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Interactions among Obstructive Sleep Apnea Syndrome Severity, Sex, and Obesity on Circulatory Inflammatory Biomarkers in Patients with Suspected Obstructive Sleep Apnea Syndrome: A Retrospective, Cross-Sectional Study

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  • Ming-Feng Wu

    (Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan)

  • Yu-Hsuan Chen

    (Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan)

  • Hui-Chen Chen

    (Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan)

  • Wei-Chang Huang

    (Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Department of Life Sciences, National Chung-Hsing University, Taichung 402, Taiwan
    Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 350, Taiwan
    Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung 407, Taiwan)

Abstract

The interaction among obstructive sleep apnea syndrome (OSAS) severity, sex, and obesity on cardiovascular risk as determined by serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) remains unclear. Therefore, this study aimed to analyze individual associations between these three OSAS characteristics and three cardiovascular biomarkers and to determine whether the relationship was affected by other features in patients with suspected OSAS. For all participants ( n = 100), OSAS severity and sex had an interaction effect on IL-6 level ( p = 0.030). Specifically, the male patients ( p = 0.005) with severe OSAS had higher IL-6 levels than those with normal to moderate OSAS, but this relationship was not significant in the female patients ( p = 0.438). Moreover, in patients with normal to moderate OSAS ( p = 0.004), but not in those with severe OSAS ( p = 0.824), the female patients had higher IL-6 levels than the male patients. Both CRP ( p = 0.001) and IL-6 ( p = 0.000) levels were higher in the obese group than in the non-obese group independently of OSAS severity and sex. The three features had no effects on TNF-α level individually and interactively. Our findings suggest that circulatory inflammatory markers should be comprehensively evaluated in this population and that treatment and preventive therapies should be modified accordingly.

Suggested Citation

  • Ming-Feng Wu & Yu-Hsuan Chen & Hui-Chen Chen & Wei-Chang Huang, 2020. "Interactions among Obstructive Sleep Apnea Syndrome Severity, Sex, and Obesity on Circulatory Inflammatory Biomarkers in Patients with Suspected Obstructive Sleep Apnea Syndrome: A Retrospective, Cros," IJERPH, MDPI, vol. 17(13), pages 1-13, June.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:13:p:4701-:d:378310
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    References listed on IDEAS

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    1. Jinkwan Kim & Seok Jun Lee & Kyung-Mee Choi & Seung Ku Lee & Dae Wui Yoon & Seung Gwan Lee & Chol Shin, 2016. "Obstructive Sleep Apnea Is Associated with Elevated High Sensitivity C-Reactive Protein Levels Independent of Obesity: Korean Genome and Epidemiology Study," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-15, September.
    2. Luc F. Van Gaal & Ilse L. Mertens & Christophe E. De Block, 2006. "Mechanisms linking obesity with cardiovascular disease," Nature, Nature, vol. 444(7121), pages 875-880, December.
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    Cited by:

    1. Giannicola Iannella & Giuseppe Magliulo & Antonio Greco & Marco de Vincentiis & Massimo Ralli & Antonino Maniaci & Annalisa Pace & Claudio Vicini, 2022. "Obstructive Sleep Apnea Syndrome: From Symptoms to Treatment," IJERPH, MDPI, vol. 19(4), pages 1-3, February.
    2. Tien-Wei Hsu & Hsiu-Min Chen & Tien-Yu Chen & Che-Sheng Chu & Chih-Chuan Pan, 2021. "The Association between Use of Benzodiazepine Receptor Agonists and the Risk of Obstructive Sleep Apnea: A Nationwide Population-Based Nested Case-Control Study," IJERPH, MDPI, vol. 18(18), pages 1-12, September.

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