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Multi-omics signatures of the human early life exposome

Author

Listed:
  • Léa Maitre

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Mariona Bustamante

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)
    Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology)

  • Carles Hernández-Ferrer

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Denise Thiel

    (Imperial College London)

  • Chung-Ho E. Lau

    (Imperial College London
    Imperial College London)

  • Alexandros P. Siskos

    (Imperial College London)

  • Marta Vives-Usano

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)
    Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology)

  • Carlos Ruiz-Arenas

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Dolors Pelegrí-Sisó

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Oliver Robinson

    (Imperial College London)

  • Dan Mason

    (Bradford Teaching Hospitals NHS Foundation Trust)

  • John Wright

    (Bradford Teaching Hospitals NHS Foundation Trust)

  • Solène Cadiou

    (Inserm, CNRS, Université Grenoble Alpes)

  • Rémy Slama

    (Inserm, CNRS, Université Grenoble Alpes)

  • Barbara Heude

    (Inserm, Université de Paris)

  • Maribel Casas

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Jordi Sunyer

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)
    Hospital del Mar Medical Research Institute (IMIM))

  • Eleni Z. Papadopoulou

    (Norwegian Institute of Public Health)

  • Kristine B. Gutzkow

    (Norwegian Institute of Public Health)

  • Sandra Andrusaityte

    (Vytautas Magnus University)

  • Regina Grazuleviciene

    (Vytautas Magnus University)

  • Marina Vafeiadi

    (Faculty of Medicine, University of Crete)

  • Leda Chatzi

    (University of Southern California)

  • Amrit K. Sakhi

    (Norwegian Institute of Public Health)

  • Cathrine Thomsen

    (Norwegian Institute of Public Health)

  • Ibon Tamayo

    (CIMA-University of Navarra)

  • Mark Nieuwenhuijsen

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Jose Urquiza

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Eva Borràs

    (Universitat Pompeu Fabra (UPF)
    Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology)

  • Eduard Sabidó

    (Universitat Pompeu Fabra (UPF)
    Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology)

  • Inés Quintela

    (University of Santiago de Compostela, CIMUS)

  • Ángel Carracedo

    (University of Santiago de Compostela, CIMUS
    Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Servicio Gallego de Salud (SERGAS))

  • Xavier Estivill

    (Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology)

  • Muireann Coen

    (Imperial College London
    AstraZeneca)

  • Juan R. González

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Hector C. Keun

    (Imperial College London
    Imperial College London)

  • Martine Vrijheid

    (Institute for Global Health (ISGlobal)
    Universitat Pompeu Fabra (UPF)
    Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

Abstract

Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations ( https://helixomics.isglobal.org/ ) will serve to guide future investigation into the biological imprints of the early life exposome.

Suggested Citation

  • Léa Maitre & Mariona Bustamante & Carles Hernández-Ferrer & Denise Thiel & Chung-Ho E. Lau & Alexandros P. Siskos & Marta Vives-Usano & Carlos Ruiz-Arenas & Dolors Pelegrí-Sisó & Oliver Robinson & Dan, 2022. "Multi-omics signatures of the human early life exposome," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34422-2
    DOI: 10.1038/s41467-022-34422-2
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    References listed on IDEAS

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    Cited by:

    1. Silvia Rodrigues Jardim & Lucila Marieta Perrotta de Souza & Heitor Siffert Pereira de Souza, 2023. "The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?," IJERPH, MDPI, vol. 20(4), pages 1-23, February.

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