IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i8p2637-d344596.html
   My bibliography  Save this article

Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan

Author

Listed:
  • Chien-Fang Tseng

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
    These authors contributed equally to this work.)

  • Kun-Huang Chen

    (Department of Artificial Intelligence, CTBC Business School, Tainan 709, Taiwan
    These authors contributed equally to this work.)

  • Hui-Chieh Yu

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Fu-Mei Huang

    (Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Yu-Chao Chang

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

Abstract

Multiple sclerosis (MS) is an inflammatory neurological disease characterized by autoimmune-mediated demyelination of the central nervous system. Genetic and environmental factors may contribute to the development of MS. This has not been confirmed yet. Dental amalgam has long been controversial in MS due to its mercury content but the toxicological implications of mercury-containing amalgam fillings (AMF) for MS remain to be elucidated. We conducted a case–control study to investigate the association between AMF and the risk of MS from the Taiwanese National Health Insurance Research Database (NHIRD). Case ( n = 612) and control ( n = 612) groups were matched by sex, age, urbanization level, monthly income, and Charlson comorbidity index by propensity score matched with a 1:1 ratio from 2000 to 2013. Differences between cases and controls was not statistically significant (OR: 0.82, 95% CI = 0.65–1.05). In subjects stratified by gender, MS was also not associated with AMF for women (OR: 0.743, 95% CI = 0.552–1.000) and men (OR: 1.006, 95% CI = 0.670–1.509), respectively. In summary, this Taiwanese nationwide population-based case–control study did not find an association between MS and AMF.

Suggested Citation

  • Chien-Fang Tseng & Kun-Huang Chen & Hui-Chieh Yu & Fu-Mei Huang & Yu-Chao Chang, 2020. "Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan," IJERPH, MDPI, vol. 17(8), pages 1-7, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2637-:d:344596
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/8/2637/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/8/2637/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Hui-Chieh Yu & Tsung-Po Chen & Chia-Yi Wei & Yu-Chao Chang, 2018. "Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan," IJERPH, MDPI, vol. 15(5), pages 1-8, May.
    2. Li-Chiu Yang & Yih-Jane Suen & Yu-Hsun Wang & Tai-Chen Lin & Hui-Chieh Yu & Yu-Chao Chang, 2020. "The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-10, January.
    3. Chang-Kai Chen & Jing-Yang Huang & Yung-Tsan Wu & Yu-Chao Chang, 2018. "Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study," IJERPH, MDPI, vol. 15(8), pages 1-8, July.
    4. Chien-Fang Tseng & Kun-Huang Chen & Hui-Chieh Yu & Yu-Chao Chang, 2020. "Association between Dental Amalgam Filling and Essential Tremor: A Nationwide Population-Based Case Control Study in Taiwan," IJERPH, MDPI, vol. 17(3), pages 1-7, January.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yung-Kai Huang & Li-Chiu Yang & Yu-Hsun Wang & Yu-Chao Chang, 2021. "Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study," IJERPH, MDPI, vol. 18(4), pages 1-10, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yung-Kai Huang & Yu-Hsun Wang & Yu-Chao Chang, 2020. "Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study," IJERPH, MDPI, vol. 17(10), pages 1-8, May.
    2. Li-Chiu Yang & Yih-Jane Suen & Yu-Hsun Wang & Tai-Chen Lin & Hui-Chieh Yu & Yu-Chao Chang, 2020. "The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-10, January.
    3. Soo Hwan Byun & Chanyang Min & Seok Jin Hong & Hyo Geun Choi & Dong Hee Koh, 2020. "Analysis of the Relation between Periodontitis and Chronic Gastritis/Peptic Ulcer: A Cross-Sectional Study Using KoGES HEXA Data," IJERPH, MDPI, vol. 17(12), pages 1-10, June.
    4. Yung-Kai Huang & Li-Chiu Yang & Yu-Hsun Wang & Yu-Chao Chang, 2021. "Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study," IJERPH, MDPI, vol. 18(4), pages 1-10, February.
    5. Young Jin Ra & Young Jin Tak & Yun Jin Kim & Sang Yeoup Lee & Jeong Gyu Lee & Yu Hyeon Yi & Young Hye Cho & Hye Rim Hwang & Seung Hun Lee & Eun Ju Park & Young In Lee, 2020. "Association of Work Patterns and Periodontitis Prevalence in Korean Adults Aged 50 Years or Older: A Nationwide Representative Study," IJERPH, MDPI, vol. 17(11), pages 1-11, June.
    6. Xin Li & Hitesh Singh Chaouhan & Ching-Hao Li & Tung-Min Yu & I-Kuan Wang & Cheng-Li Lin & Chi-Yuan Li & Kuo-Ting Sun, 2021. "Higher Risk of Gastric Helicobacter pylori Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan," IJERPH, MDPI, vol. 18(21), pages 1-11, November.
    7. Yi-Wei Kao & Ben-Chang Shia & Huei-Chen Chiang & Mingchih Chen & Szu-Yuan Wu, 2021. "Association of Tooth Scaling with Acute Myocardial Infarction and Analysis of the Corresponding Medical Expenditure: A Nationwide Population-Based Study," IJERPH, MDPI, vol. 18(14), pages 1-8, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2637-:d:344596. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.