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Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan

Author

Listed:
  • Chien-Fang Tseng

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
    These authors contributed equally to this work.)

  • Kun-Huang Chen

    (Department of Artificial Intelligence, CTBC Business School, Tainan 709, Taiwan
    These authors contributed equally to this work.)

  • Hui-Chieh Yu

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Fu-Mei Huang

    (Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Yu-Chao Chang

    (School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

Abstract

Multiple sclerosis (MS) is an inflammatory neurological disease characterized by autoimmune-mediated demyelination of the central nervous system. Genetic and environmental factors may contribute to the development of MS. This has not been confirmed yet. Dental amalgam has long been controversial in MS due to its mercury content but the toxicological implications of mercury-containing amalgam fillings (AMF) for MS remain to be elucidated. We conducted a case–control study to investigate the association between AMF and the risk of MS from the Taiwanese National Health Insurance Research Database (NHIRD). Case ( n = 612) and control ( n = 612) groups were matched by sex, age, urbanization level, monthly income, and Charlson comorbidity index by propensity score matched with a 1:1 ratio from 2000 to 2013. Differences between cases and controls was not statistically significant (OR: 0.82, 95% CI = 0.65–1.05). In subjects stratified by gender, MS was also not associated with AMF for women (OR: 0.743, 95% CI = 0.552–1.000) and men (OR: 1.006, 95% CI = 0.670–1.509), respectively. In summary, this Taiwanese nationwide population-based case–control study did not find an association between MS and AMF.

Suggested Citation

  • Chien-Fang Tseng & Kun-Huang Chen & Hui-Chieh Yu & Fu-Mei Huang & Yu-Chao Chang, 2020. "Dental Amalgam Fillings and Multiple Sclerosis: A Nationwide Population-Based Case–Control Study in Taiwan," IJERPH, MDPI, vol. 17(8), pages 1-7, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2637-:d:344596
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    References listed on IDEAS

    as
    1. Chang-Kai Chen & Jing-Yang Huang & Yung-Tsan Wu & Yu-Chao Chang, 2018. "Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study," IJERPH, MDPI, vol. 15(8), pages 1-8, July.
    2. Chien-Fang Tseng & Kun-Huang Chen & Hui-Chieh Yu & Yu-Chao Chang, 2020. "Association between Dental Amalgam Filling and Essential Tremor: A Nationwide Population-Based Case Control Study in Taiwan," IJERPH, MDPI, vol. 17(3), pages 1-7, January.
    3. Hui-Chieh Yu & Tsung-Po Chen & Chia-Yi Wei & Yu-Chao Chang, 2018. "Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan," IJERPH, MDPI, vol. 15(5), pages 1-8, May.
    4. Li-Chiu Yang & Yih-Jane Suen & Yu-Hsun Wang & Tai-Chen Lin & Hui-Chieh Yu & Yu-Chao Chang, 2020. "The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-10, January.
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    Cited by:

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