IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i21p7895-d435961.html
   My bibliography  Save this article

Prenatal Exposure to Gutkha, a Globally Relevant Smokeless Tobacco Product, Induces Hepatic Changes in Adult Mice

Author

Listed:
  • Shannon Doherty Lyons

    (Department of Environmental Medicine, New York University School of Medicine, New York, NY 10010, USA)

  • Jason L. Blum

    (Department of Environmental Medicine, New York University School of Medicine, New York, NY 10010, USA
    Product Safety Labs, Dayton, NJ 08810, USA)

  • Carol Hoffman-Budde

    (Department of Environmental Medicine, New York University School of Medicine, New York, NY 10010, USA)

  • Pamela B. Tijerina

    (Department of Environmental Medicine, New York University School of Medicine, New York, NY 10010, USA)

  • M. Isabel Fiel

    (Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Daniel J. Conklin

    (American Heart Association-Tobacco Regulation and Addiction Center, University of Louisville, Kentucky, KY 40202, USA)

  • Francesca Gany

    (Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA)

  • Joseph A. Odin

    (Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Judith T. Zelikoff

    (Department of Environmental Medicine, New York University School of Medicine, New York, NY 10010, USA)

Abstract

Maternal exposures during pregnancy affect the onset and progression of adult diseases in the offspring. A prior mouse study indicated that maternal tobacco smoke exposure affects hepatic fibrosis in adult offspring. Gutkha, a broadly used smokeless tobacco (ST) product, is widely used by pregnant woman in many countries. The objective of this murine study was to evaluate whether oral maternal exposure to gutkha during pregnancy alters non-alcoholic fatty liver disease (NAFLD) in adult offspring: risk factors for the progression of NAFLD to cirrhosis in adults remain elusive. Buccal cavity ‘painting’ of pregnant mice with gutkha began on gestational days (GD) 2–4 and continued until parturition. Beginning at 12 weeks of age, a subset of offspring were transitioned to a high-fat diet (HFD). Results demonstrated that prenatal exposure to gutkha followed by an HFD in adulthood significantly increased the histologic evidence of fatty liver disease only in adult male offspring. Changes in hepatic fibrosis-related cytokines (interleukin (IL)-1b and IL-6) and in hepatic collagen mRNA expression were observed when comparing adult male offspring exposed to gutkha in utero to those not exposed. These findings indicate that maternal use of gutkha during pregnancy affects NAFLD in adult offspring in a sex-dependent manner.

