal Intervention for Prevention of Overweight and Obesity in Schoolchildren. A Protocol Study “PREVIENE-CÁDIZ”," IJERPH, MDPI, vol. 18(4), pages 1-19, February.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:8031-:d:438140. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.