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Cross-Sectional Survey of Mental Health Risk Factors and Comparison of the Monoamine oxidase A Gene DNA Methylation Level in Different Mental Health Conditions among Oilfield Workers in Xinjiang, China

Author

Listed:
  • Ting Jiang

    (Department of Public Health, Xinjiang Medical University, Urumqi 830011, China
    These authors contributed equally to this work.)

  • Xue Li

    (Department of Public Health, Xinjiang Medical University, Urumqi 830011, China
    These authors contributed equally to this work.)

  • Li Ning

    (Department of Public Health, Xinjiang Medical University, Urumqi 830011, China
    These authors contributed equally to this work.)

  • Jiwen Liu

    (Department of Public Health, Xinjiang Medical University, Urumqi 830011, China)

Abstract

The incidence of psychological problems among occupational groups is becoming increasingly more serious, and adverse psychological conditions will seriously affect the working ability of occupational groups and harm the health of their bodies. This study adopted a multi-stage stratified cluster sampling method to conduct a cross-sectional survey on the mental health of 3631 oil workers in Karamay, Xinjiang from March 2017 to June 2018. The mental health status of oil workers was evaluated using the Symptom Checklist-90, and mental health risk factors were evaluated. The correlation between the monoamine oxidase A ( MAOA ) gene and mental health was analyzed, and the DNA methylation level of the MAOA gene was compared between the normal group and the abnormal group. The results show the incidence of mental health problems among oil workers according to differences in age, nationality, type of work, length of service, professional title, shift work, and marital status. The evaluation of mental health risk factors revealed that shift work, occupational stress, and high payment/low return affect mental health. The somatization scores of different genotypes of rs6323 in the MAOA gene were statistically significant ( p < 0.05), suggesting that the somatization scores of different genotypes of rs6323 were different. According to the average rank, the TT genotype group had the highest score, followed by the GT genotype group, and the GG genotype group had the lowest score. The level of DNA methylation in the abnormal group was lower than that in the normal group ( p < 0.05). The results suggested that occupational mental health can be enhanced by improving shift work, reducing stress, and balancing effort and reward. This preliminary investigation suggests that methylation status can affect mental health, indicating that methylation level may be a predictor of mental health status.

Suggested Citation

  • Ting Jiang & Xue Li & Li Ning & Jiwen Liu, 2019. "Cross-Sectional Survey of Mental Health Risk Factors and Comparison of the Monoamine oxidase A Gene DNA Methylation Level in Different Mental Health Conditions among Oilfield Workers in Xinjiang, Chin," IJERPH, MDPI, vol. 17(1), pages 1-15, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2019:i:1:p:149-:d:301502
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    References listed on IDEAS

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    1. Sara Kangaspeska & Brenda Stride & Raphaël Métivier & Maria Polycarpou-Schwarz & David Ibberson & Richard Paul Carmouche & Vladimir Benes & Frank Gannon & George Reid, 2008. "Transient cyclical methylation of promoter DNA," Nature, Nature, vol. 452(7183), pages 112-115, March.
    2. Raphaël Métivier & Rozenn Gallais & Christophe Tiffoche & Christine Le Péron & Renata Z. Jurkowska & Richard P. Carmouche & David Ibberson & Peter Barath & Florence Demay & George Reid & Vladimir Bene, 2008. "Cyclical DNA methylation of a transcriptionally active promoter," Nature, Nature, vol. 452(7183), pages 45-50, March.
    3. Xiaoyan Gao & Hua Ge & Yu Jiang & Yulong Lian & Chen Zhang & Jiwen Liu, 2018. "Relationship between Job Stress and 5-HT2A Receptor Polymorphisms on Self-Reported Sleep Quality in Physicians in Urumqi (Xinjiang, China): A Cross-Sectional Study," IJERPH, MDPI, vol. 15(5), pages 1-15, May.
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