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Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica

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  • Mohammad H. Rahbar

    (Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Division of Clinical and Translational Sciences, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Maureen Samms-Vaughan

    (Department of Child & Adolescent Health, Mona Campus, The University of the West Indies (UWI), Kingston 7, Jamaica)

  • Yuansong Zhao

    (Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Department of Biostatistics & Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Sepideh Saroukhani

    (Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Sheikh F. Zaman

    (Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Jan Bressler

    (Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Manouchehr Hessabi

    (Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Megan L. Grove

    (Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Sydonnie Shakspeare-Pellington

    (Department of Child & Adolescent Health, Mona Campus, The University of the West Indies (UWI), Kingston 7, Jamaica)

  • Katherine A. Loveland

    (“Louis A Faillace, MD”, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA)

Abstract

Arsenic (As) is a metalloid that has been classified as a xenobiotic with toxic effects on human beings, especially on children. Since the soil in Jamaica contains As, dietary intake is considered the main source of As exposure in Jamaicans. In addition, glutathione S-transferase (GST) genes, including GSTT1 , GSTP1 , and GSTM1, play an important role in the metabolism of xenobiotics including As in humans. Using data from 375 typically developing children (2–8 years) in Jamaica, we investigated the environmental and sociodemographic factors, as well as their possible interactions with the children’s genotype for GST genes in relation to having a detectable level of blood As concentration (i.e., >1.3 μg/L). Using multivariable logistic regression, we have identified environmental factors significantly associated with blood As concentrations that include a child’s age, parental education levels, and the consumption of saltwater fish, cabbage, broad beans, and avocado (all p < 0.01). Based on the multivariable analysis including gene x environment interactions, we found that among children with the Ile/Ile genotype for GSTP1 Ile105Val, children who consumed avocado had higher odds of having a detectable blood As concentration compared to children who did not eat avocado.

Suggested Citation

  • Mohammad H. Rahbar & Maureen Samms-Vaughan & Yuansong Zhao & Sepideh Saroukhani & Sheikh F. Zaman & Jan Bressler & Manouchehr Hessabi & Megan L. Grove & Sydonnie Shakspeare-Pellington & Katherine A. L, 2022. "Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Child," IJERPH, MDPI, vol. 19(1), pages 1-19, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:1:p:466-:d:716113
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    References listed on IDEAS

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    1. Argos, M. & Parvez, F. & Chen, Y. & Hussain, A.Z.M.I. & Momotaj, H. & Howe, G.R. & Graziano, J.H. & Ahsan, H., 2007. "Socioeconomic status and risk for arsenic-related skin lesions in Bangladesh," American Journal of Public Health, American Public Health Association, vol. 97(5), pages 825-831.
    2. Debbie S Thompson & Novie Younger-Coleman & Parris Lyew-Ayee & Lisa-Gaye Greene & Michael S Boyne & Terrence E Forrester, 2017. "Socioeconomic factors associated with severe acute malnutrition in Jamaica," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-15, March.
    3. Laila N. Islam & AHM Nurun Nabi & M Mahfuzur Rahman & Monsur A. Khan & Azizul I. Kazi, 2004. "Association of Clinical Complications with Nutritional Status and the Prevalence of Leukopenia among Arsenic Patients in Bangladesh," IJERPH, MDPI, vol. 1(2), pages 1-9, September.
    4. Mohammad H. Rahbar & Maureen Samms-Vaughan & Jianzhong Ma & Jan Bressler & Katherine A. Loveland & Manouchehr Ardjomand-Hessabi & Aisha S. Dickerson & Megan L. Grove & Sydonnie Shakespeare-Pellington , 2014. "Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 11(8), pages 1-22, August.
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