Suggested Citation

  • Shannon Doherty Lyons & Jason L. Blum & Carol Hoffman-Budde & Pamela B. Tijerina & M. Isabel Fiel & Daniel J. Conklin & Francesca Gany & Joseph A. Odin & Judith T. Zelikoff, 2020. "Prenatal Exposure to Gutkha, a Globally Relevant Smokeless Tobacco Product, Induces Hepatic Changes in Adult Mice," IJERPH, MDPI, vol. 17(21), pages 1-15, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:7895-:d:435961
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/21/7895/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/21/7895/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Sungroul Kim, 2016. "Overview of Cotinine Cutoff Values for Smoking Status Classification," IJERPH, MDPI, vol. 13(12), pages 1-15, December.
    2. Daniel N. Willis & Mary A. Popovech & Francesca Gany & Carol Hoffman & Jason L. Blum & Judith T. Zelikoff, 2014. "Toxicity of Gutkha, a Smokeless Tobacco Product Gone Global: Is There More to the Toxicity than Nicotine?," IJERPH, MDPI, vol. 11(1), pages 1-15, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Marisa A. Patti & Craig Newschaffer & Melissa Eliot & Ghassan B. Hamra & Aimin Chen & Lisa A. Croen & M. Daniele Fallin & Irva Hertz-Picciotto & Geetika Kalloo & Jane C. Khoury & Bruce P. Lanphear & K, 2021. "Gestational Exposure to Phthalates and Social Responsiveness Scores in Children Using Quantile Regression: The EARLI and HOME Studies," IJERPH, MDPI, vol. 18(3), pages 1-17, January.
    2. Anna Maria Stabile & Alessandra Pistilli & Desirée Bartolini & Eleonora Angelucci & Marco Dell’Omo & Gabriele Di Sante & Mario Rende, 2022. "Short-Term Effects of Side-Stream Smoke on Nerve Growth Factor and Its Receptors TrKA and p75 NTR in a Group of Non-Smokers," IJERPH, MDPI, vol. 19(16), pages 1-11, August.
    3. Hyun-Seung Lee & Ji-Hyun Cho & Young-Jin Lee & Do-Sim Park, 2022. "Effect of Second-Hand Smoke Exposure on Establishing Urinary Cotinine-Based Optimal Cut-Off Values for Smoking Status Classification in Korean Adults," IJERPH, MDPI, vol. 19(13), pages 1-14, June.
    4. E. Melinda Mahabee-Gittens & Ashley L. Merianos & Patricia C. Fulkerson & Lara Stone & Georg E. Matt, 2019. "The Association of Environmental Tobacco Smoke Exposure and Inflammatory Markers in Hospitalized Children," IJERPH, MDPI, vol. 16(23), pages 1-10, November.
    5. Jiyeon Yang & Shervin Hashemi & Wonseok Han & Yoojin Song & Youngwook Lim, 2022. "Exposure and Risk Assessment of Second- and Third-Hand Tobacco Smoke Using Urinary Cotinine Levels in South Korea," IJERPH, MDPI, vol. 19(6), pages 1-19, March.
    6. Chenlin Yu & Ziteng Zhang & Yangang Liu & Ying Zong & Yongchun Chen & Xiuming Du & Jikuai Chen & Shijie Feng & Jinlian Hu & Shufang Cui & Guocai Lu, 2016. "Toxicity of Smokeless Tobacco Extract after 184-Day Repeated Oral Administration in Rats," IJERPH, MDPI, vol. 13(3), pages 1-16, March.
    7. Patrick B. Bendik & Sharyn M. Rutt & Brittany N. Pine & Connie S. Sosnoff & Benjamin C. Blount & Wanzhe Zhu & June Feng & Lanqing Wang, 2022. "Anabasine and Anatabine Exposure Attributable to Cigarette Smoking: National Health and Nutrition Examination Survey (NHANES) 2013–2014," IJERPH, MDPI, vol. 19(15), pages 1-13, August.
    8. Jasmine N Khouja & Marcus R Munafò & Caroline L Relton & Amy E Taylor & Suzanne H Gage & Rebecca C Richmond, 2020. "Investigating the added value of biomarkers compared with self-reported smoking in predicting future e-cigarette use: Evidence from a longitudinal UK cohort study," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-15, July.
    9. Kevin T. Caron & Wanzhe Zhu & John T. Bernert & Lanqing Wang & Benjamin C. Blount & Kristin Dortch & Ronald E. Hunter & Tia Harmon & J. Ricky Akins & James Tsai & David M. Homa & James L. Pirkle & Con, 2022. "Geometric Mean Serum Cotinine Concentrations Confirm a Continued Decline in Secondhand Smoke Exposure among U.S. Nonsmokers—NHANES 2003 to 2018," IJERPH, MDPI, vol. 19(10), pages 1-16, May.
    10. Melissa Parnell & Lawrence Foweather & Greg Whyte & John Dickinson & Ivan Gee, 2021. "Associations between Second-Hand Tobacco Smoke Exposure and Cardiorespiratory Fitness, Physical Activity, and Respiratory Health in Children," IJERPH, MDPI, vol. 18(21), pages 1-23, October.
    11. Won-Jun Choi & Ji-Won Lee & A Ra Cho & Yong-Jae Lee, 2019. "Dose-Dependent Toxic Effect of Cotinine-Verified Tobacco Smoking on Systemic Inflammation in Apparently Healthy Men and Women: A Nationwide Population-Based Study," IJERPH, MDPI, vol. 16(3), pages 1-11, February.
    12. Yukiko Nishihama & Shoji F. Nakayama & Takahiro Tabuchi & Tomohiko Isobe & Chau-Ren Jung & Miyuki Iwai-Shimada & Yayoi Kobayashi & Takehiro Michikawa & Makiko Sekiyama & Yu Taniguchi & Hiroshi Nitta &, 2020. "Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)," IJERPH, MDPI, vol. 17(15), pages 1-13, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:7895-:d:435961. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.