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Impact of Gene–Environment Interactions on Cancer Development

Author

Listed:
  • Ariane Mbemi

    (NIH/NIMHD RCMI-Center for Health Disparities Research, Jackson State University, 1400 Lynch Street, Box 18750, Jackson, MS 39217, USA
    Department of Biology, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, Box 18540, Jackson, MS 39217, USA)

  • Sunali Khanna

    (Department of Oral Medicine and Radiology, Nair Hospital Dental College, Municipal Corporation of Greater Mumbai, Mumbai 400 008, India)

  • Sylvianne Njiki

    (NIH/NIMHD RCMI-Center for Health Disparities Research, Jackson State University, 1400 Lynch Street, Box 18750, Jackson, MS 39217, USA
    Department of Biology, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, Box 18540, Jackson, MS 39217, USA)

  • Clement G. Yedjou

    (Department of Biological Sciences, College of Science and Technology, Florida Agricultural and Mechanical University, 1610 S. Martin Luther King Blvd., Tallahassee, FL 32307, USA)

  • Paul B. Tchounwou

    (NIH/NIMHD RCMI-Center for Health Disparities Research, Jackson State University, 1400 Lynch Street, Box 18750, Jackson, MS 39217, USA
    Department of Biology, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, Box 18540, Jackson, MS 39217, USA)

Abstract

Several epidemiological and experimental studies have demonstrated that many human diseases are not only caused by specific genetic and environmental factors but also by gene–environment interactions. Although it has been widely reported that genetic polymorphisms play a critical role in human susceptibility to cancer and other chronic disease conditions, many single nucleotide polymorphisms (SNPs) are caused by somatic mutations resulting from human exposure to environmental stressors. Scientific evidence suggests that the etiology of many chronic illnesses is caused by the joint effect between genetics and the environment. Research has also pointed out that the interactions of environmental factors with specific allelic variants highly modulate the susceptibility to diseases. Hence, many scientific discoveries on gene–environment interactions have elucidated the impact of their combined effect on the incidence and/or prevalence rate of human diseases. In this review, we provide an overview of the nature of gene–environment interactions, and discuss their role in human cancers, with special emphases on lung, colorectal, bladder, breast, ovarian, and prostate cancers.

Suggested Citation

  • Ariane Mbemi & Sunali Khanna & Sylvianne Njiki & Clement G. Yedjou & Paul B. Tchounwou, 2020. "Impact of Gene–Environment Interactions on Cancer Development," IJERPH, MDPI, vol. 17(21), pages 1-15, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:8089-:d:439195
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    References listed on IDEAS

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    1. James Y. Dai & Charles Kooperberg & Michael Leblanc & Ross L. Prentice, 2012. "Two-stage testing procedures with independent filtering for genome-wide gene-environment interaction," Biometrika, Biometrika Trust, vol. 99(4), pages 929-944.
    2. Antoinesha L. Hollman & Paul B. Tchounwou & Hung-Chung Huang, 2016. "The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants," IJERPH, MDPI, vol. 13(4), pages 1-14, March.
    3. Marilyn C Cornelis & Keri L Monda & Kai Yu & Nina Paynter & Elizabeth M Azzato & Siiri N Bennett & Sonja I Berndt & Eric Boerwinkle & Stephen Chanock & Nilanjan Chatterjee & David Couper & Gary Curhan, 2011. "Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption," PLOS Genetics, Public Library of Science, vol. 7(4), pages 1-9, April.
    4. Rosemarie G. Ramos & Kenneth Olden, 2008. "Gene-Environment Interactions in the Development of Complex Disease Phenotypes," IJERPH, MDPI, vol. 5(1), pages 1-8, March.
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