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Relationship between Job Stress and 5-HT2A Receptor Polymorphisms on Self-Reported Sleep Quality in Physicians in Urumqi (Xinjiang, China): A Cross-Sectional Study

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  • Xiaoyan Gao

    (Department of Public Health, Xinjiang Medical University, Urumqi 830011, China
    These authors contributed equally to this work.)

  • Hua Ge

    (Department of Public Health, Xinjiang Medical University, Urumqi 830011, China
    These authors contributed equally to this work.)

  • Yu Jiang

    (Department of Public Health and Management, Wenzhou Medical University, Wenzhou 325000, China)

  • Yulong Lian

    (Department of Public Health, Nantong University, Nantong 226000, China)

  • Chen Zhang

    (Hospital Management Office, Xinjiang Medical University, Urumqi 830011, China)

  • Jiwen Liu

    (Department of Public Health, Xinjiang Medical University, Urumqi 830011, China)

Abstract

The serotonin receptor (5-HTR) plays a key role in sleep quality regulation. Job-related stress is an important factor that influences sleep quality. However, few reports on the interaction between 5-HTR2A polymorphisms and job stress, and how they may impact upon sleep quality are available. Therefore this study investigated the effects of job stress, 5-HTR2A polymorphisms, and their interaction on sleep quality, in physicians. Using a two-stage stratified sampling method, 918 participants were initially invited to participate in the study. After screening for study inclusion and exclusion criteria, 504 subjects were eventually included in the study. Job stress and sleep quality were assessed using the Job Stress Survey (JSS) and Pittsburgh Sleep Quality Index (PSQI), respectively. The 5-HTR2A receptor gene polymorphisms T102C and -1438G/A of were determined using polymerase chain reaction-restriction fragment length polymorphism. Job stress was significantly associated with sleep quality. High levels of job stress were linked to a higher risk of poor sleep quality compared to low or moderate levels [odds ratio (OR) = 2.909, 95% confidence interval (CI): 1.697–4.986]. High levels of stress may reduce subjects’ sleep quality, leading to an increase the likelihood of sleep disturbances and subsequent daytime dysfunction. The 5-HTR2A receptor gene polymorphism T102C was not significantly associated with sleep quality in this study, however, the -1438G/A polymorphism was significantly associated with sleep quality. The GG genotype of the -1438G/A polymorphism was linked to poorer sleep quality. When compared with subjects with low job-related stress levels×AG/AA genotype (OR = 2.106, 95% CI: 1.278–3.471), physicians with high job-related stress levels×GG genotype had a higher risk of experiencing poor sleep quality (OR = 13.400, 95% CI: 3.143–57.137). The findings of our study indicate that job stress and 5-HTR2A receptor gene polymorphisms are associated with sleep quality in physicians. Subjects with high job stress level or/and the -1438G/A GG genotype were more likely to report poor sleep quality, and furthermore, their combination effect on sleep quality was higher than their independent effects, so it may be suggested that job-related stress and genes have a cumulative effect on sleep quality; that is, stress can increase the risk of poor sleep quality, but this effect is worse in a group of people with specific gene polymorphisms.

Suggested Citation

  • Xiaoyan Gao & Hua Ge & Yu Jiang & Yulong Lian & Chen Zhang & Jiwen Liu, 2018. "Relationship between Job Stress and 5-HT2A Receptor Polymorphisms on Self-Reported Sleep Quality in Physicians in Urumqi (Xinjiang, China): A Cross-Sectional Study," IJERPH, MDPI, vol. 15(5), pages 1-15, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:5:p:1034-:d:148184
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    References listed on IDEAS

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    4. Baodong Qin & Zhen Sun & Yan Liang & Zaixing Yang & Renqian Zhong, 2014. "The Association of 5-HT2A, 5-HTT, and LEPR Polymorphisms with Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-9, April.
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    1. Ting Jiang & Xue Li & Li Ning & Jiwen Liu, 2019. "Cross-Sectional Survey of Mental Health Risk Factors and Comparison of the Monoamine oxidase A Gene DNA Methylation Level in Different Mental Health Conditions among Oilfield Workers in Xinjiang, Chin," IJERPH, MDPI, vol. 17(1), pages 1-15, December.

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    Keywords

    physicians; job stress; 5-HT2A; sleep quality;
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