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Higher Risk of Gastric Helicobacter pylori Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan

Author

Listed:
  • Xin Li

    (Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    Shared first authorship.)

  • Hitesh Singh Chaouhan

    (Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    Shared first authorship.)

  • Ching-Hao Li

    (Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    Shared first authorship.)

  • Tung-Min Yu

    (Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 404, Taiwan)

  • I-Kuan Wang

    (Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    Division of Nephrology, China Medical University Hospital, Taichung 404, Taiwan
    Department of Internal Medicine, School of Medicine, China Medical University, Taichung 404, Taiwan)

  • Cheng-Li Lin

    (Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan)

  • Chi-Yuan Li

    (Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    Department of Anesthesiology, China Medical University Hospital, Taichung 404, Taiwan)

  • Kuo-Ting Sun

    (Department of Pediatric Dentistry, China Medical University Hospital, Taichung 404, Taiwan
    School of Dentistry, College of Dentistry, China Medical University, Taichung 404, Taiwan)

Abstract

Periodontitis is the most prevalent chronic inflammatory oral disease that is characterized by tooth loss and is commonly associated with several systemic inflammatory diseases. Some epidemiological studies suggest that those suffering from periodontitis might be at a greater risk of developing gastric Helicobacter pylori ( Hp ) infection; however, evidence that showing the association between periodontitis and the risk of gastric Hp infection is less clear. We conducted a large-scale, population-based study in Taiwan with a 13-year follow-up period to evaluate the risk of gastric Hp in a periodontitis patient cohort. To conduct this study, we used epidemiological data from the Taiwanese Longitudinal National Health Insurance Research Database (NHIRD) from 2000 to 2013. We selected 134,474 participants (64,868 males and 69,606 females with a minimum age of 20 years), with and without periodontitis, and matched patient cohort groups for age, sex, index year, and co-morbidities. The Cox proportional hazards regression model was used to examine the risk of gastric Hp infection in patients with periodontitis. Patients with periodontitis exhibited a higher risk of developing gastric Hp infection compared to those individuals/groups without periodontitis (1.35 vs. 0.87 per 1000 person-years, adjusted the hazards ratio (aHR 1.52), and 95% confidence intervals (CIs) 1.38–1.67, p < 0.001). The risk of gastric Hp infection persisted even after stratifying by age (aHR = 1.96 (1.79–2.13) for 50–64 years and 1.70 (1.49–1.94) for ≥65 years), gender (aHR = 1.20 (1.11–1.29) for men), and presence of comorbidities of hypertension (aHR = 1.24 (1.11–1.38)), hyperlipidemia (aHR = 1.28 (1.14–1.42)), COPD (aHR = 1.45 (1.31–1.61)), CLD (aHR = 1.62 (1.47–1.77)) and CKD (aHR = 1.44 (1.04–1.99)). Overall, our findings showed that periodontitis patients have a greater risk for gastric Hp than individuals without periodontitis. Clinicians should perform regular good oral hygiene practices, along with newer treatments, for patients with periodontitis, especially those at higher risk of gastric Hp infection.

Suggested Citation

  • Xin Li & Hitesh Singh Chaouhan & Ching-Hao Li & Tung-Min Yu & I-Kuan Wang & Cheng-Li Lin & Chi-Yuan Li & Kuo-Ting Sun, 2021. "Higher Risk of Gastric Helicobacter pylori Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan," IJERPH, MDPI, vol. 18(21), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11678-:d:673823
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    References listed on IDEAS

    as
    1. Hui-Chieh Yu & Tsung-Po Chen & Chia-Yi Wei & Yu-Chao Chang, 2018. "Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan," IJERPH, MDPI, vol. 15(5), pages 1-8, May.
    2. Dye, B.A. & Kruszon-Moran, D. & McQuillan, G., 2002. "The relationship between periodontal disease attributes and Helicobacter pylori infection among adults in the United States," American Journal of Public Health, American Public Health Association, vol. 92(11), pages 1809-1815.
    Full references (including those not matched with items on IDEAS)

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