IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0166360.html
   My bibliography  Save this article

Leptin concentration and risk of coronary heart disease and stroke: A systematic review and meta-analysis

Author

Listed:
  • Han Yang
  • Wenzhi Guo
  • Jie Li
  • Shengli Cao
  • Jiakai Zhang
  • Jie Pan
  • Zhihui Wang
  • Peihao Wen
  • Xiaoyi Shi
  • Shuijun Zhang

Abstract

Background and purpose: Although high leptin concentration has been shown to be correlated with established vascular risk factors, epidemiologic studies have reported inconclusive results on the association between leptin and cardiovascular diseases (CVD). Therefore, a meta-analysis was performed to evaluate this issue. Methods: We searched Pubmed, Embase, and the Cochrane Library from their inception to Jan 2016 for both case-control and cohort studies that assessed leptin concentration and CVD risk. Reports with odds ratio (OR), risk ratio (RR) and corresponding 95% confidence intervals (CI) were considered. The data were extracted by two investigators independently. Results: A total of 13 epidemiologic studies totaling 4257 CVD patients and 26710 controls were included. A significant inverse association was shown between leptin and coronary heart disease (CHD), with an overall OR of 1.16 (95% CI: 1.02–1.32), but not for stroke (OR = 1.21, 95% CI 0.98–1.48) under sociodemographic adjustment. Further adjustment for additional cardiovascular risk factors resulted in ORs of 1.16 (95% CI 0.97–1.40) for CHD and 1.10 (95% CI 0.89–1.35) for stroke. The findings remained when analyses were restricted to high-quality studies and indicated OR estimates of 1.07 (95% CI 0.96–1.19) for CHD and 0.98 (95% CI 0.76–1.25) for stroke. In a subgroup meta-analysis, a high leptin level was not independently associated with CHD in both females (OR = 1.03, 95% CI 0.86–1.23) and males (OR = 1.09, 95% CI 0.95–1.26) or with stroke in both females (OR = 1.13, 95% CI 0.87–1.47) and males (OR = 0.80, 95% CI 0.59–1.09). There was no significant publication bias as suggested by Egger test outcomes. Conclusions: Our findings indicate that high leptin levels may not be associated with risks of CHD and stroke. Further large, well-designed prospective cohort studies are needed to fully evaluate the role of leptin on the risk of CVD.

