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Association of Serum Uric Acid with Cardiovascular Disease Risk Scores in Koreans

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  • Seung Yun Lee

    (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Inha University, Incheon 22332, Korea)

  • Won Park

    (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Inha University, Incheon 22332, Korea)

  • Young Ju Suh

    (Department of Biomedical Sciences, College of Medicine, Inha University, Incheon 22332, Korea)

  • Mie Jin Lim

    (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Inha University, Incheon 22332, Korea)

  • Seong-Ryul Kwon

    (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Inha University, Incheon 22332, Korea)

  • Joo-Hyun Lee

    (Department of Rheumatology, Inje University Ilsan Paik Hospital, Goyang 10380, Korea)

  • Young Bin Joo

    (Division of Rheumatology, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea)

  • Youn-Kyung Oh

    (Department of Biomedical Sciences, College of Medicine, Inha University, Incheon 22332, Korea)

  • Kyong-Hee Jung

    (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Inha University, Incheon 22332, Korea)

Abstract

As the prevalence of gout and hyperuricemia increases, the comorbidities of gout and hyperuricemia have become a public health burden. In particular, risks of cardiovascular disease (CVD)-related complications are increasing. However, a few guidelines exist for the management of hyperuricemia. This cross-sectional study aimed to investigate the association of serum uric acid with CVD risk in the general population of Korean adults. We examined cross-sectional data from the first and second years of the seventh Korea National Health and Nutrition Examination Survey 2016–2017. Among 16,277 participants, 8781 were analyzed. We estimated the CVD risk using a 10-year CVD risk score prediction formula. There was a significant association of serum uric acid with 10-year CVD risk scores after adjusting for physical activity, body mass index, serum creatinine, and alcohol consumption in both sexes ( p < 0.001). In the fitted fractional polynomial model, an approximate U-shaped association between serum uric acid levels and 10-year CVD risk scores was found in men. At the serum uric acid level of 6.9 mg/dL, the CVD risk was lowest. An approximate J-shaped association between serum uric acid levels and 10-year CVD risk scores was found in women. Our study showed that hyperuricemia was associated with an increased CVD risk. Hypouricemia was also associated with an increased CVD risk in men. We, therefore, recommend proper management of uric acid levels in the general population to reduce CVD risks.

Suggested Citation

  • Seung Yun Lee & Won Park & Young Ju Suh & Mie Jin Lim & Seong-Ryul Kwon & Joo-Hyun Lee & Young Bin Joo & Youn-Kyung Oh & Kyong-Hee Jung, 2019. "Association of Serum Uric Acid with Cardiovascular Disease Risk Scores in Koreans," IJERPH, MDPI, vol. 16(23), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:23:p:4632-:d:289433
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    References listed on IDEAS

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    1. Jia Liu & Zhan Zhao & Yongmin Mu & Xiaoping Zou & Dechun Zou & Jingbo Zhang & Shuo Chen & Lixin Tao & Xiuhua Guo, 2018. "Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study," IJERPH, MDPI, vol. 15(7), pages 1-10, July.
    2. Luc F. Van Gaal & Ilse L. Mertens & Christophe E. De Block, 2006. "Mechanisms linking obesity with cardiovascular disease," Nature, Nature, vol. 444(7121), pages 875-880, December.
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    Keywords

    uric acid; cardiovascular disease;

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