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Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican Children with and without Autism Spectrum Disorder

Author

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  • Mohammad H. Rahbar

    (Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA
    Division of Clinical and Translational Sciences, Department of Internal Medicine, Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, Texas 77030, USA)

  • Maureen Samms-Vaughan

    (Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica)

  • Jianzhong Ma

    (Division of Clinical and Translational Sciences, Department of Internal Medicine, Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Jan Bressler

    (Human Genetics Center, University of Texas School of Public Health at Houston, Houston, TX 77030, USA)

  • Katherine A. Loveland

    (Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Houston, TX 77054, USA)

  • Manouchehr Ardjomand-Hessabi

    (Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, Texas 77030, USA)

  • Aisha S. Dickerson

    (Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, Texas 77030, USA)

  • Megan L. Grove

    (Human Genetics Center, University of Texas School of Public Health at Houston, Houston, TX 77030, USA)

  • Sydonnie Shakespeare-Pellington

    (Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica)

  • Compton Beecher

    (Department of Basic Medical Sciences, The University of the West Indies, Mona Campus, Kingston 7, Jamaica)

  • Wayne McLaughlin

    (Department of Basic Medical Sciences, The University of the West Indies, Mona Campus, Kingston 7, Jamaica
    Caribbean Genetics (CARIGEN), The University of the West Indies, Mona Campus, Kingston 7, Jamaica)

  • Eric Boerwinkle

    (Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA
    Human Genetics Center, University of Texas School of Public Health at Houston, Houston, TX 77030, USA)

Abstract

Arsenic is a toxic metalloid with known adverse effects on human health. Glutathione-S-transferase (GST) genes, including GSTT1 , GSTP1 , and GSTM1 , play a major role in detoxification and metabolism of xenobiotics. We investigated the association between GST genotypes and whole blood arsenic concentrations (BASC) in Jamaican children with and without autism spectrum disorder (ASD). We used data from 100 ASD cases and their 1:1 age- and sex-matched typically developing (TD) controls (age 2–8 years) from Jamaica. Using log-transformed BASC as the dependent variable in a General Linear Model, we observed a significant interaction between GSTP1 and ASD case status while controlling for several confounding variables. However, for GSTT1 and GSTM1 we did not observe any significant associations with BASC. Our findings indicate that TD children who had the Ile/Ile or Ile/Val genotype for GSTP1 had a significantly higher geometric mean BASC than those with genotype Val/Val (3.67 µg/L vs. 2.69 µg/L, p < 0.01). Although, among the ASD cases, this difference was not statistically significant, the direction of the observed difference was consistent with that of the TD control children. These findings suggest a possible role of GSTP1 in the detoxification of arsenic.

Suggested Citation

  • Mohammad H. Rahbar & Maureen Samms-Vaughan & Jianzhong Ma & Jan Bressler & Katherine A. Loveland & Manouchehr Ardjomand-Hessabi & Aisha S. Dickerson & Megan L. Grove & Sydonnie Shakespeare-Pellington , 2014. "Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 11(8), pages 1-22, August.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:8:p:7874-7895:d:38910
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    References listed on IDEAS

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    1. Dario Siniscalco & Alessandra Cirillo & James Jeffrey Bradstreet & Nicola Antonucci, 2013. "Epigenetic Findings in Autism: New Perspectives for Therapy," IJERPH, MDPI, vol. 10(9), pages 1-13, September.
    2. Bingbing Wei & You Zhou & Zhuoqun Xu & Jun Ruan & Huan Cheng & Ming Zhu & Qiang Hu & Ke Jin & Zhiqiang Yan & Deqi Zhou & Feng Xuan & Hongyi Zhou & Zhirong Wang & Xing Huang & Qiang Wang, 2013. "GSTP1 Ile105Val Polymorphism and Prostate Cancer Risk: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-6, August.
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    Cited by:

    1. Mohammad H. Rahbar & Maureen Samms-Vaughan & Sepideh Saroukhani & Jan Bressler & Manouchehr Hessabi & Megan L. Grove & Sydonnie Shakspeare-Pellington & Katherine A. Loveland & Compton Beecher & Wayne , 2021. "Associations of Metabolic Genes ( GSTT1 , GSTP1 , GSTM1 ) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 18(4), pages 1-20, February.
    2. Manouchehr Hessabi & Mohammad H. Rahbar & Iuliana Dobrescu & MacKinsey A. Bach & Liana Kobylinska & Jan Bressler & Megan L. Grove & Katherine A. Loveland & Ilinca Mihailescu & Maria Cristina Nedelcu &, 2019. "Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in Blood of Romanian Children Suspected of Having Autism Spectrum Disorder," IJERPH, MDPI, vol. 16(13), pages 1-20, June.
    3. Mohammad H. Rahbar & Maureen Samms-Vaughan & Meagan R. Pitcher & Jan Bressler & Manouchehr Hessabi & Katherine A. Loveland & MacKinsey A. Christian & Megan L. Grove & Sydonnie Shakespeare-Pellington &, 2016. "Role of Metabolic Genes in Blood Aluminum Concentrations of Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 13(11), pages 1-19, November.
    4. Mohammad H. Rahbar & Maureen Samms-Vaughan & Yuansong Zhao & Sepideh Saroukhani & Sheikh F. Zaman & Jan Bressler & Manouchehr Hessabi & Megan L. Grove & Sydonnie Shakspeare-Pellington & Katherine A. L, 2022. "Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Child," IJERPH, MDPI, vol. 19(1), pages 1-19, January.
    5. Mohammad H. Rahbar & Shahnaz H. Ibrahim & Syed Iqbal Azam & Manouchehr Hessabi & Fatima Karim & Sori Kim & Jing Zhang & Nasreen Gulzar Ali & Katherine A. Loveland, 2021. "Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in the Blood of Pakistani Children with and without Autism Spectrum Disorder and Their Associated Factors," IJERPH, MDPI, vol. 18(16), pages 1-18, August.
    6. Antoinesha L. Hollman & Paul B. Tchounwou & Hung-Chung Huang, 2016. "The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants," IJERPH, MDPI, vol. 13(4), pages 1-14, March.
    7. Mohammad H. Rahbar & Maureen Samms-Vaughan & Aisha S. Dickerson & Katherine A. Loveland & Manouchehr Ardjomand-Hessabi & Jan Bressler & Sydonnie Shakespeare-Pellington & Megan L. Grove & Deborah A. Pe, 2014. "Blood Lead Concentrations in Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 12(1), pages 1-23, December.
    8. Lingqian Xu & Debapriya Mondal & David A. Polya, 2020. "Positive Association of Cardiovascular Disease (CVD) with Chronic Exposure to Drinking Water Arsenic (As) at Concentrations below the WHO Provisional Guideline Value: A Systematic Review and Meta-anal," IJERPH, MDPI, vol. 17(7), pages 1-24, April.

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