Suggested Citation

  • Han Yang & Wenzhi Guo & Jie Li & Shengli Cao & Jiakai Zhang & Jie Pan & Zhihui Wang & Peihao Wen & Xiaoyi Shi & Shuijun Zhang, 2017. "Leptin concentration and risk of coronary heart disease and stroke: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0166360
    DOI: 10.1371/journal.pone.0166360
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166360
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0166360&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0166360?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Graham M. Lord & Giuseppe Matarese & Jane K. Howard & Richard J. Baker & Stephen R. Bloom & Robert I. Lechler, 1998. "Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression," Nature, Nature, vol. 394(6696), pages 897-901, August.
    2. Luc F. Van Gaal & Ilse L. Mertens & Christophe E. De Block, 2006. "Mechanisms linking obesity with cardiovascular disease," Nature, Nature, vol. 444(7121), pages 875-880, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hwi Jun Kim & So Yeon Oh & Dong-Woo Choi & Eun-Cheol Park, 2019. "The Association between Eating-Out Rate and BMI in Korea," IJERPH, MDPI, vol. 16(17), pages 1-14, August.
    2. Wendy Hens & Dirk Vissers & Nick Verhaeghe & Jan Gielen & Luc Van Gaal & Jan Taeymans, 2021. "Unsupervised Exercise Training Was Not Found to Improve the Metabolic Health or Phenotype over a 6-Month Dietary Intervention: A Randomised Controlled Trial with an Embedded Economic Analysis," IJERPH, MDPI, vol. 18(15), pages 1-13, July.
    3. Eunkyung Lee & Vanessa Kady & Eric Han & Kayla Montan & Marjona Normuminova & Michael J. Rovito, 2022. "Healthy Eating and Mortality among Breast Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies," IJERPH, MDPI, vol. 19(13), pages 1-24, June.
    4. Kim, Ji-Il & Yu, Chia-Yuan & Woo, Ayoung, 2023. "The impacts of visual street environments on obesity: The mediating role of walking behaviors," Journal of Transport Geography, Elsevier, vol. 109(C).
    5. Sudhirsen Kowlessur & Zhibin Hu & Jaysing Heecharan & Jianming Wang & Juncheng Dai & Jaakko O. Tuomilehto & Stefan Söderberg & Paul Zimmet & Noël C. Barengo, 2018. "Predictors of Hypertension in Mauritians with Normotension and Prehypertension at Baseline: A Cohort Study," IJERPH, MDPI, vol. 15(7), pages 1-12, July.
    6. Ming-Ling Chang & Chia-Jung Kuo & Hsin-Chih Huang & Yin-Yi Chu & Cheng-Tang Chiu, 2016. "Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance: Homeostasis of Metabolism and Immunity," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-12, November.
    7. Cristhiane Favero de Aguiar & Pedro M Mendes Moraes Vieira, 2018. "M1 Extra Weight in the Balance: The Role of Macrophages in Obesity," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 7(4), pages 72-75, June.
    8. Esposito, Lucio & Villaseñor, Adrián & Rodríguez, Enrique Cuevas & Millett, Christopher, 2020. "The economic gradient of obesity in Mexico: Independent predictive roles of absolute and relative wealth by gender," Social Science & Medicine, Elsevier, vol. 250(C).
    9. Emyr Reisha Isaura & Yang-Ching Chen & Shwu-Huey Yang, 2018. "The Association of Food Consumption Scores, Body Shape Index, and Hypertension in a Seven-Year Follow-Up among Indonesian Adults: A Longitudinal Study," IJERPH, MDPI, vol. 15(1), pages 1-12, January.
    10. Mutaz Ombada & Mulham Ombada, 2020. "Association between Healthy Lifestyle and Management of Hypertension; A Descriptive Study undertaking Sudanese Adult," Global Journal of Health Science, Canadian Center of Science and Education, vol. 12(1), pages 106-106, January.
    11. Seung Yun Lee & Won Park & Young Ju Suh & Mie Jin Lim & Seong-Ryul Kwon & Joo-Hyun Lee & Young Bin Joo & Youn-Kyung Oh & Kyong-Hee Jung, 2019. "Association of Serum Uric Acid with Cardiovascular Disease Risk Scores in Koreans," IJERPH, MDPI, vol. 16(23), pages 1-10, November.
    12. Sung-Woo Kim & Won-Sang Jung & Wonil Park & Hun-Young Park, 2019. "Twelve Weeks of Combined Resistance and Aerobic Exercise Improves Cardiometabolic Biomarkers and Enhances Red Blood Cell Hemorheological Function in Obese Older Men: A Randomized Controlled Trial," IJERPH, MDPI, vol. 16(24), pages 1-11, December.
    13. Dirk Vissers & Wendy Hens & Jan Taeymans & Jean-Pierre Baeyens & Jacques Poortmans & Luc Van Gaal, 2013. "The Effect of Exercise on Visceral Adipose Tissue in Overweight Adults: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-10, February.
    14. Ming-Feng Wu & Yu-Hsuan Chen & Hui-Chen Chen & Wei-Chang Huang, 2020. "Interactions among Obstructive Sleep Apnea Syndrome Severity, Sex, and Obesity on Circulatory Inflammatory Biomarkers in Patients with Suspected Obstructive Sleep Apnea Syndrome: A Retrospective, Cros," IJERPH, MDPI, vol. 17(13), pages 1-13, June.
    15. Linda P Bolin & Carolyn E Horne & Patricia B Crane & James R Powell, 2018. "Low‐salt diet adherence in African Americans with hypertension," Journal of Clinical Nursing, John Wiley & Sons, vol. 27(19-20), pages 3750-3757, October.
    16. Goosby, Bridget J. & Cheadle, Jacob E. & McDade, Thomas, 2016. "Birth weight, early life course BMI, and body size change: Chains of risk to adult inflammation?," Social Science & Medicine, Elsevier, vol. 148(C), pages 102-109.
    17. Marzena Ratajczak & Damian Skrypnik & Paweł Bogdański & Edyta Mądry & Jarosław Walkowiak & Monika Szulińska & Janusz Maciaszek & Matylda Kręgielska-Narożna & Joanna Karolkiewicz, 2019. "Effects of Endurance and Endurance–Strength Training on Endothelial Function in Women with Obesity: A Randomized Trial," IJERPH, MDPI, vol. 16(21), pages 1-13, November.
    18. Cristhiane Favero de Aguiar & Pedro M Mendes Moraes Vieira, 2018. "M1 Extra Weight in the Balance: The Role of Macrophages in Obesity," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 7(4), pages 1-4, June.
    19. Marko Sysi-Aho & Andrey Ermolov & Peddinti V Gopalacharyulu & Abhishek Tripathi & Tuulikki Seppänen-Laakso & Johanna Maukonen & Ismo Mattila & Suvi T Ruohonen & Laura Vähätalo & Laxman Yetukuri & Tain, 2011. "Metabolic Regulation in Progression to Autoimmune Diabetes," PLOS Computational Biology, Public Library of Science, vol. 7(10), pages 1-16, October.
    20. Xiaowen Wang & Shanshan Yao & Mengying Wang & Guiying Cao & Zishuo Chen & Ziting Huang & Yao Wu & Ling Han & Beibei Xu & Yonghua Hu, 2020. "Multimorbidity among Two Million Adults in China," IJERPH, MDPI, vol. 17(10), pages 1-13, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0166360. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.