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Genetics and pathogenesis of inflammatory bowel disease

Author

Listed:
  • Bernard Khor

    (Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School
    Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School
    Pathology Service, Massachusetts General Hospital)

  • Agnès Gardet

    (Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School
    Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School)

  • Ramnik J. Xavier

    (Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School
    Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School
    The Broad Institute of MIT and Harvard)

Abstract

Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution. Complex interfaces integrate local host and microbial signals to activate appropriate effector programs selectively and even drive plasticity between these programs. In addition, genetic studies and mouse models have emphasized the role of genetic predispositions and how they affect interactions with microbial and environmental factors, leading to pro-colitogenic perturbations of the host–commensal relationship.

Suggested Citation

  • Bernard Khor & Agnès Gardet & Ramnik J. Xavier, 2011. "Genetics and pathogenesis of inflammatory bowel disease," Nature, Nature, vol. 474(7351), pages 307-317, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7351:d:10.1038_nature10209
    DOI: 10.1038/nature10209
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    Cited by:

    1. Atle van Beelen Granlund & Arnar Flatberg & Ann E Østvik & Ignat Drozdov & Bjørn I Gustafsson & Mark Kidd & Vidar Beisvag & Sverre H Torp & Helge L Waldum & Tom Christian Martinsen & Jan Kristian Damå, 2013. "Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-14, February.
    2. Fahad M. Aldakheel, 2021. "Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics," IJERPH, MDPI, vol. 18(22), pages 1-29, November.
    3. Hagar Taman & Christopher G Fenton & Endre Anderssen & Jon Florholmen & Ruth H Paulssen, 2021. "DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-17, April.
    4. Antonella Gagliardi & Valentina Totino & Fatima Cacciotti & Valerio Iebba & Bruna Neroni & Giulia Bonfiglio & Maria Trancassini & Claudio Passariello & Fabrizio Pantanella & Serena Schippa, 2018. "Rebuilding the Gut Microbiota Ecosystem," IJERPH, MDPI, vol. 15(8), pages 1-24, August.

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