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Depression and Objectively Measured Physical Activity: A Systematic Review and Meta-Analysis

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  • Vincenza Gianfredi

    (School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy
    Accademia Lombarda di Sanità Pubblica, Consorzio Pavese Studi Post-Universitari, Unit of Forensic Medicine and Forensic Sciences, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy
    CAPHRI Care and Public Health Research Institute, Maastricht University, 6211 Maastricht, The Netherlands)

  • Lorenzo Blandi

    (Accademia Lombarda di Sanità Pubblica, Consorzio Pavese Studi Post-Universitari, Unit of Forensic Medicine and Forensic Sciences, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy
    Unit of Forensic Medicine and Forensic Sciences, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy)

  • Stefano Cacitti

    (Accademia Lombarda di Sanità Pubblica, Consorzio Pavese Studi Post-Universitari, Unit of Forensic Medicine and Forensic Sciences, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy
    Unit of Forensic Medicine and Forensic Sciences, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy)

  • Mirko Minelli

    (Accademia Lombarda di Sanità Pubblica, Consorzio Pavese Studi Post-Universitari, Unit of Forensic Medicine and Forensic Sciences, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy
    Unit of Forensic Medicine and Forensic Sciences, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy)

  • Carlo Signorelli

    (School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy
    Accademia Lombarda di Sanità Pubblica, Consorzio Pavese Studi Post-Universitari, Unit of Forensic Medicine and Forensic Sciences, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy)

  • Andrea Amerio

    (Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy
    IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
    Mood Disorders Program, Tufts Medical Center, Boston, MA 02111, USA)

  • Anna Odone

    (School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy
    Accademia Lombarda di Sanità Pubblica, Consorzio Pavese Studi Post-Universitari, Unit of Forensic Medicine and Forensic Sciences, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy)

Abstract

Depression is a major contributor to the overall global burden of disease, with high prevalence and relapse rate. Several factors have been considered in order to reduce the depression burden. Among them, physical activity (PA) showed a potential protective role. However, evidence is contrasting probably because of the differences in PA measurement. The aim of this systematic review with meta-analysis is to assess the association between objectively measured PA and incident and prevalent depression. The systematic review was conducted according to methods recommended by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Relevant papers published through 31 August 2019 were identified searching through the electronic databases PubMed/MEDLINE, Excerpta Medica dataBASE (Embase), PsycINFO, Scopus, Web of Science (WoS), and the Cochrane Library. All analyses were conducted using ProMeta3. Finally, 42 studies met inclusion criteria. The overall Effect size (ES) of depression for the highest vs. the lowest level of PA was −1.16 [(95% CI = −1.41; −0.91), p -value < 0.001] based on 37,408 participants. The results of the meta-analysis showed a potential protective effect of PA on prevalent and incident depression.

Suggested Citation

  • Vincenza Gianfredi & Lorenzo Blandi & Stefano Cacitti & Mirko Minelli & Carlo Signorelli & Andrea Amerio & Anna Odone, 2020. "Depression and Objectively Measured Physical Activity: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(10), pages 1-20, May.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:10:p:3738-:d:362690
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    References listed on IDEAS

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    1. Vincenza Gianfredi & Daniele Nucci & Cristina Fatigoni & Tania Salvatori & Milena Villarini & Massimo Moretti, 2020. "Extent of Primary DNA Damage Measured by the Comet Assay in Health Professionals Exposed to Antineoplastic Drugs: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(2), pages 1-21, January.
    2. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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    4. Daniele Nucci & Cristina Fatigoni & Andrea Amerio & Anna Odone & Vincenza Gianfredi, 2020. "Red and Processed Meat Consumption and Risk of Depression: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(18), pages 1-20, September.
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    7. Vincenza Gianfredi & Pietro Ferrara & Flavia Pennisi & Giulia Casu & Andrea Amerio & Anna Odone & Daniele Nucci & Monica Dinu, 2022. "Association between Daily Pattern of Physical Activity and Depression: A Systematic Review," IJERPH, MDPI, vol. 19(11), pages 1-12, May.
    8. Ambra Gentile & Marianna Alesi & Barbara Caci, 2022. "Protective and Educational Effects of Physical Activity Practice on Mental Health in Young Age during COVID-19 Lockdown," Sustainability, MDPI, vol. 15(1), pages 1-13, December.
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