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Extent of Primary DNA Damage Measured by the Comet Assay in Health Professionals Exposed to Antineoplastic Drugs: A Systematic Review and Meta-Analysis

Author

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  • Vincenza Gianfredi

    (Department of Pharmaceutical Sciences (Unit of Public Health), University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Post Graduate School of Hygiene and Preventive Medicine, Department of Experimental Medicine, University of Perugia, Piazzale Gambuli, 06122 Perugia, Italy
    Shared first authorship. These two Authors equally contribute to the manuscript.)

  • Daniele Nucci

    (Digestive Endoscopy Unit, IRCCS Istituto Oncologico Veneto, Via Gattamelata 64, 35128 Padova, Italy
    Shared first authorship. These two Authors equally contribute to the manuscript.)

  • Cristina Fatigoni

    (Department of Pharmaceutical Sciences (Unit of Public Health), University of Perugia, Via del Giochetto, 06122 Perugia, Italy)

  • Tania Salvatori

    (Department of Pharmaceutical Sciences (Unit of Public Health), University of Perugia, Via del Giochetto, 06122 Perugia, Italy)

  • Milena Villarini

    (Department of Pharmaceutical Sciences (Unit of Public Health), University of Perugia, Via del Giochetto, 06122 Perugia, Italy)

  • Massimo Moretti

    (Department of Pharmaceutical Sciences (Unit of Public Health), University of Perugia, Via del Giochetto, 06122 Perugia, Italy)

Abstract

Background: Antineoplastic drugs (ANDs) are a broad group of chemicals showing, at the same time, carcinogenic effects. The potential, albeit true, risk of side effects cannot be accepted, especially if resulting from occupational exposure. The aim of this study was to evaluate the association between occupational exposure to ANDs and the extent of primary DNA damage in health professionals. Methods: A systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed/Medline, Web of Science, and Scopus were used to perform the literature search. The databases were examined in July 2019. Sub-group, moderator, and cumulative analyses were conducted. The trim and fill method was used in the case of potential publication bias. Results: Twenty studies were included in the qualitative analysis, and 19 in quantitative evaluation. The pooled effect size was 1.27 [(95% confidence interval (CI) = 0.66–1.88), p = 0.000] based on 1569 subjects. The moderator analysis by duration of exposure showed a positive association between duration of exposure and primary DNA damage. Conclusions: This systematic review clearly shows a significant association between occupational exposure to ANDs and the extent of primary DNA damage in health professionals. Considering these results, health professionals should be warned against this potential occupational risk.

Suggested Citation

  • Vincenza Gianfredi & Daniele Nucci & Cristina Fatigoni & Tania Salvatori & Milena Villarini & Massimo Moretti, 2020. "Extent of Primary DNA Damage Measured by the Comet Assay in Health Professionals Exposed to Antineoplastic Drugs: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(2), pages 1-21, January.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:2:p:523-:d:308583
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    Cited by:

    1. Daniele Nucci & Cristina Fatigoni & Andrea Amerio & Anna Odone & Vincenza Gianfredi, 2020. "Red and Processed Meat Consumption and Risk of Depression: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(18), pages 1-20, September.
    2. Vincenza Gianfredi & Lorenzo Blandi & Stefano Cacitti & Mirko Minelli & Carlo Signorelli & Andrea Amerio & Anna Odone, 2020. "Depression and Objectively Measured Physical Activity: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(10), pages 1-20, May.

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