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The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants

Author

Listed:
  • Antoinesha L. Hollman

    (NIH/NIMHD RCMI Center for Environmental Heath, College of Science, Engineering, and Technology (CSET), Jackson State University, Jackson, MS 39217, USA
    These authors contributed equally to this work.)

  • Paul B. Tchounwou

    (NIH/NIMHD RCMI Center for Environmental Heath, College of Science, Engineering, and Technology (CSET), Jackson State University, Jackson, MS 39217, USA
    Department of Biology, CSET, Jackson State University, Jackson, MS 39217, USA)

  • Hung-Chung Huang

    (NIH/NIMHD RCMI Center for Environmental Heath, College of Science, Engineering, and Technology (CSET), Jackson State University, Jackson, MS 39217, USA
    Department of Biology, CSET, Jackson State University, Jackson, MS 39217, USA
    These authors contributed equally to this work.)

Abstract

Exposure to environmental hazards has been associated with diseases in humans. The identification of single nucleotide polymorphisms (SNPs) in human populations exposed to different environmental hazards, is vital for detecting the genetic risks of some important human diseases. Several studies in this field have been conducted on glutathione S-transferases (GSTs), a phase II detoxification superfamily, to investigate its role in the occurrence of diseases. Human GSTs consist of cytosolic and microsomal superfamilies that are further divided into subfamilies. Based on scientific search engines and a review of the literature, we have found a large amount of published articles on human GST super- and subfamilies that have greatly assisted in our efforts to examine their role in health and disease. Because of its polymorphic variations in relation to environmental hazards such as air pollutants, cigarette smoke, pesticides, heavy metals, carcinogens, pharmaceutical drugs, and xenobiotics, GST is considered as a significant biomarker. This review examines the studies on gene-environment interactions related to various diseases with respect to single nucleotide polymorphisms (SNPs) found in the GST superfamily. Overall, it can be concluded that interactions between GST genes and environmental factors play an important role in human diseases.

Suggested Citation

  • Antoinesha L. Hollman & Paul B. Tchounwou & Hung-Chung Huang, 2016. "The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants," IJERPH, MDPI, vol. 13(4), pages 1-14, March.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:4:p:379-:d:66682
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    References listed on IDEAS

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    1. Regina Grazuleviciene & Asta Danileviciute & Ruta Nadisauskiene & Jone Vencloviene, 2009. "Maternal Smoking,GSTM1 and GSTT1 Polymorphism and Susceptibility to Adverse Pregnancy Outcomes," IJERPH, MDPI, vol. 6(3), pages 1-16, March.
    2. Mohammad H. Rahbar & Maureen Samms-Vaughan & Jianzhong Ma & Jan Bressler & Katherine A. Loveland & Manouchehr Ardjomand-Hessabi & Aisha S. Dickerson & Megan L. Grove & Sydonnie Shakespeare-Pellington , 2014. "Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 11(8), pages 1-22, August.
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    Cited by:

    1. Ariane Mbemi & Sunali Khanna & Sylvianne Njiki & Clement G. Yedjou & Paul B. Tchounwou, 2020. "Impact of Gene–Environment Interactions on Cancer Development," IJERPH, MDPI, vol. 17(21), pages 1-15, November.

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